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Table 1 Summary of neonicotinoids and neonicotinoid metabolites in cerebro-spinal fluid, plasma and urine of 14 children with haematological cancers

From: Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine

  Cerebro-spinal fluid Plasma Urinea
Number samples Min conc. (ng/mL) Max conc. (ng/mL) Median conc. (ng/mL, of >LOQ) Number samples Min conc. (ng/mL) Max conc. (ng/mL) Median conc. (ng/mL, of >LOQ) Number samples Min conc. (ng/mL) Max conc. (ng/mL) Median conc. (ng/mL, of >LOQ)
< LOD LOD < x < LOQ > LOQ < LOD LOD < x < LOQ > LOQ < LOD LOD < x < LOQ > LOQ
Thiamethoxam 8 (57%) 3 (21%) 3 (21%) < LOD 0.0765 0.0196 6 (43%) 1 (7%) 7 (50%) < LOD 0.4072 0.0203 14 (100%) 0 0 < LOD < LOD < LOD
Clothianidin 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Imidacloprid 12 (86%) 1 (7%) 1 (7%) < LOD 0.0153 0.0153 7 (50%) 6 (43%) 1 (7%) < LOD 0.0216 0.0216 12 (86%) 1 (7%) 1 (/%) < LOD 0.1208 0.1208
Acetamiprid 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Thiacloprid 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Flupyradifurone 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Sulfoxaflor 7 (50%) 3 (21%) 4 (29%) < LOD 0.0124 0.0053 6 (43%) 3 (21%) 5 (36%) < LOD 0.0031 0.0015 10 (71%) 4 (29%) 0 < LOD <LOQ < LOD
Dinotefuran) 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Nitempyram 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
N-desmethyl-acetamiprid 0 1 (7%) 13 (93%) <LOQ 0.1068 0.0130 1 (7%) 1 (/%) 12 (86%) < LOD 0.1812 0.0215 1 (7%) 0 13 (93%) < LOD 6.2753 0.3235
Desnitro-Imidacloprid 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
Imidacloprid-olefin 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 11 (79%) 1 (7%) 2 (14%) < LOD 0.2357 0.2331
6-Chloronicotinic acid 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD 14 (100%) 0 0 < LOD < LOD < LOD
  1. LOD limit of detection, LOQ limit of quantification; aCorrected for specific gravity