Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China

Table 1 The association between SIRT1 SNPs with mortality

Minor allele copy number	n	HR (95% CI)	p value
SIRT1_366 (n = 7055)
Additive model
0	5281	Ref
1	1635	1.050 (0.963,1.146)	0.269
2	139	1.209 (0.905,1.615)	0.199
Dominant model
0	5281	Ref
1 or 2	1774	1.059 (0.973,1.153)	0.182
Recessive model
0 or 1	6916	Ref
2	139	1.195 (0.895,1.595)	0.227
SIRT1_391 (n = 7077)
Additive model
0	5006	Ref
1	1887	1.023 (0.942,1.111)	0.589
2	184	0.769 (0.603,0.981)	0.035
Dominant model
0	5006	Ref
1 or 2	2071	0.997 (0.92,1.081)	0.947
Recessive model
0 or 1	6893	Ref
2	184	0.764 (0.599,0.974)	0.030
SIRT1_773 (n = 7071)
Additive model
0	3795	Ref
1	2743	0.993 (0.919,1.072)	0.854
2	533	0.960 (0.825,1.117)	0.597
Dominant model
0	3795	Ref
1 or 2	3276	0.988 (0.918,1.064)	0.748
Recessive model
0 or 1	6538	Ref
2	533	0.963 (0.831,1.116)	0.616
SIRT1_720 (n = 7046)
Additive model
0	2292	Ref
1	3383	1.045 (0.961,1.137)	0.302
2	1371	1.013 (0.910,1.127)	0.814
Dominant model
0	2292	Ref
1 or 2	4754	1.036 (0.957,1.121)	0.383
Recessive model
0 or 1	5675	Ref
2	1371	0.986 (0.898,1.083)	0.774

Note: All models were adjusted for age at baseline, sex, education, marriage, occupation, residence, exercise, smoking, and alcohol consumption

ISSN: 1476-069X