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Table 1 Organization of lines of evidence for adversity and endocrine activity

From: Assessment of the endocrine disrupting properties of bisphenol AF: a case study applying the European regulatory criteria and guidance

Adversity

Endocrine activity

EATS-mediated

In vitro mechanistic

EATS-sensitive but not diagnostic

In vivo mechanistic (mammals)

General toxicity

In vivo mechanistic (non-mammals)