Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight

Clark, Jeliyah; Bommarito, Paige; Stýblo, Miroslav; Rubio-Andrade, Marisela; García-Vargas, Gonzalo G.; Gamble, Mary V.; Fry, Rebecca C.

doi:10.1186/s12940-022-00875-7

Environmental Health

Table 4 Associations (95% CI) between arsenic biomarkers and gestational age (weeks) within levels of one-carbon metabolism factors

From: Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight

Biomarker	Level	Model 1^a β (95% CI)	p	Model 2^b β (95% CI)	p	Model 3^c β (95% CI) N = 145	p
% U-iAs	Normal B12	0 (− 0.05, 0.05)		0 (− 0.05, 0.05)		− 0.01 (− 0.06, 0.05)
	B12 deficient	0.01 (− 0.06, 0.08)	0.87	0.01 (− 0.06, 0.08)	0.93	0.01 (− 0.07, 0.09)	0.97
	Normal homocysteine	0 (− 0.04, 0.05)		0.02 (− 0.03, 0.07)		0 (− 0.05, 0.05)
	Hyperhomocysteinemia	− 0.02 (− 0.19, 0.15)	0.92	− 0.02 (− 0.10, 0.06)	0.92	− 0.02 (− 0.26, 0.22)	0.90
	B12 > median	0.02 (− 0.04, 0.07)		0.03 (− 0.02, 0.08)		0.01 (− 0.04, 0.07)
	B12 < =median	− 0.02 (− 0.10, 0.06)	0.36	− 0.06 (− 0.15, 0.04)	0.39	0 (− 0.09, 0.09)	0.65
	Folate >median	0.02 (− 0.03, 0.07)		0 (− 0.04, 0.05)		0.02 (− 0.03, 0.07)
	Folate <=median	− 0.05 (− 0.15, 0.04)	0.09	− 0.01 (− 0.20, 0.19)	0.07	− 0.05 (− 0.15, 0.06)	0.21
	Homocysteine <median	0.01 (− 0.05, 0.06)		0.01 (− 0.05, 0.06)		0 (− 0.06, 0.05)
	Homocysteine > = median	− 0.01 (− 0.10, 0.07)	0.63	− 0.01 (− 0.10, 0.08)	0.67	0.01 (− 0.09, 0.11)	0.96
% U-MMAs	Normal B12	−0.01 (− 0.11, 0.08)		− 0.02 (− 0.11, 0.08)		− 0.03 (− 0.13, 0.07)
	B12 deficient	−0.06 (− 0.13, 0.02)	0.35	− 0.06 (− 0.13, 0.01)	0.36	−0.04 (− 0.12, 0.04)	0.72
	Normal homocysteine	−0.04 (− 0.10, 0.02)		0.01 (− 0.07, 0.08)		− 0.04 (− 0.11, 0.03)
	Hyperhomocysteinemia	0.01 (− 0.13, 0.15)	0.67	−0.09 (− 0.18, 0)	0.57	0.03 (− 0.16, 0.21)	0.66
	B12 > median	0 (−0.07, 0.08)		0.01 (− 0.06, 0.08)		0 (−0.08, 0.08)
	B12 < =median	−0.09 (− 0.17, 0)	0.10	− 0.11 (− 0.22, 0)	0.08	−0.05 (− 0.16, 0.06)	0.43
	Folate >median	0 (−0.07, 0.07)		−0.04 (− 0.11, 0.02)		0.01 (− 0.07, 0.08)
	Folate <=median	−0.1 (− 0.21, 0)	0.08	0 (− 0.16, 0.17)	0.04	− 0.12 (− 0.24, 0.01)	0.11
	Homocysteine <median	−0.06 (− 0.15, 0.03)		−0.06 (− 0.15, 0.03)		−0.07 (− 0.17, 0.03)
	Homocysteine > = median	−0.02 (− 0.10, 0.06)	0.40	−0.02 (− 0.10, 0.06)	0.44	0.01 (− 0.08, 0.10)	0.25
% U-DMAs	Normal B12	0 (−0.03, 0.04)		0 (−0.03, 0.04)		0.01 (−0.03, 0.05)
	B12 deficient	0.02 (−0.03, 0.06)	0.41	0.02 (−0.03, 0.06)	0.44	0.01 (−0.04, 0.06)	0.70
	Normal homocysteine	0.01 (−0.02, 0.04)		−0.01 (− 0.04, 0.02)		0.01 (− 0.02, 0.04)
	Hyperhomocysteinemia	0 (−0.09, 0.09)	0.90	0.04 (−0.02, 0.09)	0.84	−0.01 (− 0.13, 0.12)	0.89
	B12 > median	−0.01 (− 0.04, 0.03)		− 0.01 (− 0.04, 0.02)		0 (− 0.04, 0.03)
	B12 < =median	0.04 (− 0.02, 0.09)	0.11	0.06 (0, 0.12)	0.11	0.02 (−0.05, 0.08)	0.42
	Folate >median	−0.01 (− 0.04, 0.02)		0.01 (− 0.02, 0.04)		− 0.01 (− 0.04, 0.02)
	Folate <=median	0.06 (0, 0.12)	0.03	0 (−0.10, 0.11)	0.01	0.06 (−0.01, 0.13)	0.07
	Homocysteine <median	0.01 (−0.03, 0.05)		0.01 (−0.03, 0.05)		0.01 (−0.03, 0.05)
	Homocysteine > = median	0.01 (−0.04, 0.06)	0.91	0.01 (−0.04, 0.06)	0.89	−0.01 (− 0.06, 0.05)	0.70
C-tAs	Normal B12	1.53 (−0.01, 3.08)		1.50 (−0.04, 3.04)		1.46 (−0.06, 2.98)
	B12 deficient	0.39 (−0.63, 1.41)	0.10	0.38 (−0.65, 1.41)	0.11	0.18 (−1.47, 1.83)	0.06
	Normal homocysteine	0.94 (0.03, 1.85)		1.91 (0.44, 3.38)		0.99 (−0.28, 2.26)
	Hyperhomocysteinemia	−0.37 (−3.33, 2.60)	0.77	0.28 (−0.74, 1.31)	0.83	−0.97 (−4.34, 2.40)	0.63
	B12 > median	2.16 (0.70, 3.62)		0.18 (−0.84, 1.20)		1.90 (0.38, 3.43)
	B12 < =median	0.30 (−0.71, 1.31)	0.14	2.41 (0.87, 3.95)	0.11	0.10 (−1.76, 1.95)	0.07
	Folate >median	0.15 (−0.86, 1.16)		0.96 (0.05, 1.88)		−0.45 (−2.32, 1.41)
	Folate <=median	2.38 (0.87, 3.88)	0.21	−0.42 (−4.25, 3.41)	0.20	2.34 (0.74, 3.93)	0.86
	Homocysteine <median	2.26 (0.54, 3.98)		2.32 (0.57, 4.07)		2.87 (0.91, 4.83)
	Homocysteine > = median	0.48 (−0.66, 1.62)	0.10	0.53 (−0.63, 1.68)	0.09	−0.37 (−2.16, 1.42)	0.18

p-values represent a likelihood ratio test comparing the main effects model to a full model including an interaction term
NS Not significant
^aModel 1 adjusts for smoking status during pregnancy, maternal age, and U-tAs
^bModel 2 adjusts for smoking status during pregnancy, maternal age, U-tAs, and additional one-carbon metabolism factors
^cModel 3 adjusts for smoking status during pregnancy, maternal age, and U-tAs and excludes mothers reporting recent seafood intake

Back to article page

ISSN: 1476-069X

Contact us

General enquiries: journalsubmissions@springernature.com