Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

Hogervorst, Janneke; Vesper, Hubert W.; Madhloum, Narjes; Gyselaers, Wilfried; Nawrot, Tim

doi:10.1186/s12940-021-00715-0

Environmental Health

Table 5 Interactions between genetic variants and cord blood acrylamide adduct levels on birth outcomes

From: Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

	All				Non-smoking mothers
	n	Acrylamide regression coefficient	95% CI	p for interaction	n	Acrylamide regression coefficient	95% CI	p for interaction
*Birth weight*
CYP2E1 rs915906 = 0^a	196	−62.1	− 130.3, 6.1	0.80	169	−37.0	− 145.0, 71.0	0.87
CYP2E1 rs915906 = 1^a	83	−54.9	− 143.4, 33.6		70	12.3	−167.4, 192.0
CYP2E1 rs2480258 = 0	174	−74.5	− 146.3, − 2.6	0.64	148	−66.9	− 187.8, 54.4	0.59
CYP2E1 rs2480258 = 1	107	−45.1	− 121.9, 31.8		92	7.8	− 135.3, 150.9
CYP2E1 rs11101888 = 0	234	−77.8	−136.4, − 19.3	0.17	199	−57.9	−164.2, 48.4	0.34
CYP2E1 rs11101888 = 1	47	10.2	−154.4, 174.7		41	35.3	−141.1, 211.7
EPHX1 rs1051740 = 0	157	−55.6	−141.8, 30.5	0.15	137	−83.1	−249.6, 83.3	0.49
EPHX1 rs1051740 = 1	131	−43.9	−112.6, 24.8		109	7.8	−103.3, 118.9
GSTP1 rs1695 = 0	129	−51.4	120.4, 17.6	0.85	105	−34.4	−146.8, 78.0	0.82
GSTP1 rs1695 = 1	166	−68.3	− 162.2, 5.6		144	−42.4	−196.2, 111.4
GSTP1 rs1138272 = 0	237	−51.7	−109.2, 5.8	0.46	202	−0.1	−95.9, 95.7	0.28
GSTP1 rs1138272 = 1	52	− 121.5	− 347.0, 104.1		43	− 148.4	− 415.6, 118.8
Sum of 3 CYP2E1 SNPs = 0	163	− 78.0	− 149.9, −6.0	0.38	138	−77.8	− 200.5, 45.0	0.35
Sum of 3 CYP2E1 SNPs ≥1	103	−36.3	−118.8, 46.2		88	44.4	−103.2, 191.9
Sum of 2 GSTP1 SNPs = 0	117	−42.5	−114.5, 29.5	0.59	99	−24.2	−137.9, 89.5	0.84
Sum of 2 GSTP1 SNPs ≥1	166	−85.4	− 168.9, −1.9		145	−63.7	−212.1, 84.7
*Birth length*
CYP2E1 rs915906 = 0	196	− 0.21	− 0.50, 0.09	0.69	169	−0.09	− 0.56, 0.39	0.42
CYP2E1 rs915906 = 1	83	−0.19	− 0.61, 0.24		70	0.21	−0.65, 1.06
CYP2E1 rs2480258 = 0	174	−0.22	−0.52, 0.09	0.76	148	−0.14	−0.66, 0.37	0.52
CYP2E1 rs2480258 = 1	107	− 0.19	− 0.56, 0.17		92	0.07	−0.63, 0.78
CYP2E1 rs11101888 = 0	234	− 0.22	− 0.48, 0.04	0.32	199	− 0.02	−0.49, 0.46	0.97
CYP2E1 rs11101888 = 1	47	− 0.23	−0.91, 0.46		41	−0.12	−0.92, 0.67
EPHX1 rs1051740 = 0	157	− 0.23	− 0.61, 0.16	0.50	138	0.28	−0.45, 1.01	0.85
EPHX1 rs1051740 = 1	131	−0.11	− 0.43, 0.20		109	0.02	−0.50, 0.54
GSTP1 rs1695 = 0	129	−0.27	−0.58, 0.04	0.33	105	−0.28	−0.80, 0.24	0.19
GSTP1 rs1695 = 1	166	−0.04	−0.40, 0.32		144	0.55	− 0.11, 1.21
GSTP1 rs1138272 = 0	237	−0.11	−0.35, 0.14	0.46	202	0.11	−0.31, 0.53	0.93
GSTP1 rs1138272 = 1	52	−0.81	−1.89, 0.27		43	−0.28	−1.75, 1.18
Sum of 3 CYP2E1 SNPs = 0	167	−0.24	−0.54, 0.07	0.64	138	−0.16	−0.68, 0.36	0.55
Sum of 3 CYP2E1 SNPs ≥1	105	−0.21	−0.60, 0.17		88	−0.00	−0.71, 0.70
Sum of 2 GSTP1 SNPs = 0	120	−0.22	−0.55, 0.12	0.59	99	−0.24	−0.77, 0.29	0.33
Sum of 2 GSTP1 SNPs ≥1	167	−0.10	−0.47, 0.27		145	0.44	−0.21, 1.09
*Birth head circumference*
CYP2E1 rs915906 = 0	192	−0.10	−0.38, 0.17	0.42	165	−0.38	−0.84, 0.07	0.56
CYP2E1 rs915906 = 1	81	−0.19	−0.47, 0.08		68	−0.14	−0.71, 0.43
CYP2E1 rs2480258 = 0	171	−0.15	−0.44, 0.14	0.19	145	−0.53	−1.03, − 0.03	0.22
CYP2E1 rs2480258 = 1	104	−0.16	− 0.40, 0.08		89	−0.07	− 0.54, 0.40
CYP2E1 rs11101888 = 0	229	−0.22	− 0.44, 0.01	0.36	194	−0.46	− 0.88, − 0.04	0.31
CYP2E1 rs11101888 = 1	47	−0.21	− 0.71, 0.29		40	−0.13	− 0.72, 0.46
EPHX1 rs1051740 = 0	157	−0.23	− 0.51, 0.06	0.54	137	−0.39	− 0.92, 0.15	0.91
EPHX1 rs1051740 = 1	125	−0.09	− 0.40, 0.22		103	−0.33	− 0.86, 0.20
GSTP1 rs1695 = 0	121	−0.13	− 0.43, 0.17	0.31	101	−0.29	− 0.83, 0.25	0.84
GSTP1 rs1695 = 1	163	−0.23	− 0.50, 0.05		142	−0.46	− 0.96, 0.04
GSTP1 rs1138272 = 0	228	−0.16	− 0.38, 0.06	0.39	197	−0.26	− 0.64, 0.13	0.34
GSTP1 rs1138272 = 1	51	−0.44	−1.20, 0.33		42	−0.87	−1.81, 0.07
Sum of 3 CYP2E1 SNPs = 0	160	−0.16	−0.46, 0.14	0.24	135	−0.58	−1.01, − 0.06	0.15
Sum of 3 CYP2E1 SNPs ≥1	100	−0.16	−0.41, 0.10		85	0.02	−0.46, 0.51
Sum of 2 GSTP1 SNPs = 0	113	−0.07	−0.40, 0.26	0.70	95	−0.27	−0.82, 0.29	0.59
Sum of 2 GSTP1 SNPs ≥1	164	−0.27	−0.54, 0.00		143	−0.49	−0.96, − 0.01

Adjusted for: maternal pre-pregnancy BMI (kg/m²), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery
^a0 = homozygous wildtype, 1 = 1 or 2 variant alleles for SNPs

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ISSN: 1476-069X

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