Skip to main content

Table 4 Distribution of inflammatory mediators (pg/mL) in AE-IPF and stable patients

From: Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis

Inflammatory mediators (pg/mL) Median (IQR)
Whole cohort (n = 93) Patients residing in the Greater Athens Area (n = 51) Patients residing out of the Greater Athens Area (n = 42)
All patients
(n = 93)
AE-IPF
(n = 49)
Stable patients
(n = 44)
All patients
(n = 51)
AE-IPF
(n = 32)
Stable patients
(n = 19)
All patients
(n = 42)
AE-IPF
(n = 22)
Stable patients
(n = 20)
IL-1a 3.2 (24.3) 3.2 (38.3) 3.2 (0.0) 3.2 (36.6) 3.2 (102.4) 3.2 (0) 3.2 (24.4) 3.2 (17) 3.2 (23.8)
IL-1b 2.8 (2.6) 3.2 (2.6) 1.3 (2.7) 3.2 (2.5) 3.2 (2.3) 1.4 (2.6) 1.1 (2.7) 0.9 (2.8) 1 (2.7)
IL-4 0.5 (1.1) 2 (11.7) 9.8 (25) 2 (13.3) 1.8 (10.8) 9.8 (29) 9.7 (19.3) 10.9 (19.2) 10.1 (23.5)
IL-5 7.8 (15.8) 2 (2.7) 1.6 (1.5) 1.8 (3.2) 2 (3.1) 1.7 (2.2) 1.6 (2) 1.7 (3.6) 1.5 (1.2)
IL-6 1.7 (2.2) 4.3 (9.7) 1.6 (2.4) 3.3 (8.9) 4.3 (13.9) 2.1 (3.4) 2.4 (4.5) 3.9 (6.6) 1.5 (3.4)
IL-8 2.8 (5.2) 10.9 (16.1) 5.1 (5.8) 7.3 (10.5) 10.9 17.3) 5.4 (5.3) 6.5 (8.9) 10.9 (16.5) 4.7 (5.4)
IL-10 7.0 (9.4) 4.7 (8.9) 4.0 (7.3) 4.4 (6.8) 4.5 (8.1) 4 (6.5) 4.5 (10.1) 5.8 (13.8) 3.9 (7.4)
IL-13 4.4 (8.1) 2.1 (5.4) 0.2 (2.0) 1.1 (5.4) 1.7 (5.2) 0.6 (8.8) 0.3 (2.6) 2.7 (11.4) 0.2 (1.3)
MCP-1 338.6 (186.6) 359 (232) 311 (169) 324 (209) 316 (232) 328 (177) 3701 (185) 432 (2601) 288 (185)
MIP-1a 16.0 (23.7) 17.5 (25.7) 10.4 (15.7) 16.9 (26.9) 18.1 (29.2) 11.4 (16.5) 12.2 (20.6) 12.9 (26.2) 9.9 (18.3)
MIP-4 555.0 (268.5) 543 (361) 564 (248) 615 (352) 608 (495) 593 (254) 504 (209) 502 (227) 527 (235)
MMP1 1691 (2189) 1998 (3459) 1185 (1746) 1878 (2711) 1938 (3394) 1690 (2306) 1476 (2053) 2032 (3414) 1067 (1192)
MMP7 2875 (8070) 680 (7644) 8156 (8229) 548 (8035) 548 (6729) 8227 (8612) 7904 (8070) 4755 (7690) 8084 (8097)
MMP9 71,941 (50,498) 74,697 (45,764) 61,817 (44,036) 76,638 (60,233) 74,331 (67,302) 86,489 (60,936) 59,883 (39,402) 75,441 (43,656) 57,949.5 (30,739.2)
TNFa 3.9 (5.1) 3.9 (5.5) 3.6 (5.2) 4 (4.7) 3.9 (4.1) 5.1 (4.7) 3.4 (7.2) 6.1 (7.9) 2.6 (3.9)
TGFb1 6847 (19,363) 7148 (24,161) 6202 (15,300) 7148 (23,122) 7226 (24,052) 5583 (12,605) 5990 (19,013) 6292 (29,717) 6481 (15,844)
OPN 25,581 (46,783) 31,149 (37,819) 23,534 (54,128) 23,539 (50,807) 25,124 (41,382) 15,113 (60,563) 27,263 (40,751) 39,117 (40,684) 25,620 (69,001)
  1. AE-IPF Acute Exacerbation of Idiopathic Pulmonary Fibrosis, IQR Inter-quartile range