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Table 5 Cox models for associations between dietary pesticide exposure and Type 2 diabetes, NutriNet-Santé Study, France, 2014 (N = 33,013)

From: Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

  Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 Total P-value for trend
Number of participants 6602 6603 6603 6603 6602 33,013  
NMF Component 1
  Incident Cases 52 83 77 72 56 340  
  Person-years 33,331.09 34,305.64 34,129.91 34,229.60 33,908.04 169,904.28  
  Model 1, HR (95% CI) 1 1.59 (1.13, 2.25) 1.48 (1.04, 2.10) 1.32 (0.92, 1.88) 1.05 (0.72, 1.54)   0.74
  Model 2, HR (95% CI) 1 1.37 (0.96, 1.94) 1.51 (1.06, 2.15) 1.44 (1.00, 2.07) 1.40 (0.95, 2.06)   0.10
  Model 3, HR (95% CI) 1 1.36 (0.96, 1.93) 1.53 (1.07, 2.18) 1.48 (1.03, 2.12) 1.47 (1.00, 2.18)   0.048
NMF Component 2
  Incident Cases 59 70 73 73 65 340  
  Person-years 33,476.37 33,815.55 34,159.62 34,349.49 34,103.25 169,904.28  
  Model 1, HR (95% CI) 1 1.13 (0.80, 1.60) 1.07 (0.76, 1.51) 1.00 (0.71, 1.41) 0.88 (0.62, 1.26)   0.33
  Model 2, HR (95% CI) 1 1.07 (0.75, 1.51) 1.10 (0.78, 1.57) 1.14 (0.80, 1.63) 1.06 (0.73, 1.56)   0.66
  Model 3, HR (95% CI) 1 1.01 (0.71, 1.43) 1.07 (0.75, 1.52) 1.12 (0.79, 1.61) 1.11 (0.76, 1.62)   0.46
NMF Component 3
  Incident Cases 95 76 67 59 43 340  
  Person-years 33,492.56 33,875.27 34,051.61 34,183.11 34,301.73 169,904.28  
  Model 1, HR (95% CI) 1 0.90 (0.61, 1.33) 0.83 (0.61, 1.12) 0.66 (0.49, 0.88) 0.45 (0.31, 0.64)    < .0001
  Model 2, HR (95% CI) 1 0.89 (0.60, 1.31) 1.01 (0.75, 1.37) 0.94 (0.69, 1.27) 0.79 (0.54, 1.16)   0.36
  Model 3, HR (95% CI) 1 0.95 (0.70, 1.29) 1.06 (0.77, 1.46) 1.00 (0.71, 1.41) 0.88 (0.60, 1.29)   0.73
NMF Component 4
  Incident Cases 103 76 70 53 38 340  
  Person-years 33,655.47 33,739.32 33,877.51 34,142.43 34,489.55 169,904.28  
  Model 1, HR (95% CI) 1 0.89 (0.60, 1.31) 0.83 (0.62, 1.12) 0.79 (0.58, 1.08) 0.52 (0.38, 0.73)    < .0001
  Model 2, HR (95% CI) 1 1.02 (0.69, 1.51) 0.99 (0.73, 1.34) 1.01 (0.73, 1.38) 0.79 (0.57, 1.11)   0.16
  Model 3, HR (95% CI) 1 1.02 (0.76, 1.38) 1.13 (0.83, 1.54) 0.86 (0.61, 1.21) 0.80 (0.54, 1.18)   0.24
  1. NMF Non-Negative Matrix Factorization, HR Hazard Ratio, 95% CI 95% Confidence Interval. // Median follow-up = 5.95 years
  2. Model 1 adjusted for age (time-scale), gender. / Model 2 adjusted for age (time-scale), gender, physical activity (IPAQ), smoking status, educational level, occupation, monthly income per household unit, marital status, alcohol-free energy intake, family history of diabetes, weight, height. / Model 3 adjusted for model 2 + sPNNS-GS2 score