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Table 3 Associations between adherence to PCA components and all breast cancer, ER + breast cancer and ER- breast cancer risk. Components are used in continuous and in quintiles in logistic regression models. Odds Ratio (OR) and 95% Confidence Intervals (CI) are presented

From: Application of two statistical approaches (Bayesian Kernel Machine Regression and Principal Component Regression) to assess breast cancer risk in association to exposure to mixtures of brominated flame retardants and per- and polyfluorinated alkylated substances in the E3N cohort

 

All breast cancer

ER + breast cancer

ER- breast cancer

 

Number (%)—Control

Number (%)—Cases

OR [95% CI]

p-value

Number (%)—Control

Number (%)—Cases

OR [95% CI]

p-value

Number (%)—Control

Number (%)—Cases

OR [95% CI]

p-value

 

N = 194

N = 194

  

N = 194

N = 132

  

N = 194

N = 26

  

Component 1, continuous

194 (100.00)

194 (100.00)

1.01 [0.82; 1.25]

0.9208

194 (100.00)

132 (100.00)

1.03 [0.81; 1.31]

0.8068

194 (100.00)

26 (100.00)

0.74 [0.41; 1.33]

0.3169

Component 1, quintiles

   

0.2800

   

0.5932

   

0.0566

 Quintile 1

45 (23.20)

32 (16.49)

Reference

 

45 (23.20)

26 (19.70)

Reference

 

45 (23.20)

3 (11.54)

Reference

 

 Quintile 2

33 (17.01)

45 (23.20)

2.24 [1.09; 4.60]

 

33 (17.01)

29 (21.97)

1.55 [0.70; 3.44]

 

33 (17.01)

7 (26.92)

5.90 [0.83; 41.99]

 

 Quintile 3

40 (20.62)

38 (19.59)

1.55 [0.75; 3.20]

 

40 (20.62)

22 (16.67)

1.12 [0.50; 2.52]

 

40 (20.62)

8 (30.77)

4.57 [0.71; 29.61]

 

 Quintile 4

40 (20.62)

38 (19.59)

1.38 [0.67; 2.84]

 

40 (20.62)

22 (16.67)

1.05 [0.46; 2.35]

 

40 (20.62)

7 (26.92)

3.43 [0.55; 21.20]

 

 Quintile 5

36 (18.56)

41 (21.13)

1.65 [0.80; 3.40]

 

36 (18.56)

33 (25.00)

1.86 [0.86; 4.03]

 

36 (18.56)

1 (3.85)

0.11 [0.01; 2.31]

 

Component 2, continuous

194 (100.00)

194 (100.00)

0.97 [0.78; 1.21]

0.8043

194 (100.00)

132 (100.00)

1.04 [0.81; 1.34]

0.7578

194 (100.00)

26 (100.00)

1.31 [0.77; 2.23]

0.3136

Component 2, quintiles

   

0.6753

   

0.7218

   

0.3073

 Quintile 1

38 (19.59)

39 (20.10)

Reference

 

38 (19.59)

24 (18.18)

Reference

 

38 (19.59)

1 (3.85)

Reference

 

 Quintile 2

43 (22.16)

35 (18.04)

0.76 [0.38; 1.54]

 

43 (22.16)

22 (16.67)

0.80 [0.35; 1.81]

 

43 (22.16)

7 (26.92)

10.46 [0.85; 128.74]

 

 Quintile 3

35 (18.04)

43 (22.16)

0.93 [0.46; 1.89]

 

35 (18.04)

31 (23.48)

1.13 [0.51; 2.51]

 

35 (18.04)

6 (23.08)

4.45 [0.37; 53.96]

 

 Quintile 4

37 (19.07)

41 (21.13)

1.07 [0.53; 2.17]

 

37 (19.07)

29 (21.97)

1.22 [0.55; 2.72]

 

37 (19.07)

7 (26.92)

8.31 [0.69;100.26]

 

 Quintile 5

41 (21.13)

36 (18.56)

0.66 [0.31; 1.39]

 

41 (21.13)

26 (19.70)

0.91 [0.39; 2.13]

 

41 (21.13)

5 (19.23)

3.24 [0.22; 46.87]

 

Component 3, continuous

194 (100.00)

194 (100.00)

1.09 [0.88; 1.36]

0.4141

194 (100.00)

132 (100.00)

1.19 [0.93; 1.51]

0.1702

194 (100.00)

26 (100.00)

1.20 [0.76; 1.88]

0.4374

Component 3, quintiles

   

0.0882

   

0.0397

   

0.5452

 Quintile 1

45 (23.20)

32 (16.49)

Reference

 

45 (23.20)

18 (13.64)

Reference

 

45 (23.20)

6 (23.08)

Reference

 

 Quintile 2

39 (20.10)

39 (20.10)

1.33 [0.66; 2.66]

 

39 (20.10)

23 (17.42)

1.40 [0.61; 3.24]

 

39 (20.10)

4 (15.38)

1.03 [0.18; 6.04]

 

 Quintile 3

37 (19.07)

41 (21.13)

1.72 [0.86; 3.48]

 

37 (19.07)

33 (25.00)

2.61 [1.16; 5.88]

 

37 (19.07)

4 (15.38)

1.88 [0.34; 10.58]

 

 Quintile 4

29 (14.95)

49 (25.26)

2.47 [1.21; 5.06]

 

29 (14.95)

34 (25.76)

3.06 [1.36; 6.89]

 

29 (14.95)

7 (26.92)

3.18 [0.66; 15.45]

 

 Quintile 5

44 (22.68)

33 (17.01)

1.09 [0.54; 2.21]

 

44 (22.68)

24 (18.18)

1.59 [0.70; 3.61]

 

44 (22.68)

5 (19.23)

0.97 [0.18; 5.18]

 

Component 4, continuous

194 (100.00)

194 (100.00)

0.93 [0.74; 1.18]

0.5660

194 (100.00)

132 (100.00)

0.91 [0.70; 1.19]

0.4861

194 (100.00)

26 (100.00)

0.71 [0.41; 1.23]

0.2170

Component 4, quintiles

   

0.1077

   

0.0531

   

0.6901

 Quintile 1

39 (20.10)

38 (19.59)

Reference

 

39 (20.10)

25 (18.94)

Reference

 

39 (20.10)

6 (23.08)

Reference

 

 Quintile 2

39 (20.10)

39 (20.10)

1.26 [0.62; 2.53]

 

39 (20.10)

26 (19.70)

1.15 [0.51; 2.56]

 

39 (20.10)

6 (23.08)

1.41 [0.27; 7.52]

 

 Quintile 3

30 (15.46)

48 (24.74)

1.94 [0.93; 4.03]

 

30 (15.46)

37 (28.03)

2.14 [0.94; 4.89]

 

30 (15.46)

6 (23.08)

1.37 [0.23; 8.13]

 

 Quintile 4

43 (22.16)

35 (18.04)

0.89 [0.43; 1.83]

 

43 (22.16)

22 (16.67)

0.80 [0.34; 1.85]

 

43 (22.16)

5 (19.23)

0.65 [0.10; 4.12]

 

 Quintile 5

43 (22.16)

34 (17.53)

0.79 [0.37; 1.65]

 

43 (22.16)

22 (16.67)

0.69 [0.29; 1.66]

 

43 (22.16)

3 (11.54)

0.45 [0.07; 2.79]

 
  1. All models are adjusted on age at blood draw (continuous), body mass index at blood draw (kg/m2, continuous), year of blood draw (continuous), total plasma lipid content (ng/L, continuous), smoking status (never vs. ever), physical activity measured in metabolic equivalent tasks (MET)-hour/week (continuous), education (≤ 12 years, 12 to 14 years, > 14 years), personal history of benign breast disease (no vs. yes), and family history of breast cancer (none, in first-degree relatives, in extended relatives), parity and age at first fullterm pregnancy (FFTP) (no children, 1 or 2 children and < 30 years old at FFTP, ≥ 3 children and < 30 years old at FFTP, ≥ 30 years old at FFTP), total breastfeeding duration (never, ≤ 6 or > 6 months), age at menarche years, continuous), current use of menopausal hormone therapy (yes, no), use of oral contraceptives (ever vs. never), menopausal status and age at menopause (menopause before age 51, menopause at age 51 or later)
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Environmental Health

ISSN: 1476-069X