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Table 2 Association Between Occupational Exposure to PAHs and Prostate Cancer Risk, PROtEuS, 2005–2012

From: Occupational exposure to polycyclic aromatic hydrocarbons and risk of prostate cancer

Exposure

 

Prostate cancer

n Controls

n Cases

ORa

95%CI

PAHs from any source

 Never exposed

1053

1009

1.00

Ref

 Ever exposed

573

560

1.00

(0.85, 1.18)

 Duration (per 5-year increment)

573

560

1.00

(0.97, 1.03)

 Cumulative exposure

  0.01—300.00

303

293

0.99

(0.81, 1.20)

  300.01—1049.66

125

130

1.03

(0.78, 1.37)

   > 1049.66

143

137

1.01

(0.76, 1.33)

  p for trend

  

0.93

 

Benzo[a]pyrene

 Ever exposed

188

182

1.00

(0.78, 1.26)

 Duration (per 5-year increment)

188

182

0.97

(0.92, 1.03)

 Cumulative exposure

  0.01—226.95

94

103

1.12

(0.81, 1.55)

  226.96—588.00

42

42

1.03

(0.64, 1.65)

   > 588.00

52

37

0.73

(0.45, 1.20)

  p for trend

  

0.25

 

PAHs from petroleum

 Ever exposed

516

514

1.01

(0.85, 1.19)

 Duration (per 5-year increment)

516

514

1.01

(0.97, 1.04)

 Cumulative exposure

  0.01—240.50

266

278

1.06

(0.86, 1.30)

  240.51—901.00

120

115

0.89

(0.67, 1.20)

   > 901.00

130

121

1.02

(0.76, 1.37)

  p for trend

  

0.93

 

PAHs from wood

 Ever exposed

42

50

1.24

(0.79, 1.95)

 Duration (per 5-year increment)

42

50

1.06

(0.95, 1.18)

 Cumulative exposure

  0.01—450.00

21

24

1.13

(0.60, 2.16)

  450.01—1732.50

10

8

0.94

(0.33, 2.66)

   > 1732.50

11

18

1.54

(0.60, 3.92)

  p for trend

  

0.32

 

PAHs from coal

 Ever exposed

57

57

0.97

(0.66, 1.44)

 Duration (per 5-year increment)

57

57

0.95

(0.87, 1.04)

 Cumulative exposure

  0.01—142.50

30

36

1.15

(0.68, 1.95)

  142.51—546.25

12

14

1.18

(0.52, 2.70)

   > 546.25

15

7

0.46

(0.18, 1.17)

  p for trend

  

0.12

 

PAHs from other sources

 Ever exposed

88

91

0.95

(0.68, 1.31)

 Duration (per 5-year increment)

88

91

1.01

(0.94, 1.08)

 Cumulative exposure

  0.01—200.00

44

41

0.89

(0.56, 1.41)

  200.01—725.00

21

19

0.73

(0.37, 1.42)

   > 725.00

23

31

1.19

(0.62, 2.30)

  p for trend

  

0.59

 
  1. Abbreviations: OR Odds ratio, PAHs Polycyclic aromatic hydrocarbons, CI Confidence interval
  2. aOR adjusted for age, ancestry, education, alcohol drinking, cigarette smoking, body mass index, consumption of fried or grilled food, occupational exposure to benzene, farming, and workplace environmental tobacco smoke