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Table 7 Sensitivity analyses for associations between dietary pesticide exposure and Type 2 Diabetes risk, NutriNet-Santé Study, France, 2014 (N = 33,013)

From: Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

 

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P-value for trend

Excluding Early T2D Cases (within 1 year of baseline), N = 32,967, 294 T2D cases

  NMF Component 1

1

1.35 (0.93, 1.97)

1.35 (0.92, 1.99)

1.44 (0.98, 2.12)

1.50 (0.99, 2.27)

0.06

  NMF Component 2

1

1.05 (0.72, 1.52)

0.99 (0.68, 1.45)

1.03 (0.70, 1.52)

1.19 (0.79, 1.77)

0.49

  NMF Component 3

1

1.06 (0.70, 1.60)

1.18 (0.85, 1.64)

1.01 (0.73, 1.41)

0.90 (0.59, 1.37)

0.78

  NMF Component 4

1

1.09 (0.71, 1.66)

1.10 (0.79, 1.53)

1.16 (0.83, 1.63)

0.83 (0.58, 1.20)

0.51

Excluding CVDa cases before or during follow-up, N = 32,773, 235 T2D cases

  NMF Component 1

1

1.34 (0.94, 1.91)

1.55 (1.09, 2.22)

1.50 (1.04, 2.16)

1.47 (0.99, 2.18)

0.04

  NMF Component 2

1

0.97 (0.68, 1.39)

1.06 (0.75, 1.51)

1.15 (0.80, 1.65)

1.11 (0.76, 1.63)

0.39

  NMF Component 3

1

0.91 (0.61, 1.35)

1.07 (0.79, 1.46)

1.02 (0.75, 1.38)

0.87 (0.59, 1.29)

0.79

  NMF Component 4

1

1.04 (0.70, 1.54)

0.99 (0.73, 1.35)

1.06 (0.77, 1.45)

0.83 (0.59, 1.16)

0.27

Excluding metabolic abnormalitiesb at baseline, N = 24,962, 129 T2D cases

  NMF Component 1

1

1.41 (0.75, 2.64)

2.17 (1.19, 3.95)

1.82 (0.98, 3.39)

1.81 (0.93, 3.52)

0.05

  NMF Component 2

1

0.65 (0.36, 1.18)

0.87 (0.50, 1.54)

1.12 (0.65, 1.94)

1.17 (0.66, 2.07)

0.22

  NMF Component 3

1

1.18 (0.65, 2.14)

0.95 (0.56, 1.61)

0.97 (0.58, 1.63)

1.11 (0.61, 2.01)

0.86

  NMF Component 4

1

1.23 (0.66, 2.30)

1.57 (0.95, 2.59)

1.14 (0.66, 1.98)

1.20 (0.69, 2.07)

0.74

  1. All models were adjusted for age (time-scale), gender, physical activity (IPAQ), smoking status, educational level, monthly income per household unit, marital status, alcohol-free energy intake, family history of diabetes, weight, height, sPNNS-GS2 score
  2. aParticipants developing a cardiovascular disease during the follow-up or before were excluded from the sample
  3. bParticipants with hypertension or dyslipidaemia at baseline were removed