Prenatal and childhood exposure to chlordecone and adiposity of seven-year-old children in the Timoun mother–child cohort study in Guadeloupe (French West Indies)

Table 4 Association between chlordecone concentrations and adiposity at seven years of age

		Model 1^b	Model 2^c	Model 3^d
Chlordecone in blood at 7 years (µg/L)	N	β (95% CI)	β (95% CI)	β (95% CI)
Boys	221/283^a
< 0.017	53	0 (ref)	0 (ref)	0 (ref)
0.017—0.051	51	0.20 (-0.35; 0.74)	0.12 (-0.36; 0.60)	0.16 (-0.39; 0.70)
0.051—0.112	62	-0.22 (-0.73; 0.30)	-0.48 (-0.95; -0.01)	-0.16 (-0.68; 0.36)
≥ 0.112	55	-0.07 (-0.61; 0.46)	-0.10 (-0.58; 0.38)	-0.01 (-0.56; 0.53)
log₁₀	221	-0.07 (-0,.42; 0.28)	-0,09 (-0.38; 0.20)	-0.08 (-0.43; 0.27)
Girls	225/292^a
< 0.017	60	0 (ref)	0 (ref)	0 (ref)
0.017—0.051	59	0.20 (-0.23; 0.62)	0.28 (-0.12; 0.69)	0.32 (-0.13; 0.77)
0.051—0.112	49	0.06 (-0.40; 0.51)	0.01 (-0.41; 0.44)	0.01 (-0.45; 0.47)
≥ 0.112	57	-0.10 (-0.54; 0.33)	-0.12 (-0.54; 0.30)	0.01 (-0.44; 0.46)
log₁₀	225	-0.001 (-0.29; 0.29)	-0,07 (-0.36; 0.22)	0.01 (-0.28; 0.30)

Adiposity is a latent variable defined from the BMI z-score, % Fat Mass, Sum of subscapular and tricipital folds, and Waist-to-Height Ratio, expressed in the same units as the BMI z-scores
Indices of fit (Model 1, exposure in quartiles):
Boys: χ² p = 0.02; RMSEA = 0.04 95% CI, 0.02–0.05; CFI = 0.98; GFI = 1; SRMR = 0.01
Girls: χ² p = 0.06; RMSEA = 0.03 95% CI, 0.00–0.05; CFI = 0.99; GFI = 1; SRMR = 0.01
^aMissing blood concentrations at seven years of age accounted for by the FIML estimation
^bModel 1 was adjusted for: exact age at measurement (months), maternal place of birth (Guadeloupe / Martinique, other Caribbean Islands, Europe), maternal BMI before pregnancy (< 18.5, 18.5 to < 25, 25 to < 30, ≥ 30 kg/m²), maternal level of education (< 5, 5 to < 12, ≥ 12 years), duration of breastfeeding (four categories), time spent exercising per week, time spent watching TV or playing videogames per week, obesogenic dietary habits at seven years of age (four categories), blood total lipids at 7 years of age (g/L, log₁₀ scale)
^cModel 2 is the same as Model 1 but additionally adjusted for blood concentrations of PCB153 and pp’-DDE
^dModel 3 is the same as Model 1 but additionally adjusted for cord blood concentrations of chlordecone (N = 131 boys and N = 158 girls with blood samples available at birth (cord blood) and at 7 years)

ISSN: 1476-069X