Table 6 Differentially methylated regions (DMRs) and differentially variable regions (DVRs) in meta-analyses. DMRs and DVRs in the PBMC meta-analysis (i.e., including the Chile PBMC study, Bangladesh 450 K study, and Bangladesh 850 K study) and PBMC + buccal cell meta-analysis (i.e., including the Chile buccal cell study) adjusted for age, smoking status, cell type proportions, and sex (in the Chile studies). Genes identified in multiple meta-analyses are bolded
Chromosome | Start | End | N probes | Sidak p | Gene |
|---|---|---|---|---|---|
DMRs | |||||
 PBMCs | |||||
  10 | 134,150,451 | 134,150,760 | 7 | 1.47E-09 | LRRC27 |
  7 | 27,231,819 | 27,232,150 | 3 | 1.20E-07 | HOXA13 |
  10 | 91,295,045 | 91,295,650 | 11 | 1.35E-07 | SLC16A12 |
  7 | 27,225,733 | 27,226,148 | 7 | 8.99E-07 | HOXA11-AS |
  8 | 23,563,925 | 23,564,294 | 8 | 1.26E-05 | NKX2–6 |
  1 | 203,320,190 | 203,320,541 | 6 | 1.35E-05 | FMOD |
  11 | 15,095,017 | 15,095,178 | 6 | 5.68E-05 | CALCB |
  16 | 88,747,591 | 88,747,919 | 4 | 7.15E-05 | SNAI3-AS1;SNAI3 |
  15 | 83,953,690 | 83,953,883 | 10 | 3.77E-05 | BNC1 |
  13 | 51,640,142 | 51,640,442 | 5 | 1.15E-04 | GUCY1B2 |
  19 | 49,220,102 | 49,220,235 | 4 | 5.36E-04 | MAMSTR |
 PBMCs + buccal cells | |||||
  10 | 134,150,451 | 134,150,760 | 7 | 3.42E-10 | LRRC27 |
  7 | 27,225,543 | 27,226,148 | 8 | 4.17E-09 | HOXA11-AS |
  7 | 27,231,819 | 27,232,150 | 3 | 1.04E-08 | HOXA13 |
  1 | 203,320,190 | 203,320,541 | 6 | 3.72E-08 | FMOD |
  11 | 15,095,017 | 15,095,178 | 6 | 9.60E-07 | CALCB |
  16 | 88,747,591 | 88,747,919 | 4 | 3.93E-07 | SNAI3-AS1;SNAI3 |
  8 | 23,563,925 | 23,564,294 | 8 | 2.69E-05 | NKX2–6 |
  2 | 207,139,131 | 207,139,445 | 6 | 0.001 | ZDBF2 |
  1 | 247,537,159 | 247,537,369 | 3 | 1.75E-05 | LOC107985115 |
  8 | 145,638,881 | 145,639,181 | 3 | 3.34E-05 | SLC39A4 |
  16 | 85,518,901 | 85,519,061 | 3 | 0.073 | GSE1 |
  17 | 17,603,837 | 17,604,184 | 3 | 5.40E-05 | RAI1 |
  6 | 28,584,003 | 28,584,155 | 10 | 0.001 | ZBED9 |
  19 | 49,220,102 | 49,220,235 | 4 | 5.36E-04 | MAMSTR |
  7 | 120,968,877 | 120,969,174 | 8 | 1.20E-04 | WNT16 |
  19 | 44,488,121 | 44,488,269 | 5 | 9.10E-04 | ZNF155 |
DVRs | |||||
 PBMCs | |||||
  22 | 19,929,066 | 19,929,557 | 9 | 4.27E-13 | TXNRD2;COMT;TXNRD2 |
  16 | 1,844,927 | 1,845,113 | 6 | 3.56E-11 | IGFALS |
  22 | 39,784,481 | 39,784,982 | 5 | 7.84E-09 | SYNGR1 |
  3 | 8,809,306 | 8,809,715 | 4 | 6.66E-08 | OXTR |
  2 | 947,515 | 947,634 | 3 | 6.36E-07 | SNTG2 |
  2 | 48,844,728 | 48,844,984 | 6 | 5.84E-06 | STON1-GTF2A1L;GTF2A1L |
  3 | 48,700,269 | 48,700,498 | 8 | 2.02E-05 | CELSR3 |
  12 | 9,217,529 | 9,217,859 | 7 | 4.45E-05 | LINC00612;A2M-AS1 |
  16 | 53,407,423 | 53,407,808 | 5 | 7.37E-05 | LOC102723373 |
  10 | 134,150,451 | 134,150,760 | 7 | 6.52E-05 | LRRC27 |
  6 | 90,597,340 | 90,597,591 | 4 | 1.20E-04 | GJA10 |
 PBMCs + buccal cells | |||||
  22 | 19,929,066 | 19,929,557 | 9 | 5.12E-13 | TXNRD2;COMT;TXNRD2 |
  6 | 30,038,882 | 30,039,600 | 25 | 1.49E-09 | RNF39 |
  6 | 32,064,656 | 32,065,043 | 16 | 4.68E-06 | TNXB |
  3 | 8,809,306 | 8,809,715 | 4 | 1.90E-07 | OXTR |
  5 | 178,986,291 | 178,986,728 | 6 | 1.16E-05 | RUFY1 |
  6 | 31,651,070 | 31,651,291 | 5 | 0.079 | LY6G5C |
  22 | 39,784,769 | 39,784,982 | 3 | 1.57E-05 | SYNGR1 |
  2 | 48,844,728 | 48,844,984 | 6 | 1.45E-05 | STON1-GTF2A1L;GTF2A1L |
  6 | 32,551,749 | 32,552,042 | 3 | 1.72E-05 | HLA-DRB1 |
  12 | 9,217,529 | 9,217,859 | 7 | 4.29E-05 | LINC00612;A2M-AS1 |
  2 | 947,515 | 947,634 | 3 | 7.33E-05 | SNTG2 |
  18 | 59,221,320 | 59,221,601 | 3 | 3.20E-05 | CDH20 |
  16 | 1,844,927 | 1,845,113 | 6 | 6.80E-05 | IGFALS |
  6 | 168,106,055 | 168,106,326 | 4 | 5.79E-05 | LINC02487 |
  16 | 53,407,423 | 53,407,753 | 4 | 5.41E-04 | LOC102723373 |
  7 | 157,667,762 | 157,668,051 | 4 | 8.85E-05 | PTPRN2 |
  10 | 134,150,451 | 134,150,760 | 7 | 8.96E-05 | LRRC27 |
  19 | 37,825,307 | 37,825,446 | 6 | 4.27E-04 | ZNF875 |
  19 | 36,246,816 | 36,246,906 | 3 | 8.87E-04 | HSPB6 |