Biomarker | Level | Model 1a β (95% CI) | p | Model 2b β (95% CI) | p | Model 3c β (95% CI) | p |
---|---|---|---|---|---|---|---|
% U-iAs | Normal B12 | 2.07 (−22.72, 26.85) | 4.31 (− 20.01, 28.64) | 1.08 (−26.06, 28.22) | |||
B12 deficient | −16.81 (− 42, 8.37) | 0.19 | − 18.27 (− 43.57, 7.03) | 0.15 | − 16.10 (− 43.96, 11.77) | 0.30 | |
Normal homocysteine | −3.12 (− 20.05, 13.81) | − 3.29 (− 20.25, 13.66) | − 2.73 (− 20.69, 15.22) | ||||
Hyperhomocysteinemia | −79.06 (− 196.3, 38.19) | 0.16 | − 81.20 (− 215.70, 53.31) | 0.15 | − 59.58 (− 161.44, 42.27) | 0.31 | |
B12 > median | 1.99 (− 18.07, 22.04) | 3.61 (− 16.06, 23.28) | 0.10 (− 21.56, 21.77) | ||||
B12 < =median | − 22.79 (− 54.67, 9.09) | 0.18 | − 24.60 (− 56.30, 7.11) | 0.15 | −13.66 (− 48.67, 21.35) | 0.47 | |
Folate >median | 0.83 (− 17.05, 18.71) | 0.81 (− 17.25, 18.86) | −1.27 (− 20.05, 17.51) | ||||
Folate <=median | −17.57 (− 53.40, 18.26) | 0.37 | − 17.58 (− 53.55, 18.39) | 0.38 | − 8.90 (− 49.20, 31.40) | 0.71 | |
Homocysteine <median | 2.07 (− 16.33, 20.46) | 1.44 (− 16.93, 19.81) | 3.20 (− 16.47, 22.87) | ||||
Homocysteine > = median | − 27.96 (− 62.33, 6.41) | 0.07 | −31.19 (− 64.67, 2.28) | 0.07 | − 28.63 (− 67.80, 10.54) | 0.12 | |
% U-MMAs | Normal B12 | − 14.57 (− 57.98, 28.85) | − 6.43 (− 49.81, 36.95) | −17.65 (− 68.03, 32.73) | |||
B12 deficient | −28.69 (− 53.97, − 3.42) | 0.47 | − 28.37 (− 53.63, − 3.10) | 0.45 | −24.52 (− 53.14, 4.09) | 0.71 | |
Normal homocysteine | −21.71 (− 44.14, 0.72) | − 21.53 (− 44.08, 1.03) | − 21.91 (− 47.24, 3.42) | ||||
Hyperhomocysteinemia | −63.29 (− 154.77, 28.19) | 0.41 | −90.66 (− 193.61, 12.30) | 0.39 | −35.73 (− 119.84, 48.38) | 0.76 | |
B12 > median | − 10.51 (− 38.16, 17.14) | −5.30 (− 32.72, 22.12) | −11.86 (− 43.30, 19.57) | ||||
B12 < =median | − 46.23 (− 82.26, − 10.19) | 0.12 | − 42.57 (− 78.65, − 6.49) | 0.12 | − 41.54 (− 84.48, 1.40) | 0.22 | |
Folate >median | −18.46 (− 43.09, 6.18) | −17.69 (−42.41, 7.03) | −20.58 (− 47.45, 6.29) | ||||
Folate <=median | −23.45 (− 65.74, 18.84) | 0.88 | −18.87 (− 62.27, 24.53) | 0.94 | − 14.34 (− 65.27, 36.59) | 0.82 | |
Homocysteine <median | −8.40 (− 38.64, 21.84) | −9.69 (− 39.89, 20.52) | −11.77 (− 47.49, 23.94) | ||||
Homocysteine > = median | −33.76 (− 64.90, − 2.61) | 0.21 | − 28.99 (− 59.88, 1.91) | 0.23 | −28.20 (−62.70, 6.29) | 0.51 | |
% U-DMAs | Normal B12 | 1.25 (−15.84, 18.34) | −1.10 (− 18, 15.80) | 1.95 (−17.05, 20.94) | |||
B12 deficient | 15.72 (0.92, 30.52) | 0.12 | 16.11 (1.30, 30.91) | 0.11 | 14.53 (−2.34, 31.41) | 0.23 | |
Normal homocysteine | 6.45 (−4.53, 17.42) | 6.45 (−4.55, 17.45) | 6.04 (−5.92, 18) | ||||
Hyperhomocysteinemia | 47.81 (−9.56, 105.17) | 0.16 | 57.96 (−5.51, 121.43) | 0.15 | 31.83 (−20.20, 83.86) | 0.38 | |
B12 > median | 1.44 (−11.42, 14.31) | −0.37 (−13.05, 12.32) | 2.35 (−11.82, 16.52) | ||||
B12 < =median | 24.85 (4.27, 45.42) | 0.05 | 24.22 (3.80, 44.64) | 0.05 | 20.13 (−4.31, 44.57) | 0.18 | |
Folate >median | 3.59 (−7.90, 15.08) | 3.48 (−8.10, 15.06) | 4.70 (−7.52, 16.92) | ||||
Folate <=median | 15.25 (−8.53, 39.04) | 0.40 | 13.78 (−10.32, 37.89) | 0.42 | 8.91 (−19.51, 37.33) | 0.76 | |
Homocysteine <median | 0.50 (−12.34, 13.34) | 1.04 (−11.79, 13.86) | 0.18 (−13.96, 14.33) | ||||
Homocysteine > = median | 19.8 (1.47, 38.12) | 0.05 | 18.86 (0.95, 36.77) | 0.05 | 18.63 (−2.23, 39.49) | 0.13 | |
C-tAs | Normal B12 | −91.24 (− 1287.92, 1105.43) | −20.88 (− 1195.59, 1153.83) | −304.12 (− 1645.15, 1036.91) | |||
B12 deficient | − 243.29 (−598.57, 111.98) | 0.40 | − 230.77 (− 586.09, 124.55) | 0.38 | − 359.19 (− 932.36, 213.97) | 0.41 | |
Normal homocysteine | − 231.68 (− 582.59, 119.24) | − 239.46 (− 592.17, 113.25) | − 382.58 (− 906.63, 141.46) | ||||
Hyperhomocysteinemia | −202.33 (− 2782.91, 2378.25) | 0.67 | −215.25 (− 3567.24, 3136.73) | 0.63 | − 475.41 (− 2951.40, 2000.58) | 0.54 | |
B12 > median | −254.95 (− 1069.99, 560.09) | − 218.68 (− 1018.69, 581.33) | − 265.88 (− 1216.77, 685.01) | ||||
B12 < =median | − 204.70 (− 594.89, 185.49) | 0.92 | −183.57 (− 571.92, 204.78) | 0.81 | − 425.17 (− 1116.72, 266.38) | 0.86 | |
Folate >median | −238.02 (− 606.24, 130.21) | −210.04 (− 580.34, 160.25) | −313.47 (− 1004.61, 377.68) | ||||
Folate <=median | −231.13 (− 987.04, 524.78) | 0.40 | −210.99 (− 970.89, 548.9) | 0.42 | −475.40 (− 1354.61, 403.81) | 0.67 | |
Homocysteine <median | − 291.31 (−1004.29, 421.68) | −195.95 (− 915.66, 523.77) | −72.96 (− 967.59, 821.68) | ||||
Homocysteine > = median | − 360.07 (− 816.94, 96.80) | 0.08 | − 422.54 (− 866.64, 21.56) | 0.07 | − 597.58 (− 1327.28, 132.12) | 0.88 |