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Table 4 Association between single-nucleotide polymorphisms (SNPs) in fetal SOD2 and MTHFR and risk for neural tube defects

From: Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case–control study

SNP and genotype

Controls [n (%)]

Cases [n (%)]

OR (95% CI)

P

SOD2 rs4880

 AA

104 (72.2)

125 (80.6)

1

 

 AG

35 (24.3)

29 (18.7)

0.69 (0.40–1.20)

0.190

 GG

5 (3.5)

1 (0.6)

0.17 (0.02–1.45)

0.104

 P for trend

   

0.045

MTHFR rs1801133

 CC

24 (16.7)

18 (11.6)

1

 

 CT

78 (54.5)

78 (50.3)

1.33 (0.67–2.65)

0.412

 TT

41 (28.7)

59 (38.1)

1.92 (0.93–3.98)

0.080

 P for trend

   

0.059

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Environmental Health

ISSN: 1476-069X