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Table 3 Number of cases and controls, odds ratio (OR) and 95% confidence interval (CI) by exposure (ever vs never) and cumulative exposure from SYN-JEM, unlagged and at lag 10, 20 and 30 years, men and women – the MISEM study, 2012–2015, Italy

From: Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM)

 

Lag 0

Lag 10

Lag 20

Lag 30

SYN-JEM exposure

Cases

Ctrls

ORa

CI

ORa

CI

ORa

CI

ORa

CI

Ever/never

 Unexposed

278

446

1.00

(ref)

1.00

(ref)

1.00

(ref)

1.00

(ref)

 Exposed

333

262

2.22

(1.70–2.91)

2.21

(1.69–2.90)

2.29

(1.74–3.00)

2.15

(1.64–2.82)

 P-Wald test gender interaction

  

0.27

 

0.28

 

0.28

 

0.59

 

 AIC

  

1597.49

 

1595.26

 

1591.05

 

1609.33

 

Below/above median cumulative exposure (in f/mL-y)

 Unexposed

278

446

1.00

(ref)

1.00

(ref)

1.00

(ref)

1.00

(ref)

  < 0.86

120

131

1.71

(1.21–2.42)

1.71

(1.21–2.42)

1.84

(1.30–2.59)

1.74

(1.24–2.46)

  ≥ 0.86

213

131

2.66

(1.95–3.64)

2.65

(1.94–3.61)

2.68

(1.96–3.66)

2.52

(1.84–3.45)

 P-trend

  

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 P-Wald test gender interaction

  

0.46

 

0.48

 

0.47

 

0.76

 

 AIC

  

1593.89

 

1591.87

 

1589.08

 

1607.56

 

Tertiles of cumulative exposure (in f/mL-y)

 Unexposed

278

446

1.00

(ref)

1.00

(ref)

1.00

(ref)

1.00

(ref)

  < 0.34

64

87

1.35

(0.88–2.05)

1.34

(0.88–2.04)

1.45

(0.96–2.21)

1.21

(0.79–1.85)

 0.34–1.62

118

87

2.52

(1.75–3.62)

2.53

(1.76–3.64)

2.59

(1.80–3.73)

2.48

(1.72–3.57)

  > 1.62

151

88

2.65

(1.85–3.77)

2.62

(1.84–3.72)

2.69

(1.88–3.83)

2.64

(1.85–3.77)

 P-trend

  

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 P-Wald test gender interaction

  

0.39

 

0.36

 

0.30

 

0.58

 

 AIC

  

1591.96

 

1589.78

 

1587.16

 

1601.36

 

Cumulative exposure, continuos

 Unexposed

278

446

1.00

(ref)

1.00

(ref)

1.00

(ref)

1.00

(ref)

 Unit exposure: 1 f/mL-y

333

262

1.28

(1.16–1.42)

1.28

(1.16–1.41)

1.28

(1.16–1.42)

1.31

(1.18–1.46)

 AIC

  

1603.43

 

1601.83

 

1600.27

 

1612.64

 

Log-cumulative exposure, continuos

 Unexposed

278

446

1.00

(ref)

1.00

(ref)

1.00

(ref)

1.00

(ref)

 Unit exposure: 1 log(f/mL-y + 1)

333

262

2.06

(1.62–2.61)

2.05

(1.61–2.60)

2.06

(1.62–2.61)

2.12

(1.65–2.72)

 AIC

  

1594.23

 

1592.57

 

1590.98

 

1603.91

 
  1. AIC Akaike information criterion
  2. aOR adjusted by centre, gender, age and type of interview
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Environmental Health

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