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Table 3 Associations between blood cadmium concentrations (per 0.1 µg/L) and reproductive hormones and metabolic markers, adjusting for dietary factors

From: Associations between blood cadmium and endocrine features related to PCOS-phenotypes in healthy women of reproductive age: a prospective cohort study

 

Adjusted for rice

Adjusted for grains

Adjusted for green vegetables

 

%Difference (95 % CI)

%Difference (95 % CI)

%Difference (95 % CI)

Reproductive hormones

Testosterone

2.2 (0.4, 4.1)*

2.2 (0.4, 4.1)*

2.2 (0.4, 4.1)*

Free testosterone

1.3 (-0.4, 3.0)

1.3 (-0.4, 3.0)

1.3 (-0.4, 3.0)

Free androgen index

-0.7 (-3.0, 1.7)

-0.8 (-3.2, 1.6)

-0.8 (-3.1, 1.6)

SHBG

2.9 (0.4, 5.4)*

3.0 (0.6, 5.6)*

3.0 (0.5, 5.5)*

AMH

6.1 (-0.5, 13.1)

7.6 (0.9, 14.8)*

7.6 (0.9, 14.7)*

Metabolic markers

Insulin

-1.3 (-3.2, 0.7)

-1.3 (-3.2, 0.6)

-1.3 (-3.2, 0.6)

Glucose

0.1 (-0.2, 0.4)

0.1 (-0.3, 0.4)

0.1 (-0.2, 0.4)

HOMA-IR

-1.2 (-3.2, 0.9)

-1.2 (-3.2, 0.8)

-1.2 (-3.2, 0.8)

  1. Note: All models were adjusted for age, BMI, race, parity, and smoking. *P<0.05
  2. AMH anti Müllerian hormone, BMI body mass index, CI confidence interval, HOMA-IR homeostatic model assessment of insulin resistance, SHBG sex hormone-binding globulin