Table 5 Differentially methylated positions (DMPs) and differentially variable positions (DVPs) in meta-analyses. DMPs and DVPs (FDR < 0.05) in the PBMC meta-analysis (i.e., including the Chile PBMC study, Bangladesh 450 K study, and Bangladesh 850 K study) and PBMC + buccal cell meta-analysis (i.e., including the Chile buccal cell study) adjusted for age, smoking status, cell type proportions, and sex (in the Chile studies). CpGs identified in multiple meta-analyses are bolded

  cg13490635

0.31

+ + +

6.30e-08

0.024

8

30,242,021

RBPMS;RBPMS

5’UTR;1stExon

  cg09275980

0.31

+ + + +

2.52e-07

0.042

15

25,350,925

SNORD116–29

TSS1500

  cg20784693

−0.64

----

3.08e-07

0.042

2

239,984,030

HDAC4

Body

  cg18263451

−0.12

- - + −

3.31e-07

0.042

1

25,573,180

C1orf63

Body

 cg23281729

0.97

- + +

2.86E-11

1.08E-05

18

78,005,477

PARD6G

TSS200

  cg27425262

0.82

+ + +

2.26E-08

0.004

2

113,953,981

PSD4;LOC440839

Body;Body

  cg11361658

0.17

+ + +

6.94E-08

0.009

5

128,452,311

  cg03205258

0.69

+ + +

9.72E-08

0.009

22

19,929,274

TXNRD2;COMT; COMT

1stExon;1stExon; 5’UTR

  cg09692492

−0.35

---

1.36E-07

0.010

22

23,744,717

ZDHHC8P

Body

  cg11032634

0.77

+ + +

3.06E-07

0.019

22

19,929,254

TXNRD2;COMT

1stExon;TSS200

  cg16511076

0.13

+ + +

4.07E-07

0.022

4

48,887,480

OCIAD2

3’UTR

  cg22387890

0.55

+ + +

5.44E-07

0.023

7

6,145,595

USP42

5’UTR

  cg22749736

0.13

+ + +

5.53E-07

0.023

11

1,306,759

TOLLIP

Body

  cg04080724

0.14

+ + +

6.06E-07

0.023

4

140,202,327

C4orf49

TSS1500

  cg05169951

0.23

+ + +

6.99E-07

0.024

16

3,017,955

KREMEN2;PAQR4

Body;TSS1500

  cg00668103

0.14

+ + +

8.08E-07

0.025

7

100,084,730

C7orf51

Body

  cg08207566

0.12

+ + +

1.04E-06

0.030

4

174,086,461

  cg01101647

0.13

+ + +

1.13E-06

0.030

4

66,535,732

EPHA5

TSS200

  cg07611790

0.11

+ + +

1.25E-06

0.031

19

49,240,823

RASIP1

Body

  cg11691429

0.21

+ + +

1.39E-06

0.031

2

947,634

SNTG2

Body

  cg21185289

0.38

+ + +

1.45E-06

0.031

2

74,743,437

TLX2

3’UTR

  cg08285768

0.11

+ + +

1.48E-06

0.031

15

86,038,622

AKAP13

Body

  cg13972353

0.15

+ + +

1.57E-06

0.031

9

139,354,348

SEC16A

Body

  cg06740986

0.11

+ + +

2.08E-06

0.039

1

184,838,417

FAM129A

Body

  cg21857098

0.12

+ + +

2.46E-06

0.043

15

25,638,137

UBE3A

Body

  cg03479942

0.13

+ + +

2.50E-06

0.043

16

69,341,763

SNTB2

3’UTR

  cg07984508

0.11

+ + +

2.73E-06

0.045

15

77,426,719

SGK269

Body

  cg23281729

0.99

−+++

2.00E-14

7.51E-09

18

78,005,477

PARD6G

TSS200

  cg27425262

0.90

+ + + +

4.52E-13

8.53E-08

2

113,953,981

PSD4;LOC440839

Body;Body

  cg03205258

0.64

+ + + +

7.95E-09

0.001

22

19,929,274

TXNRD2;COMT; COMT

1stExon;1stExon; 5’UTR

  cg11032634

0.70

+ + + +

5.69E-08

0.006

22

19,929,254

TXNRD2;COMT

1stExon;TSS200

  cg04080724

0.14

+ + + +

1.14E-07

0.009

4

140,202,327

C4orf49

TSS1500

  cg26384602

−0.12

----

1.87E-07

0.010

19

41,798,386

HNRNPUL1

Body

  cg11361658

0.16

+ + + +

1.90E-07

0.010

5

128,452,311

  cg09692492

−0.30

----

2.32E-07

0.011

22

23,744,717

ZDHHC8P

Body

  cg22749736

0.12

+ + + +

4.20E-07

0.018

11

1,306,759

TOLLIP

Body

  cg21921619

−0.15

-+--

5.48E-07

0.021

10

116,852,791

ATRNL1

TSS1500

  cg07935287

−0.13

----

7.91E-07

0.026

18

54,318,347

WDR7

TSS1500

  cg05169951

0.22

+ + + +

8.19E-07

0.026

16

3,017,955

KREMEN2;PAQR4

Body;TSS1500

  cg21185289

0.37

+ + + +

1.01E-06

0.030

2

74,743,437

TLX2

3’UTR

  cg22387890

0.48

+ + + +

1.12E-06

0.030

7

6,145,595

USP42

5’UTR

  cg13171197

0.12

+ − + +

1.46E-06

0.037

7

90,916,020

  cg24754507

−0.10

----

1.55E-06

0.037

6

28,481,862

GPX6

Body

  cg00355447

0.14

+ + + +

1.80E-06

0.039

6

30,292,220

HCG18

Body

  cg16511076

0.12

+ + + −

1.87E-06

0.039

4

48,887,480

OCIAD2

3’UTR

  cg04873963

−0.10

----

2.46E-06

0.049

16

2,518,322