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Table 7 Sensitivity analyses for associations between dietary pesticide exposure and Type 2 Diabetes risk, NutriNet-Santé Study, France, 2014 (N = 33,013)

From: Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

  Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 P-value for trend
Excluding Early T2D Cases (within 1 year of baseline), N = 32,967, 294 T2D cases
  NMF Component 1 1 1.35 (0.93, 1.97) 1.35 (0.92, 1.99) 1.44 (0.98, 2.12) 1.50 (0.99, 2.27) 0.06
  NMF Component 2 1 1.05 (0.72, 1.52) 0.99 (0.68, 1.45) 1.03 (0.70, 1.52) 1.19 (0.79, 1.77) 0.49
  NMF Component 3 1 1.06 (0.70, 1.60) 1.18 (0.85, 1.64) 1.01 (0.73, 1.41) 0.90 (0.59, 1.37) 0.78
  NMF Component 4 1 1.09 (0.71, 1.66) 1.10 (0.79, 1.53) 1.16 (0.83, 1.63) 0.83 (0.58, 1.20) 0.51
Excluding CVDa cases before or during follow-up, N = 32,773, 235 T2D cases
  NMF Component 1 1 1.34 (0.94, 1.91) 1.55 (1.09, 2.22) 1.50 (1.04, 2.16) 1.47 (0.99, 2.18) 0.04
  NMF Component 2 1 0.97 (0.68, 1.39) 1.06 (0.75, 1.51) 1.15 (0.80, 1.65) 1.11 (0.76, 1.63) 0.39
  NMF Component 3 1 0.91 (0.61, 1.35) 1.07 (0.79, 1.46) 1.02 (0.75, 1.38) 0.87 (0.59, 1.29) 0.79
  NMF Component 4 1 1.04 (0.70, 1.54) 0.99 (0.73, 1.35) 1.06 (0.77, 1.45) 0.83 (0.59, 1.16) 0.27
Excluding metabolic abnormalitiesb at baseline, N = 24,962, 129 T2D cases
  NMF Component 1 1 1.41 (0.75, 2.64) 2.17 (1.19, 3.95) 1.82 (0.98, 3.39) 1.81 (0.93, 3.52) 0.05
  NMF Component 2 1 0.65 (0.36, 1.18) 0.87 (0.50, 1.54) 1.12 (0.65, 1.94) 1.17 (0.66, 2.07) 0.22
  NMF Component 3 1 1.18 (0.65, 2.14) 0.95 (0.56, 1.61) 0.97 (0.58, 1.63) 1.11 (0.61, 2.01) 0.86
  NMF Component 4 1 1.23 (0.66, 2.30) 1.57 (0.95, 2.59) 1.14 (0.66, 1.98) 1.20 (0.69, 2.07) 0.74
  1. All models were adjusted for age (time-scale), gender, physical activity (IPAQ), smoking status, educational level, monthly income per household unit, marital status, alcohol-free energy intake, family history of diabetes, weight, height, sPNNS-GS2 score
  2. aParticipants developing a cardiovascular disease during the follow-up or before were excluded from the sample
  3. bParticipants with hypertension or dyslipidaemia at baseline were removed
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Environmental Health

ISSN: 1476-069X