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Table 4 Reference doses derived from rodent studies that full-filled all inclusion criteria and passed RoB assessment using the body burden approach

From: Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments

Congener /Study

Tier

Species

LOAEL (µg/kg/d)

NOAEL (µg/kg/d)

BB at NOAEL (µg/kg/d)

EHDI (µg/kg/d)

RfD (µg/kg/d)

PCB-118

He et al. 2020

1

Mouse

20 a)

6.67 a)

35.5

0.00725

0.0029

PCB-126

Wakui et al. 2010

1

Rat

0.25 a)

0.025 a)

0.154

0.00018

0.000073

PCB-132

Hsu et al. 2007

2

Rat

1000 b)

333.33 b)

300

0.0570

0.0228

PCB-132

Hsu et al. 2003

2

Rat

9600 b)

3200 b)

2880

0.547

0.219

PCB-149

Hsu et al. 2003

2

Rat

96,000 b)

9600 b)

8640

1.641

0.656

PCB-153

Xiao et al. 2010

1

Rat

2500 a)

25 a)

111

0.0147

0.00586

PCB-169

Xiao et al. 2011

1

Rat

25 a)

8.33 a)

51.2

0.0133

0.00533

  1. The reference doses chosen for mixture risk assessment are shown in bold
  2. The NOAEL values shown in italics are extrapolations from studies where only a LOAEL, but no NOAEL was observed. A NOAEL was extrapolated by dividing the LOAEL by a factor of 3
  3. LOAEL Lowest observed adverse effect level, NOAEL No observed adverse effect level, BB Critical body burden, EHDI Estimated human daily intake associated with rodent BB at NOAEL, RfD Reference dose derived by dividing the EHDI by 2.5
  4. a)Repeat administration, BB estimated taking absorption and excretion into account
  5. b)Single administration