Table 1 Summary of neonicotinoids and neonicotinoid metabolites in cerebro-spinal fluid, plasma and urine of 14 children with haematological cancers
From: Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine
Cerebro-spinal fluid | Plasma | Urinea | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number samples | Min conc. (ng/mL) | Max conc. (ng/mL) | Median conc. (ng/mL, of >LOQ) | Number samples | Min conc. (ng/mL) | Max conc. (ng/mL) | Median conc. (ng/mL, of >LOQ) | Number samples | Min conc. (ng/mL) | Max conc. (ng/mL) | Median conc. (ng/mL, of >LOQ) | |||||||
< LOD | LOD < x < LOQ | > LOQ | < LOD | LOD < x < LOQ | > LOQ | < LOD | LOD < x < LOQ | > LOQ | ||||||||||
Thiamethoxam | 8 (57%) | 3 (21%) | 3 (21%) | < LOD | 0.0765 | 0.0196 | 6 (43%) | 1 (7%) | 7 (50%) | < LOD | 0.4072 | 0.0203 | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Clothianidin | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Imidacloprid | 12 (86%) | 1 (7%) | 1 (7%) | < LOD | 0.0153 | 0.0153 | 7 (50%) | 6 (43%) | 1 (7%) | < LOD | 0.0216 | 0.0216 | 12 (86%) | 1 (7%) | 1 (/%) | < LOD | 0.1208 | 0.1208 |
Acetamiprid | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Thiacloprid | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Flupyradifurone | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Sulfoxaflor | 7 (50%) | 3 (21%) | 4 (29%) | < LOD | 0.0124 | 0.0053 | 6 (43%) | 3 (21%) | 5 (36%) | < LOD | 0.0031 | 0.0015 | 10 (71%) | 4 (29%) | 0 | < LOD | <LOQ | < LOD |
Dinotefuran) | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Nitempyram | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
N-desmethyl-acetamiprid | 0 | 1 (7%) | 13 (93%) | <LOQ | 0.1068 | 0.0130 | 1 (7%) | 1 (/%) | 12 (86%) | < LOD | 0.1812 | 0.0215 | 1 (7%) | 0 | 13 (93%) | < LOD | 6.2753 | 0.3235 |
Desnitro-Imidacloprid | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |
Imidacloprid-olefin | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 11 (79%) | 1 (7%) | 2 (14%) | < LOD | 0.2357 | 0.2331 |
6-Chloronicotinic acid | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD | 14 (100%) | 0 | 0 | < LOD | < LOD | < LOD |