Fig. 1

Reduced core body temperature in female mice exposed during early development to DDTs or p,p’-DDE. a Schematic diagram of experimental design, including timing of exposure from GD11.5 to P5, and age-specific measurement and analyses in blue. b, c Core body temperature measured at 5, 11, and 15 weeks in female (b) and male (c) offspring to assess impairment of thermogenic phenotype in maturing and adult mice. Data presented as mean ± SE, n = 14 (VEH), 15 (DDTs) or 7 (p,p’-DDE) non-littermates/group at each time point. Statistical significance (* = DDTs, # = p,p’-DDE) at p < 0.05 vs age-matched Veh control. Veh, vehicle (organic olive oil); DDT, dichlorodiphenyltrichloroethane; DDE, dichlorodiphenyldichloroethylene; GD11.5, gestational day 11.5; P5, postnatal day 5; wks, weeks; mo, months; IF, immunofluorescence