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Table 1 Participant Characteristics and Distribution of Higher Urine 2,4-D Concentrations. Legend: Distribution of high (> 0.4 μg/L urine) 2,4-D urinary concentrations and associations with key variables in unadjusted models. * = reference level

From: Association between increasing agricultural use of 2,4-D and population biomarkers of exposure: findings from the National Health and Nutrition Examination Survey, 2001–2014

Variable

Frequency

(%)

Population

Estimate

High Urine

2,4-D

in Sample

Estimated Population with High Exposure

% with

High 2,4-D

(95% CI)

Unadjusted Odds Ratio (95% CI)

Total

14,395

244,607,215

4681

82,642,980

33.8 (32.1, 35.5)

 

Survey Cycle

 2001–2002

2685 (15.1)

37,004,806

457

6,332,340

17.1 (13.9, 20.3)

ref

 2003–2004

2347 (16.4)

40,112,380

855

14,269,430

35.6 (30.4, 40.8)

2.67 (1.99, 3.70)

 2007–2008

2311 (16.4)

40,153,846

898

15,427,421

38.4 (35.3, 41.5)

3.02 (2.32, 3.94)

 2009–2010

2450 (16.9)

41,228,734

823

14,582,297

35.4 (30.8, 40.0)

2.65 (1.95, 3.61)

 2011–2012

2146 (17.3)

42,213,815

791

16,716,965

39.6 (36.8, 42.4)

3.17 (2.45, 4.11)

 2013–2014

2456 (17.9)

43,893,633

857

15,314,527

34.9 (30.0, 39.8)

2.60 (1.89, 3.56)

Sex

 Male

7099 (49.0)

119,753,832

2614

46,199,838

38.6 (36.5, 40.7)

1.521 (1.39, 1.67)

 Female

7296 (51.0)

124,853,382

2067

36,443,142

29.2 (27.3, 31.1)

ref

Race/Ethnicity

 Non-Hispanic White

5922 (67.1)

164,017,859

2068

58,251,760

35.5 (33.3, 37.7)

ref

 Non-Hispanic Black

3313 (11.7)

28,583,574

1046

601,943

31.3 (28.8, 33.8)

0.83 (0.72, 0.95)

 Mexican American

2850 (9.0)

21,996,531

887

7,054,921

32.1 (29.0, 35.2)

0.86 (0.73, 1.01)

 Other

2310 (12.3)

30,009,251

680

8,389,887

28.0 (25.1, 30.9)

0.70 (0.60, 0.83)

Age (years)

 6–11

2288 (9.2)

22,586,413

874

9,571,185

42.4 (38.8, 46.0)

1.60 (1.40, 1.83)

 12–19

2846 (12.1)

29,636,700

914

10,290,245

34.7 (31.5, 37.9)

1.16 (1.01, 1.33)

 20–59

6243 (60.0)

146,678,123

1875

46,214,496

31.5 (29.7, 33.3)

ref

 60+

3018 (18.7)

45,705,978

1018

16,567,054

36.2 (33.7, 38.7)

1.24 (1.11, 1.37)

Education

 Grade 8 or Less

4569 (18.9)

46,298,948

1585

17,680,657

38.2 (35.5, 40.9)

1.34 (1.16, 1.55)

 Grade 9–12

2615 (14.4)

35,342,844

799

10,865,543

30.7 (28.4, 33.0)

0.96 (0.84, 1.11)

 High School Graduate

2272 (18.3)

44,797,645

676

14,125,909

31.5 (28.5, 34.5)

ref

 Any College

4939 (48.3)

118,167,779

1621

39,970,871

33.8 (31.8, 35.8)

1.11 (0.97, 1.27)

Poverty Income Ratio

 Up to 100%

3638 (16.6)

40,513,665

1082

12,330,209

30.4 (28.3, 32.5)

0.79 (0.71, 0.89)

 100–200%

3898 (21.5)

52,546,663

1228

16,365,202

31.1 (28.8, 33.4)

0.82 (0.73, 0.91)

 Over 200%

6859 (62.0)

151,546,887

2371

53,947,570

35.6 (33.6, 37.6)

ref

Agricultural Worker

 No

14,256 (98.9)

242,014,960

4620

81,271,238

33.6 (31.9, 35.3)

ref

 Yes

139 (1.1)

2,592,255

61

1,371,742

52.9 (46.3, 59.5)

2.23 (1.33, 3.73)

Smoking Status

 No

11,444 (76.3)

186,588,955

3869

66,274,113

35.5 (33.7, 37.3)

ref

 Yes

2951 (23.7)

58,018,260

812

16,368,867

28.2 (25.6, 30.8)

0.71 (0.63, 0.81)

Season

 May 1–October 31

7469 (59.0)

100,371,111

2446

50,441,699

35.0 (32.5, 37.5)

1.14 (0.97, 1.33)

 November 1–April 30

6926 (41.0)

144,236,103

2235

32,201,281

32.1 (30.9, 33.3)

ref

Water Source

 Water Company

8646 (84.6)

132,271,816

2669

42,110,899

31.8 (29.6, 34.0)

1.04 (0.87, 1.24)

 Well

1020 (15.4)

24,127,699

315

7,487,755

31.0 (27.3, 34.7)

ref