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Table 6 Associations between SNPs in acrylamide-metabolising genes and the ratio of glycidamide to acrylamide hemoglobin adducts

From: Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

SNP ID

n

Homozygous wildtype

n

Heterozygous

p

n

Homozygous variant allele

p

Regression coefficient (95% CI)

Regression coefficient (95% CI)

Regression coefficient (95% CI)

All

 rs915906, CYP2E1

196

Ref

78

0.004

(−0.07, 0.08)

0.91

6

−0.12

(− 0.37, 0.14)

0.37

 rs2480258, CYP2E1

174

Ref

99

0.04

(−0.03, 0.10)

0.30

9

−0.06

(− 0.26, 0.14)

0.56

 rs11101888, CYP2E1

234

Ref

47

−0.04

(− 0.13, 0.05)

0.35

1

0.83

(0.34, 1.32)

0.001

 rs1051740, EPHX1

157

Ref

107

−0.05

(− 0.12, 0.01)

0.10

25

−0.05

(− 0.16, 0.06)

0.36

 rs1695, GSTP1

125

Ref

140

−0.04

(− 0.11, 0.02)

0.19

26

0.01

(−0.12, 0.13)

0.93

 rs1138272, GSTP1

234

Ref

50

−0.01

(− 0.10, 0.07)

0.77

2

0.20

(−0.15, 0.55)

0.27

Non-smokers

 rs915906, CYP2E1

169

Ref

64

0.03

(−0.06, 0.11)

0.56

6

−0.11

(− 0.38, 0.16)

0.43

 rs2480258, CYP2E1

148

Ref

84

0.05

(−0.03, 0.12)

0.21

8

−0.11

(− 0.34, 0.13)

0.38

 rs11101888, CYP2E1

199

Ref

40

−0.04

(− 0.14, 0.07)

0.48

1

0.84

(0.32, 1.36)

0.002

 rs1051740, EPHX1

137

Ref

87

−0.07

(− 0.14, 0.01)

0.08

22

−0.05

(− 0.17, 0.07)

0.39

 rs1695, GSTP1

105

Ref

121

−0.05

(− 0.12, 0.03)

0.20

23

0.02

(−0.12, 0.16)

0.76

 rs1138272, GSTP1

202

Ref

41

−0.02

(− 0.12, 0.08)

0.69

2

0.14

(−0.16, 0.44)

0.36

  1. Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery