Table 3 Overview of the integrated lines of evidence for adversity in mammals, classified by the weight of evidence evaluation as strong, moderate, weak, or no evidence for effect and the study IDs. For detailed information and data on general toxicity, see supplemental material - Appendix B

Strong

■Estrous cycling disruption (adult exposure) IDs: 60, 83, 88

■Mammary gland histopathology alteration in female (developmental exposure) ID: 59

■Ovary histopathology alteration (adult exposure) IDs: 83, 88

■Testis histopathology alteration (adult exposure) IDs: 60, 88

■Prostate weight decrease (adult exposure) ID: 60

■Epididymis weight decrease (adult exposure) ID: 88

■Seminal vesicles weight decrease (adult exposure) ID: 60

■Seminal vesicles histopathology alteration (adult exposure) ID: 88

■Brain weight increase in male and female (adult exposure) IDs: 60, 88

■Adrenals weight increase in male (adult exposure) IDs: 60, 88

■Adrenals histopathology alteration in male (adult exposure) IDs: 60, 88

■Pituitary gland histopathology alteration in male (adult exposure) IDs: 60, 88

■Fertility decrease in male (adult exposure) ID: 88

■Developmental neurotoxicity: behaviour alterations ID: 57

Moderate

■Mammary gland histopathology alteration in female (adult exposure) IDs: 60, 88

■Mammary gland histopathology alteration in male (adult exposure) IDs: 60, 88

■Ovary weight decrease (adult exposure) IDs: 83, 88

Weak

■Testis weight decrease (adult exposure) IDs: 55, 88

■Adrenals histopathology alteration in female (adult exposure) IDs: 60, 88

No evidence for effect

■Estrous cycling alteration (developmental exposure) ID: 59

■Uterus weight alteration (pregnant exposure) ID: 88

■Uterus histopathology alteration (pregnant exposure) ID: 88

■Vaginal opening alteration (gestational exposure) ID: 59

■Vagina histopathology alteration (adult exposure) ID: 88

■Testis weight alteration (developmental exposure) ID: 58

■Epididymis weight alteration (developmental exposure) IDs: 58, 84

■Sperm morphology alteration (adult exposure) ID: 60

■Thyroid weight alteration in male and female (adult exposure) IDs: 60, 88

■Adrenals weight alteration in females (adult exposure) IDs: 60, 88

■Pituitary gland histopathology alteration in females (adult exposure) IDs: 60, 88

■Time to mating alteration in males and females (adult exposure) ID: 88

■Gestation length alteration (gestational exposure) ID: 88

■Sex ratio alteration (gestational exposure) ID: 58

■Litter size alteration (gestational exposure) IDs: 56, 58, 84, 88

■Litter viability alteration (gestational exposure) IDs: 56, 58

■Litter/pup weight alteration (gestational exposure) ID: 58

■Pup survival index alteration (gestational exposure) ID: 58

■Pup development alteration (gestational exposure) ID: 88