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Table 4 Multiple linear regression coefficient (95% CI) for changes in serum thyroid hormones associated with unit-increases in Ln-phthalate metabolites a

From: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults

Variables

ln-T3

 

ln-T4

 

ln-free T4

 

ln-TSH

 

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

Adjusted β (95%CI)

P value

MMP(ng/mL)

0.006 (−0.010, 0.021)

0.455

0.009 (−0.009, 0.028)

0.329

−0.007 (− 0.024, 0.009)

0.374

−0.012 (− 0.070, 0.045)

0.670

MEP(ng/mL)

0.004 (−0.011, 0.019)

0.576

−0.012 (− 0.029, 0.006)

0.195

0.008 (− 0.008, 0.024)

0.313

0.037 (− 0.019, 0.092)

0.195

MiBP(ng/mL)

0.011 (−0.006, 0.028)

0.195

−0.017 (− 0.037, 0.004)

0.110

0.007 (− 0.011, 0.026)

0.423

0.029 (− 0.035, 0.093)

0.368

MnBP(ng/mL)

0.027 (0.004, 0.050)

0.022 *

−0.026 (− 0.054, 0.001)

0.062

0.044 (0.019, 0.068)

< 0.001 **

0.047 (−0.039, 0.134)

0.280

ΣDBPm (n mole/mL)b

−0.061 (− 0.103, − 0.019)

0.005 **

0.041 (− 0.009, 0.092)

0.107

−0.051 (− 0.095, − 0.006)

0.027 *

−0.085 (− 0.243, 0.073)

0.290

ΣDEHPm (n mole/mL)b

−0.013 (− 0.048, 0.022)

0.466

−0.056 (− 0.098, − 0.013)

0.011 *

−0.021 (− 0.058, 0.017)

0.282

0.010 (− 0.123, 0.143)

0.880

  1. * < 0.05; ** < 0.01
  2. a Adjusted for age, sex, BMI, cigarette smoking, TBG levels, and urinary creatinine levels
  3. bΣDEHPm = sum molar concentrations of MEHP + MEHHP + MEOHP + MECPP + MCMHP; ΣDBPm = sum molar concentrations of MiBP + MnBP