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Table 4 Associations between acrylamide and glycidamide hemoglobin adducts in cord blood and birth outcomes

From: Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

   Unadjusted regression coefficient (95% CI) Multivariable-adjusted regression coefficient (95% CI)
Continuous exposure variable (per 10 pmol/g hemoglobin) Quartiles of exposure Continuous exposure variable (per 10 pmol/g hemoglobin) Quartiles of exposure
n Regression coefficient (95% CI)a p Q1
REF
Q2 Q3 Q4 p for trend Regression coefficient (95% CI)a p Q1
REF
Q2 Q3 Q4 p for trend
Acrylamide hemoglobin adducts among all participants
 Weight, g 443 −59
(−88, −31)
< 0.001 1 −74
(−188, 41)
−98
(− 212, 17)
− 149
(− 263, 34)
0.08 −40
(− 71, −9)
0.01 1 −30
(− 127, 67)
−102
(−200, − 5)
−101
(−208, 7)
0.12
 Length, cm 442 −0.24
(−0.37, − 0.11)
< 0.001 1 − 0.22
(− 0.73, 0.30)
0.17
(− 0.35, 0.68)
−0.35
(− 0.86, 0.16)
0.19 −0.17
(− 0.31, − 0.03)
0.02 1 −0.03
(− 0.48, 0.41)
0.15
(−-0.29, 0.60)
−0.13
(− 0.62, 0.36)
0.69
 Head circumference, cm 432 −0.15
(− 0.24, − 0.05)
0.003 1 −0.33
(− 0.72, 0.06)
−0.51
(− 0.90, − 0.12)
−0.54
(− 0.92, − 0.15)
0.03 −0.13
(− 0.24, − 0.01)
0.03 1 −0.16
(− 0.52, 0.19)
−0.45
(− 0.81, − 0.09)
−0.41
(− 0.80, − 0.01)
0.06
Acrylamide hemoglobin adducts among neonates from non-smoking mothers
 Weight, g 380 −58
(−113, − 4)
0.04 1 −67
(− 181, 47)
− 88
(− 202, 25)
− 30
(− 170, 110)
0.45 −52
(− 98, − 5)
0.03 1 −26
(− 123, 72)
− 101
(− 200, − 2)
− 77
(− 197, 43)
0.19
 Length, cm 379 −0.17
(− 0.42, 0.08)
0.18 1 − 0.21
(− 0.73, 0.31)
0.19
(− 0.33, 0.70)
0.27
(− 0.37, 0.90)
0.35 −0.18
(− 0.40, 0.04)
0.10 1 − 0.04
(− 0.49, 0.41)
0.15
(− 0.31, 0.60)
−0.00
(− 0.56, 0.55)
0.86
 Head circumference, cm 369 −0.23
(− 0.42, − 0.04)
0.02 1 −0.32
(− 0.72, 0.07)
−0.48
(− 0.87, − 0.08)
−0.36
(− 0.85, 0.13)
0.12 −0.22
(− 0.40, − 0.05)
0.01 1 −0.16
(− 0.52, 0.21)
−0.42
(− 0.80, − 0.05)
−0.48
(− 0.94, − 0.03)
0.07
Glycidamide hemoglobin adducts among all participants
 Weight, g 393 −80
(− 117, − 44)
< 0.001 1 − 161
(− 282, − 40)
− 175
(− 297, − 54)
−267
(− 387, − 146)
< 0.001 − 53
(− 90, − 16)
0.005 1 − 144
(− 246, − 43)
− 154
(− 258, − 49)
−222
(− 337, − 108)
0.001
 Length, cm 392 − 0.35
(− 0.52, − 0.19)
< 0.001 1 −0.55
(− 1.09, − 0.01)
− 0.59
(− 1.13, − 0.05)
−1.10
(− 1.64, − 0.56)
0.001 − 0.24
(− 0.41, − 0.08)
  1 −0.46
(− 0.93, 0.01)
−0.48
(− 0.96, − 0.00)
−0.85
(− 1.38, − 0.33)
0.02
 Head circumference, cm 382 − 0.17
(− 0.30, − 0.05)
0.007 1 − 0.69
(− 1.10, − 0.27)
− 0.74
(− 1.16, − 0.33)
− 0.74
(− 1.15, − 0.32)
< 0.001 − 0.11
(− 0.25, 0.03)
  1 − 0.61
(− 0.99, − 0.23)
− 0.61
(− 1.00, − 0.21)
− 0.55
(− 0.98, − 0.11)
0.01
Glycidamide hemoglobin adducts among neonates from non-smoking mothers
 Weight, g 331 −121
(− 193, − 50)
< 0.001 1 − 164
(− 285, − 43)
− 176
(− 296, − 50)
−176
(− 327, − 25)
0.01 − 104
(− 165, − 43)
0.001 1 −152
(− 255, − 50)
−161
(− 268, − 54)
−225
(− 355, − 95)
0.002
 Length, cm 330 − 0.48
(− 0.80, − 0.15)
0.004 1 −0.56
(− 1.11, − 0.01)
−0.61
(− 1.17, − 0.05)
−0.64
(− 1.33, 0.05)
0.10 − 0.42
(− 0.70, − 0.13)
0.004 1 −0.50
(− 0.98, − 0.02)
− 0.56
(− 1.06, − 0.06)
−0.81
(− 1.42, − 0.21)
0.04
 Head circumference, cm 320 − 0.36
(− 0.62, − 0.11)
0.005 1 −0.69
(− 1.11, − 0.27)
−0.72
(− 1.15, − 0.29)
−0.55
(− 1.09, − 0.02)
0.003 − 0.31
(− 0.55, − 0.07)
0.01 1 −0.61
(− 1.01, − 0.22)
−0.61
(− 1.02, − 0.19)
−0.63
(− 1.14, − 0.13)
0.007
  1. Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery
  2. aRegression coefficient (95% confidence interval) per 10 pmol/g hemoglobin increase in AA-Hb and GA-Hb adducts