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Table 3 Associations (95% CI) between biomarkers and birth weight (grams) within levels of one-carbon metabolism factors

From: Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight

Biomarker

Level

Model 1a β (95% CI)

p

Model 2b β (95% CI)

p

Model 3c β (95% CI)

p

% U-iAs

Normal B12

2.07 (−22.72, 26.85)

 

4.31 (− 20.01, 28.64)

 

1.08 (−26.06, 28.22)

 

B12 deficient

−16.81 (− 42, 8.37)

0.19

− 18.27 (− 43.57, 7.03)

0.15

− 16.10 (− 43.96, 11.77)

0.30

Normal homocysteine

−3.12 (− 20.05, 13.81)

 

− 3.29 (− 20.25, 13.66)

 

− 2.73 (− 20.69, 15.22)

 

Hyperhomocysteinemia

−79.06 (− 196.3, 38.19)

0.16

− 81.20 (− 215.70, 53.31)

0.15

− 59.58 (− 161.44, 42.27)

0.31

B12 > median

1.99 (− 18.07, 22.04)

 

3.61 (− 16.06, 23.28)

 

0.10 (− 21.56, 21.77)

 

B12 < =median

− 22.79 (− 54.67, 9.09)

0.18

− 24.60 (− 56.30, 7.11)

0.15

−13.66 (− 48.67, 21.35)

0.47

Folate >median

0.83 (− 17.05, 18.71)

 

0.81 (− 17.25, 18.86)

 

−1.27 (− 20.05, 17.51)

 

Folate <=median

−17.57 (− 53.40, 18.26)

0.37

− 17.58 (− 53.55, 18.39)

0.38

− 8.90 (− 49.20, 31.40)

0.71

Homocysteine <median

2.07 (− 16.33, 20.46)

 

1.44 (− 16.93, 19.81)

 

3.20 (− 16.47, 22.87)

 

Homocysteine > = median

− 27.96 (− 62.33, 6.41)

0.07

−31.19 (− 64.67, 2.28)

0.07

− 28.63 (− 67.80, 10.54)

0.12

% U-MMAs

Normal B12

− 14.57 (− 57.98, 28.85)

 

− 6.43 (− 49.81, 36.95)

 

−17.65 (− 68.03, 32.73)

 

B12 deficient

−28.69 (− 53.97, − 3.42)

0.47

− 28.37 (− 53.63, − 3.10)

0.45

−24.52 (− 53.14, 4.09)

0.71

Normal homocysteine

−21.71 (− 44.14, 0.72)

 

− 21.53 (− 44.08, 1.03)

 

− 21.91 (− 47.24, 3.42)

 

Hyperhomocysteinemia

−63.29 (− 154.77, 28.19)

0.41

−90.66 (− 193.61, 12.30)

0.39

−35.73 (− 119.84, 48.38)

0.76

B12 > median

− 10.51 (− 38.16, 17.14)

 

−5.30 (− 32.72, 22.12)

 

−11.86 (− 43.30, 19.57)

 

B12 < =median

− 46.23 (− 82.26, − 10.19)

0.12

− 42.57 (− 78.65, − 6.49)

0.12

− 41.54 (− 84.48, 1.40)

0.22

Folate >median

−18.46 (− 43.09, 6.18)

 

−17.69 (−42.41, 7.03)

 

−20.58 (− 47.45, 6.29)

 

Folate <=median

−23.45 (− 65.74, 18.84)

0.88

−18.87 (− 62.27, 24.53)

0.94

− 14.34 (− 65.27, 36.59)

0.82

Homocysteine <median

−8.40 (− 38.64, 21.84)

 

−9.69 (− 39.89, 20.52)

 

−11.77 (− 47.49, 23.94)

 

Homocysteine > = median

−33.76 (− 64.90, − 2.61)

0.21

− 28.99 (− 59.88, 1.91)

0.23

−28.20 (−62.70, 6.29)

0.51

% U-DMAs

Normal B12

1.25 (−15.84, 18.34)

 

−1.10 (− 18, 15.80)

 

1.95 (−17.05, 20.94)

 

B12 deficient

15.72 (0.92, 30.52)

0.12

16.11 (1.30, 30.91)

0.11

14.53 (−2.34, 31.41)

0.23

Normal homocysteine

6.45 (−4.53, 17.42)

 

6.45 (−4.55, 17.45)

 

6.04 (−5.92, 18)

 

Hyperhomocysteinemia

47.81 (−9.56, 105.17)

0.16

57.96 (−5.51, 121.43)

0.15

31.83 (−20.20, 83.86)

0.38

B12 > median

1.44 (−11.42, 14.31)

 

−0.37 (−13.05, 12.32)

 

2.35 (−11.82, 16.52)

 

B12 < =median

24.85 (4.27, 45.42)

0.05

24.22 (3.80, 44.64)

0.05

20.13 (−4.31, 44.57)

0.18

Folate >median

3.59 (−7.90, 15.08)

 

3.48 (−8.10, 15.06)

 

4.70 (−7.52, 16.92)

 

Folate <=median

15.25 (−8.53, 39.04)

0.40

13.78 (−10.32, 37.89)

0.42

8.91 (−19.51, 37.33)

0.76

Homocysteine <median

0.50 (−12.34, 13.34)

 

1.04 (−11.79, 13.86)

 

0.18 (−13.96, 14.33)

 

Homocysteine > = median

19.8 (1.47, 38.12)

0.05

18.86 (0.95, 36.77)

0.05

18.63 (−2.23, 39.49)

0.13

C-tAs

Normal B12

−91.24 (− 1287.92, 1105.43)

 

−20.88 (− 1195.59, 1153.83)

 

−304.12 (− 1645.15, 1036.91)

 

B12 deficient

− 243.29 (−598.57, 111.98)

0.40

− 230.77 (− 586.09, 124.55)

0.38

− 359.19 (− 932.36, 213.97)

0.41

Normal homocysteine

− 231.68 (− 582.59, 119.24)

 

− 239.46 (− 592.17, 113.25)

 

− 382.58 (− 906.63, 141.46)

 

Hyperhomocysteinemia

−202.33 (− 2782.91, 2378.25)

0.67

−215.25 (− 3567.24, 3136.73)

0.63

− 475.41 (− 2951.40, 2000.58)

0.54

B12 > median

−254.95 (− 1069.99, 560.09)

 

− 218.68 (− 1018.69, 581.33)

 

− 265.88 (− 1216.77, 685.01)

 

B12 < =median

− 204.70 (− 594.89, 185.49)

0.92

−183.57 (− 571.92, 204.78)

0.81

− 425.17 (− 1116.72, 266.38)

0.86

Folate >median

−238.02 (− 606.24, 130.21)

 

−210.04 (− 580.34, 160.25)

 

−313.47 (− 1004.61, 377.68)

 

Folate <=median

−231.13 (− 987.04, 524.78)

0.40

−210.99 (− 970.89, 548.9)

0.42

−475.40 (− 1354.61, 403.81)

0.67

Homocysteine <median

− 291.31 (−1004.29, 421.68)

 

−195.95 (− 915.66, 523.77)

 

−72.96 (− 967.59, 821.68)

 

Homocysteine > = median

− 360.07 (− 816.94, 96.80)

0.08

− 422.54 (− 866.64, 21.56)

0.07

− 597.58 (− 1327.28, 132.12)

0.88

  1. p-values represent a likelihood ratio test comparing the main effects model to a full model including an interaction term
  2. aModel 1 adjusts for smoking status during pregnancy, maternal age, and U-tAs
  3. bModel 2 adjusts for smoking status during pregnancy, maternal age, U-tAs, and additional one-carbon metabolism factors
  4. cModel 3 adjusts for smoking status during pregnancy, maternal age, and U-tAs and excludes mothers reporting recent seafood intake