Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

Table 3 Associations between genotypes of acrylamide-metabolising enzymes and birth outcomes

SNP^a	Estimated change in birth outcome (95% CI)
SNP^a	Birth weight (gram)	p	Birth length (cm)	p	Birth head circumference (CM)	p
rs915906	24.5 (−36.9, 86.0)	0.43	−0.17 (− 0.44, 0.10)	0.22	− 0.04 (− 0.26, 0.19)	0.74
rs2480258	19.1 (−40.3, 78.5)	0.53	− 0.19 (− 0.45, 0.07)	0.16	− 0.02 (− 0.24, 0.20)	0.85
rs11101888	18.8 (− 56.0, 93.7)	0.62	0.05 (− 0.28, 0.38)	0.77	0.19 (− 0.07, 0.44)	0.15
rs1051740	−17.6 (−76.3, 41.1)	0.56	0.05 (− 0.21, 0.31)	0.70	− 0.02 (− 0.23, 0.20)	0.89
rs1695	2.0 (−56.2, 60.2)	0.95	−0.02 (− 0.28, 0.23)	0.86	0.04 (− 0.17, 0.25)	0.71
rs1138272	−7.3 (−86.6, 72.1)	0.86	−0.09 (− 0.44, 0.26)	0.60	− 0.03 (− 0.32, 0.27)	0.86

Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery
^amodeled is the regression coefficient of 1 or 2 variant alleles of the SNP compared to the homozygous wildtype

ISSN: 1476-069X