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Table 6 Associations between SNPs in acrylamide-metabolising genes and the ratio of glycidamide to acrylamide hemoglobin adducts

From: Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes

SNP ID n Homozygous wildtype n Heterozygous p n Homozygous variant allele p
Regression coefficient (95% CI) Regression coefficient (95% CI) Regression coefficient (95% CI)
All
 rs915906, CYP2E1 196 Ref 78 0.004
(−0.07, 0.08)
0.91 6 −0.12
(− 0.37, 0.14)
0.37
 rs2480258, CYP2E1 174 Ref 99 0.04
(−0.03, 0.10)
0.30 9 −0.06
(− 0.26, 0.14)
0.56
 rs11101888, CYP2E1 234 Ref 47 −0.04
(− 0.13, 0.05)
0.35 1 0.83
(0.34, 1.32)
0.001
 rs1051740, EPHX1 157 Ref 107 −0.05
(− 0.12, 0.01)
0.10 25 −0.05
(− 0.16, 0.06)
0.36
 rs1695, GSTP1 125 Ref 140 −0.04
(− 0.11, 0.02)
0.19 26 0.01
(−0.12, 0.13)
0.93
 rs1138272, GSTP1 234 Ref 50 −0.01
(− 0.10, 0.07)
0.77 2 0.20
(−0.15, 0.55)
0.27
Non-smokers
 rs915906, CYP2E1 169 Ref 64 0.03
(−0.06, 0.11)
0.56 6 −0.11
(− 0.38, 0.16)
0.43
 rs2480258, CYP2E1 148 Ref 84 0.05
(−0.03, 0.12)
0.21 8 −0.11
(− 0.34, 0.13)
0.38
 rs11101888, CYP2E1 199 Ref 40 −0.04
(− 0.14, 0.07)
0.48 1 0.84
(0.32, 1.36)
0.002
 rs1051740, EPHX1 137 Ref 87 −0.07
(− 0.14, 0.01)
0.08 22 −0.05
(− 0.17, 0.07)
0.39
 rs1695, GSTP1 105 Ref 121 −0.05
(− 0.12, 0.03)
0.20 23 0.02
(−0.12, 0.16)
0.76
 rs1138272, GSTP1 202 Ref 41 −0.02
(− 0.12, 0.08)
0.69 2 0.14
(−0.16, 0.44)
0.36
  1. Adjusted for: maternal pre-pregnancy BMI (kg/m2), maternal weight gain during pregnancy, maternal smoking during pregnancy (n cigarettes/day), parity (n children), gestational age (weeks), newborn’s sex and date of delivery