Table 3 Serum metabolites associated with patella and tibia Pb

Significant in patella and tibia

5-Aminopentanoic acid

-0.049 (0.015)

1.82E-03

-0.049 (0.022)

2.46E-02

 L-Arginine

-0.010 (0.005)

4.70E-02

-0.015 (0.007)

2.74E-02

Significant in patella

Betaine

0.031 (0.009)

5.31E-04***

0.018 (0.014)

0.19

Biliverdin

0.017 (0.007)

1.97E-02

0.007 (0.010)

0.45

Oxoproline

0.012 (0.005)

2.05E-02

0.004 (0.007)

0.60

Pyroglutamate

0.012 (0.005)

2.09E-02

0.004 (0.007)

0.60

7-Methylguanine

-0.004 (0.002)

3.29E-02

-0.003 (0.003)

0.34

POV-PC

-0.018 (0.008)

3.42E-02

-0.022 (0.011)

0.05

Significant in tibia

1-Linoleoylglycerol

0.016 (0.012)

0.18

0.049 (0.015)

1.50E-03*

Glycochenodeoxycholic acid

0.009 (0.012)

0.44

0.044 (0.016)

6.83E-03

Docosahexaenoic acid (DHA)

-0.009 (0.006)

0.16

-0.022 (0.008)

9.21E-03

Allantoin

-0.011 (0.007)

0.13

-0.026 (0.010)

9.56E-03

Glycocholic acid

0.015 (0.011)

0.18

0.037 (0.015)

1.74E-02

MEP (Mono-ethyl phthalate)

0.025 (0.027)

0.36

0.085 (0.037)

2.32E-02

Oleoyl-Glycerol

-0.011 (0.010)

0.26

-0.030 (0.013)

2.79E-02

1-Arachidonoylglycerol

0.006 (0.007)

0.34

0.020 (0.009)

2.89E-02

 L-Isoleucine

0.007 (0.005)

0.17

0.014 (0.007)

3.66E-02

Indole-3-Carboxylic acid

0.004 (0.006)

0.54

-0.017 (0.008)

3.82E-02

Erucic acid

-0.006 (0.006)

0.32

-0.017 (0.008)

3.96E-02

2-Undecanone

0.008 (0.005)

0.07

0.013 (0.006)

4.10E-02