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Table 5 Interactions between genetic variants and cord blood acrylamide adduct levels on birth outcomes

From: Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

  All Non-smoking mothers
n Acrylamide regression coefficient 95% CI p for interaction n Acrylamide regression coefficient 95% CI p for interaction
Birth weight
CYP2E1 rs915906 = 0a 196 −62.1 − 130.3, 6.1 0.80 169 −37.0 − 145.0, 71.0 0.87
CYP2E1 rs915906 = 1a 83 −54.9 − 143.4, 33.6   70 12.3 −167.4, 192.0  
CYP2E1 rs2480258 = 0 174 −74.5 − 146.3, − 2.6 0.64 148 −66.9 − 187.8, 54.4 0.59
CYP2E1 rs2480258 = 1 107 −45.1 − 121.9, 31.8   92 7.8 − 135.3, 150.9  
CYP2E1 rs11101888 = 0 234 −77.8 −136.4, − 19.3 0.17 199 −57.9 −164.2, 48.4 0.34
CYP2E1 rs11101888 = 1 47 10.2 −154.4, 174.7   41 35.3 −141.1, 211.7  
EPHX1 rs1051740 = 0 157 −55.6 −141.8, 30.5 0.15 137 −83.1 −249.6, 83.3 0.49
EPHX1 rs1051740 = 1 131 −43.9 −112.6, 24.8   109 7.8 −103.3, 118.9  
GSTP1 rs1695 = 0 129 −51.4 120.4, 17.6 0.85 105 −34.4 −146.8, 78.0 0.82
GSTP1 rs1695 = 1 166 −68.3 − 162.2, 5.6   144 −42.4 −196.2, 111.4  
GSTP1 rs1138272 = 0 237 −51.7 −109.2, 5.8 0.46 202 −0.1 −95.9, 95.7 0.28
GSTP1 rs1138272 = 1 52 − 121.5 − 347.0, 104.1   43 − 148.4 − 415.6, 118.8  
 Sum of 3 CYP2E1 SNPs = 0 163 − 78.0 − 149.9, −6.0 0.38 138 −77.8 − 200.5, 45.0 0.35
 Sum of 3 CYP2E1 SNPs ≥1 103 −36.3 −118.8, 46.2   88 44.4 −103.2, 191.9  
 Sum of 2 GSTP1 SNPs = 0 117 −42.5 −114.5, 29.5 0.59 99 −24.2 −137.9, 89.5 0.84
 Sum of 2 GSTP1 SNPs ≥1 166 −85.4 − 168.9, −1.9   145 −63.7 −212.1, 84.7  
Birth length
 CYP2E1 rs915906 = 0 196 − 0.21 − 0.50, 0.09 0.69 169 −0.09 − 0.56, 0.39 0.42
 CYP2E1 rs915906 = 1 83 −0.19 − 0.61, 0.24   70 0.21 −0.65, 1.06  
 CYP2E1 rs2480258 = 0 174 −0.22 −0.52, 0.09 0.76 148 −0.14 −0.66, 0.37 0.52
 CYP2E1 rs2480258 = 1 107 − 0.19 − 0.56, 0.17   92 0.07 −0.63, 0.78  
 CYP2E1 rs11101888 = 0 234 − 0.22 − 0.48, 0.04 0.32 199 − 0.02 −0.49, 0.46 0.97
 CYP2E1 rs11101888 = 1 47 − 0.23 −0.91, 0.46   41 −0.12 −0.92, 0.67  
 EPHX1 rs1051740 = 0 157 − 0.23 − 0.61, 0.16 0.50 138 0.28 −0.45, 1.01 0.85
 EPHX1 rs1051740 = 1 131 −0.11 − 0.43, 0.20   109 0.02 −0.50, 0.54  
 GSTP1 rs1695 = 0 129 −0.27 −0.58, 0.04 0.33 105 −0.28 −0.80, 0.24 0.19
 GSTP1 rs1695 = 1 166 −0.04 −0.40, 0.32   144 0.55 − 0.11, 1.21  
 GSTP1 rs1138272 = 0 237 −0.11 −0.35, 0.14 0.46 202 0.11 −0.31, 0.53 0.93
 GSTP1 rs1138272 = 1 52 −0.81 −1.89, 0.27   43 −0.28 −1.75, 1.18  
 Sum of 3 CYP2E1 SNPs = 0 167 −0.24 −0.54, 0.07 0.64 138 −0.16 −0.68, 0.36 0.55
 Sum of 3 CYP2E1 SNPs ≥1 105 −0.21 −0.60, 0.17   88 −0.00 −0.71, 0.70  
 Sum of 2 GSTP1 SNPs = 0 120 −0.22 −0.55, 0.12 0.59 99 −0.24 −0.77, 0.29 0.33
 Sum of 2 GSTP1 SNPs ≥1 167 −0.10 −0.47, 0.27   145 0.44 −0.21, 1.09  
Birth head circumference
 CYP2E1 rs915906 = 0 192 −0.10 −0.38, 0.17 0.42 165 −0.38 −0.84, 0.07 0.56
 CYP2E1 rs915906 = 1 81 −0.19 −0.47, 0.08   68 −0.14 −0.71, 0.43  
 CYP2E1 rs2480258 = 0 171 −0.15 −0.44, 0.14 0.19 145 −0.53 −1.03, − 0.03 0.22
 CYP2E1 rs2480258 = 1 104 −0.16 − 0.40, 0.08   89 −0.07 − 0.54, 0.40  
 CYP2E1 rs11101888 = 0 229 −0.22 − 0.44, 0.01 0.36 194 −0.46 − 0.88, − 0.04 0.31
 CYP2E1 rs11101888 = 1 47 −0.21 − 0.71, 0.29   40 −0.13 − 0.72, 0.46  
 EPHX1 rs1051740 = 0 157 −0.23 − 0.51, 0.06 0.54 137 −0.39 − 0.92, 0.15 0.91
 EPHX1 rs1051740 = 1 125 −0.09 − 0.40, 0.22   103 −0.33 − 0.86, 0.20  
 GSTP1 rs1695 = 0 121 −0.13 − 0.43, 0.17 0.31 101 −0.29 − 0.83, 0.25 0.84
 GSTP1 rs1695 = 1 163 −0.23 − 0.50, 0.05   142 −0.46 − 0.96, 0.04  
 GSTP1 rs1138272 = 0 228 −0.16 − 0.38, 0.06 0.39 197 −0.26 − 0.64, 0.13 0.34
 GSTP1 rs1138272 = 1 51 −0.44 −1.20, 0.33   42 −0.87 −1.81, 0.07  
 Sum of 3 CYP2E1 SNPs = 0 160 −0.16 −0.46, 0.14 0.24 135 −0.58 −1.01, − 0.06 0.15
 Sum of 3 CYP2E1 SNPs ≥1 100 −0.16 −0.41, 0.10   85 0.02 −0.46, 0.51  
 Sum of 2 GSTP1 SNPs = 0 113 −0.07 −0.40, 0.26 0.70 95 −0.27 −0.82, 0.29 0.59
 Sum of 2 GSTP1 SNPs ≥1 164 −0.27 −0.54, 0.00   143 −0.49 −0.96, − 0.01  
  1. Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery
  2. a0 = homozygous wildtype, 1 = 1 or 2 variant alleles for SNPs