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Table 3 Multiple linear regression coefficient (95% CI) for changes in lipid metabolism indicators associated with unit-increases in Ln-phthalate metabolites a

From: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults

Variables

ln-HDL-C

 

ln-LDL-C

 

ln-TC

 

ln-TG

 

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

MMP(ng/mL)

−0.011 (− 0.033, 0.010)

0.303

− 0.036 (− 0.065, − 0.007)

0.014 *

− 0.011 (− 0.030, 0.008)

0.267

0.022 (− 0.029, 0.073)

0.390

MEP(ng/mL)

− 0.015 (− 0.036, 0.006)

0.161

− 0.013 (− 0.040, 0.015)

0.368

−0.022 (− 0.041, − 0.004)

0.016 *

−0.032 (− 0.081, 0.017)

0.200

MiBP(ng/mL)

0.007 (−0.017, 0.031)

0.580

−0.005 (− 0.037, 0.026)

0.744

0.007 (− 0.014, 0.028)

0.510

0.005 (− 0.052, 0.061)

0.874

MnBP(ng/mL)

0.006 (− 0.027, 0.039)

0.714

−0.013 (− 0.056, 0.030)

0.550

− 0.012 (− 0.041, 0.017)

0.417

0.017 (− 0.059, 0.093)

0.656

ΣDBPm (n mole/mL) b

− 0.025 (− 0.085, 0.036)

0.421

0.061 (− 0.017, 0.140)

0.125

0.025 (− 0.027, 0.078)

0.344

− 0.034 (− 0.173, 0.106)

0.635

ΣDEHPm (n mole/mL) b

0.058 (0.008, 0.109)

0.024 *

0.005 (− 0.061, 0.071)

0.889

0.039 (− 0.005, 0.084)

0.085

0.063 (− 0.055, 0.180)

0.293

Variables

ln-CRI-I

 

ln-CRI-II

 

ln-NHC

 

ln-AC

 

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

MMP(ng/mL)

0.001 (−0.023, 0.024)

0.960

−0.024 (− 0.057, 0.008)

0.142

− 0.014 (− 0.040, 0.012)

0.279

−0.002 (− 0.037, 0.031)

0.875

MEP(ng/mL)

−0.008 (− 0.031, 0.015)

0.506

0.002 (− 0.029, 0.034)

0.879

−0.025 (− 0.050, 0.000)

0.048 *

−0.010 (− 0.043, 0.023)

0.549

MiBP(ng/mL)

0.0003 (−0.026, 0.027)

0.981

−0.012 (− 0.048, 0.024)

0.511

0.006 (− 0.023, 0.034)

0.702

−0.001 (− 0.039, 0.036)

0.947

MnBP(ng/mL)

−0.018 (− 0.053, 0.018)

0.319

−0.019 (− 0.068, 0.030)

0.441

−0.019 (− 0.058, 0.019)

0.326

−0.025 (− 0.076, 0.025)

0.327

ΣDBPm (n mole/mL)b

0.050 (−0.015, 0.115)

0.132

0.086 (−0.004, 0.175)

0.060

0.052 (−0.019, 0.123)

0.150

0.076 (−0.017, 0.170)

0.108

ΣDEHPm (n mole/mL)b

−0.019 (− 0.074, 0.036)

0.489

− 0.054 (− 0.129, 0.022)

0.162

0.023 (− 0.037, 0.082)

0.453

−0.036 (− 0.114, 0.043)

0.372

  1. * < 0.05; ** < 0.01
  2. a Adjusted for age, sex, BMI, cigarette smoking, and urinary creatinine levels
  3. bΣDEHPm = sum molar concentrations of MEHP + MEHHP + MEOHP + MECPP + MCMHP; ΣDBPm = sum molar concentrations of MiBP + MnBP