Table 6 Mediation effects of exposure to phthalates on the homeostatic model assessment of estimated lipid metabolism indicators through thyroid hormones a
Exposure and outcome | Mediator | Estimate indirect effect (95% CI) | Estimate direct effect (95% CI) | Estimated proportion mediated |
|---|---|---|---|---|
∑DEHPm and HDL-C | T4 | 0.015 (− 0.0087, 0.05) | 0.025 (− 0.0282, 0.08) | 32.2% |
∑DEHPm and CRI-I | T4 | −0.019 (− 0.0535, 0.01) | 0.001 (− 0.0556, 0.06) | 46.8% |
∑DEHPm and CRI-II | T4 | −0.031 (− 0.0790, 0.00) | −0.042 (− 0.1236, 0.04) | 38.9% |
∑DEHPm and AC | T4 | −0.031 (− 0.0813, 0.01) | −0.008 (− 0.0910, 0.07) | 50.3% |
∑DEHPm and CRI-I | Free T4 | −0.001 (− 0.0150, 0.01) | −0.023 (− 0.0775, 0.03) | 3.7% |
∑DEHPm and AC | Free T4 | −0.001 (− 0.0203, 0.02) | −0.038 (− 0.1156, 0.04) | 2.2% |