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Table 5 Cox models for associations between dietary pesticide exposure and Type 2 diabetes, NutriNet-Santé Study, France, 2014 (N = 33,013)

From: Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

 

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

Total

P-value for trend

Number of participants

6602

6603

6603

6603

6602

33,013

 

NMF Component 1

  Incident Cases

52

83

77

72

56

340

 

  Person-years

33,331.09

34,305.64

34,129.91

34,229.60

33,908.04

169,904.28

 

  Model 1, HR (95% CI)

1

1.59 (1.13, 2.25)

1.48 (1.04, 2.10)

1.32 (0.92, 1.88)

1.05 (0.72, 1.54)

 

0.74

  Model 2, HR (95% CI)

1

1.37 (0.96, 1.94)

1.51 (1.06, 2.15)

1.44 (1.00, 2.07)

1.40 (0.95, 2.06)

 

0.10

  Model 3, HR (95% CI)

1

1.36 (0.96, 1.93)

1.53 (1.07, 2.18)

1.48 (1.03, 2.12)

1.47 (1.00, 2.18)

 

0.048

NMF Component 2

  Incident Cases

59

70

73

73

65

340

 

  Person-years

33,476.37

33,815.55

34,159.62

34,349.49

34,103.25

169,904.28

 

  Model 1, HR (95% CI)

1

1.13 (0.80, 1.60)

1.07 (0.76, 1.51)

1.00 (0.71, 1.41)

0.88 (0.62, 1.26)

 

0.33

  Model 2, HR (95% CI)

1

1.07 (0.75, 1.51)

1.10 (0.78, 1.57)

1.14 (0.80, 1.63)

1.06 (0.73, 1.56)

 

0.66

  Model 3, HR (95% CI)

1

1.01 (0.71, 1.43)

1.07 (0.75, 1.52)

1.12 (0.79, 1.61)

1.11 (0.76, 1.62)

 

0.46

NMF Component 3

  Incident Cases

95

76

67

59

43

340

 

  Person-years

33,492.56

33,875.27

34,051.61

34,183.11

34,301.73

169,904.28

 

  Model 1, HR (95% CI)

1

0.90 (0.61, 1.33)

0.83 (0.61, 1.12)

0.66 (0.49, 0.88)

0.45 (0.31, 0.64)

 

 < .0001

  Model 2, HR (95% CI)

1

0.89 (0.60, 1.31)

1.01 (0.75, 1.37)

0.94 (0.69, 1.27)

0.79 (0.54, 1.16)

 

0.36

  Model 3, HR (95% CI)

1

0.95 (0.70, 1.29)

1.06 (0.77, 1.46)

1.00 (0.71, 1.41)

0.88 (0.60, 1.29)

 

0.73

NMF Component 4

  Incident Cases

103

76

70

53

38

340

 

  Person-years

33,655.47

33,739.32

33,877.51

34,142.43

34,489.55

169,904.28

 

  Model 1, HR (95% CI)

1

0.89 (0.60, 1.31)

0.83 (0.62, 1.12)

0.79 (0.58, 1.08)

0.52 (0.38, 0.73)

 

 < .0001

  Model 2, HR (95% CI)

1

1.02 (0.69, 1.51)

0.99 (0.73, 1.34)

1.01 (0.73, 1.38)

0.79 (0.57, 1.11)

 

0.16

  Model 3, HR (95% CI)

1

1.02 (0.76, 1.38)

1.13 (0.83, 1.54)

0.86 (0.61, 1.21)

0.80 (0.54, 1.18)

 

0.24

  1. NMF Non-Negative Matrix Factorization, HR Hazard Ratio, 95% CI 95% Confidence Interval. // Median follow-up = 5.95 years
  2. Model 1 adjusted for age (time-scale), gender. / Model 2 adjusted for age (time-scale), gender, physical activity (IPAQ), smoking status, educational level, occupation, monthly income per household unit, marital status, alcohol-free energy intake, family history of diabetes, weight, height. / Model 3 adjusted for model 2 + sPNNS-GS2 score
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Environmental Health

ISSN: 1476-069X