Table 4 Associations between acrylamide and glycidamide hemoglobin adducts in cord blood and birth outcomes
| Â | Â | Unadjusted regression coefficient (95% CI) | Multivariable-adjusted regression coefficient (95% CI) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Continuous exposure variable (per 10 pmol/g hemoglobin) | Quartiles of exposure | Continuous exposure variable (per 10 pmol/g hemoglobin) | Quartiles of exposure | ||||||||||||
n | Regression coefficient (95% CI)a | p | Q1 REF | Q2 | Q3 | Q4 | p for trend | Regression coefficient (95% CI)a | p | Q1 REF | Q2 | Q3 | Q4 | p for trend | |
Acrylamide hemoglobin adducts among all participants | |||||||||||||||
 Weight, g | 443 | −59 (−88, −31) | < 0.001 | 1 | −74 (−188, 41) | −98 (− 212, 17) | − 149 (− 263, 34) | 0.08 | −40 (− 71, −9) | 0.01 | 1 | −30 (− 127, 67) | −102 (−200, − 5) | −101 (−208, 7) | 0.12 |
 Length, cm | 442 | −0.24 (−0.37, − 0.11) | < 0.001 | 1 | − 0.22 (− 0.73, 0.30) | 0.17 (− 0.35, 0.68) | −0.35 (− 0.86, 0.16) | 0.19 | −0.17 (− 0.31, − 0.03) | 0.02 | 1 | −0.03 (− 0.48, 0.41) | 0.15 (−-0.29, 0.60) | −0.13 (− 0.62, 0.36) | 0.69 |
 Head circumference, cm | 432 | −0.15 (− 0.24, − 0.05) | 0.003 | 1 | −0.33 (− 0.72, 0.06) | −0.51 (− 0.90, − 0.12) | −0.54 (− 0.92, − 0.15) | 0.03 | −0.13 (− 0.24, − 0.01) | 0.03 | 1 | −0.16 (− 0.52, 0.19) | −0.45 (− 0.81, − 0.09) | −0.41 (− 0.80, − 0.01) | 0.06 |
Acrylamide hemoglobin adducts among neonates from non-smoking mothers | |||||||||||||||
 Weight, g | 380 | −58 (−113, − 4) | 0.04 | 1 | −67 (− 181, 47) | − 88 (− 202, 25) | − 30 (− 170, 110) | 0.45 | −52 (− 98, − 5) | 0.03 | 1 | −26 (− 123, 72) | − 101 (− 200, − 2) | − 77 (− 197, 43) | 0.19 |
 Length, cm | 379 | −0.17 (− 0.42, 0.08) | 0.18 | 1 | − 0.21 (− 0.73, 0.31) | 0.19 (− 0.33, 0.70) | 0.27 (− 0.37, 0.90) | 0.35 | −0.18 (− 0.40, 0.04) | 0.10 | 1 | − 0.04 (− 0.49, 0.41) | 0.15 (− 0.31, 0.60) | −0.00 (− 0.56, 0.55) | 0.86 |
 Head circumference, cm | 369 | −0.23 (− 0.42, − 0.04) | 0.02 | 1 | −0.32 (− 0.72, 0.07) | −0.48 (− 0.87, − 0.08) | −0.36 (− 0.85, 0.13) | 0.12 | −0.22 (− 0.40, − 0.05) | 0.01 | 1 | −0.16 (− 0.52, 0.21) | −0.42 (− 0.80, − 0.05) | −0.48 (− 0.94, − 0.03) | 0.07 |
Glycidamide hemoglobin adducts among all participants | |||||||||||||||
 Weight, g | 393 | −80 (− 117, − 44) | < 0.001 | 1 | − 161 (− 282, − 40) | − 175 (− 297, − 54) | −267 (− 387, − 146) | < 0.001 | − 53 (− 90, − 16) | 0.005 | 1 | − 144 (− 246, − 43) | − 154 (− 258, − 49) | −222 (− 337, − 108) | 0.001 |
 Length, cm | 392 | − 0.35 (− 0.52, − 0.19) | < 0.001 | 1 | −0.55 (− 1.09, − 0.01) | − 0.59 (− 1.13, − 0.05) | −1.10 (− 1.64, − 0.56) | 0.001 | − 0.24 (− 0.41, − 0.08) |  | 1 | −0.46 (− 0.93, 0.01) | −0.48 (− 0.96, − 0.00) | −0.85 (− 1.38, − 0.33) | 0.02 |
 Head circumference, cm | 382 | − 0.17 (− 0.30, − 0.05) | 0.007 | 1 | − 0.69 (− 1.10, − 0.27) | − 0.74 (− 1.16, − 0.33) | − 0.74 (− 1.15, − 0.32) | < 0.001 | − 0.11 (− 0.25, 0.03) |  | 1 | − 0.61 (− 0.99, − 0.23) | − 0.61 (− 1.00, − 0.21) | − 0.55 (− 0.98, − 0.11) | 0.01 |
Glycidamide hemoglobin adducts among neonates from non-smoking mothers | |||||||||||||||
 Weight, g | 331 | −121 (− 193, − 50) | < 0.001 | 1 | − 164 (− 285, − 43) | − 176 (− 296, − 50) | −176 (− 327, − 25) | 0.01 | − 104 (− 165, − 43) | 0.001 | 1 | −152 (− 255, − 50) | −161 (− 268, − 54) | −225 (− 355, − 95) | 0.002 |
 Length, cm | 330 | − 0.48 (− 0.80, − 0.15) | 0.004 | 1 | −0.56 (− 1.11, − 0.01) | −0.61 (− 1.17, − 0.05) | −0.64 (− 1.33, 0.05) | 0.10 | − 0.42 (− 0.70, − 0.13) | 0.004 | 1 | −0.50 (− 0.98, − 0.02) | − 0.56 (− 1.06, − 0.06) | −0.81 (− 1.42, − 0.21) | 0.04 |
 Head circumference, cm | 320 | − 0.36 (− 0.62, − 0.11) | 0.005 | 1 | −0.69 (− 1.11, − 0.27) | −0.72 (− 1.15, − 0.29) | −0.55 (− 1.09, − 0.02) | 0.003 | − 0.31 (− 0.55, − 0.07) | 0.01 | 1 | −0.61 (− 1.01, − 0.22) | −0.61 (− 1.02, − 0.19) | −0.63 (− 1.14, − 0.13) | 0.007 |