Skip to main content

Table 3 Direct and indirect effects of WQS scores on impaired eGFR risk with the levels of plasma folate and uric acid as the mediators

From: Association and mediation analyses among multiple metals exposure, plasma folate, and community-based impaired estimated glomerular filtration rate in central Taiwan

  

Case/control number

OR (95%CI)

 

WQS scores

Plasma folate

  

< 1.41

≥ 6

56/546

1.00&

< 1.41

< 6

25/163

1.51 (0.76, 3.01)

≥ 1.41

≥ 6

102/570

2.01 (1.28, 3.17) **

≥ 1.41

< 6

42/139

2.83 (1.55, 5.17) ***

   

trend p = 0.0002

   

multiplicative interaction p = 0.8664

   

RERI (95% CI) = 0.35 (−0.82, 1.52)

WQS scores

Uric acid

   

< 1.41

< 7

63/640

1.00

< 1.41

> = 7

17/64

2.17 (1.12, 4.22) *

≥1.41

< 7

85/591

1.35 (0.93, 1.96)

≥1.41

> = 7

59/113

4.16 (2.63, 6.58) ***

   

trend p < 0.0001

   

multiplicative interaction p = 0.3824

   

RERI (95% CI) = 1.64 (−0.36, 3.64)

Mediator:

 

NDE (95%CI)

NIE (95%CI)

PM (%) (95%CI)

Plasma folate

 

1.65 (1.29, 2.01) ***

1.00 (0.99, 1.01)

−0.21 (−1.31, 0.88)

Uric acid

 

1.51 (1.18, 1.85) **

1.11 (1.06, 1.16) ***

24.07 (11.69, 36.45) ***

  1. RERI relative excess risk due to interaction, NDE Natural direct effect, NIE Natural indirect effect, PM Estimated proportion mediated
  2. All models adjusted for age, sex, BMI (category), diabetes, and hypertension. #0.05 < p < 0.1; * 0.01 < p < 0.05; ** 0.001 < p < 0.01; *** p < 0.001