|
Minor allele copy number
|
n
|
HR (95% CI)
|
p value
|
|---|
|
SIRT1_366 (n = 7055)
|
|
Additive model
|
|
0
|
5281
|
Ref
| |
|
1
|
1635
|
1.050 (0.963,1.146)
|
0.269
|
|
2
|
139
|
1.209 (0.905,1.615)
|
0.199
|
|
Dominant model
|
|
0
|
5281
|
Ref
| |
|
1 or 2
|
1774
|
1.059 (0.973,1.153)
|
0.182
|
|
Recessive model
|
|
0 or 1
|
6916
|
Ref
| |
|
2
|
139
|
1.195 (0.895,1.595)
|
0.227
|
|
SIRT1_391 (n = 7077)
|
|
Additive model
|
|
0
|
5006
|
Ref
| |
|
1
|
1887
|
1.023 (0.942,1.111)
|
0.589
|
|
2
|
184
|
0.769 (0.603,0.981)
|
0.035
|
|
Dominant model
|
|
0
|
5006
|
Ref
| |
|
1 or 2
|
2071
|
0.997 (0.92,1.081)
|
0.947
|
|
Recessive model
|
|
0 or 1
|
6893
|
Ref
| |
|
2
|
184
|
0.764 (0.599,0.974)
|
0.030
|
|
SIRT1_773 (n = 7071)
|
|
Additive model
|
|
0
|
3795
|
Ref
| |
|
1
|
2743
|
0.993 (0.919,1.072)
|
0.854
|
|
2
|
533
|
0.960 (0.825,1.117)
|
0.597
|
|
Dominant model
|
|
0
|
3795
|
Ref
| |
|
1 or 2
|
3276
|
0.988 (0.918,1.064)
|
0.748
|
|
Recessive model
|
|
0 or 1
|
6538
|
Ref
| |
|
2
|
533
|
0.963 (0.831,1.116)
|
0.616
|
|
SIRT1_720 (n = 7046)
|
|
Additive model
|
|
0
|
2292
|
Ref
| |
|
1
|
3383
|
1.045 (0.961,1.137)
|
0.302
|
|
2
|
1371
|
1.013 (0.910,1.127)
|
0.814
|
|
Dominant model
|
|
0
|
2292
|
Ref
| |
|
1 or 2
|
4754
|
1.036 (0.957,1.121)
|
0.383
|
|
Recessive model
|
|
0 or 1
|
5675
|
Ref
| |
|
2
|
1371
|
0.986 (0.898,1.083)
|
0.774
|
- Note: All models were adjusted for age at baseline, sex, education, marriage, occupation, residence, exercise, smoking, and alcohol consumption
