Table 1 Mean ppFEV1 within and beyond 4 km of a PCS in pwCF in the UK in 2016. p-value < 0.05 are shown in bold
Mean ppFEV1 | ||||
|---|---|---|---|---|
Characteristics | n (%) | mean (SD) | mean (SD) | p-value |
≤ 4 km | > 4 km | |||
n = 7,800 (100%) | (n = 866; 11.1%) | (n = 6,934; 88.9%) | ||
Age (years) | 0.0265 | |||
Children < 6 | -a | |||
6-15 | 2,370 (30.4) | 85.0 (16.7) | 86.1 (17.2) | |
Adults ≥ 16 | 5,430 (69.4) | 62.2 (23.7) | 64.3 (23.6) | |
Sex | < 0.001 | |||
Female | 3,629 (46.5) | 66.7 (24.5) | 70.8 (23.8) | |
Male | 4,171 (53.5) | 69.1 (24.0) | 71.2 (24.3) | |
Genotype | 0.001 | |||
Homozygous F508del | 3,825 (49.0) | 66.1 (24.5) | 68.9 (24.0) | |
F508del/MF | 1,511 (19.4) | 66.3 (23.2) | 69.0 (24.1) | |
RF/other | 874 (11.2) | 75.9 (24.6) | 79.1 (22.5) | |
F508del/other | 558 (7.2) | 70.3 (23.1) | 73.7 (24.6) | |
Gating/anyb | 494 (6.3) | 73.3 (25.4) | 75.9 (23.5) | |
MF/MF | 249 (3.2) | 67.0 (18.5) | 69.1 (21.9) | |
Other/other | 158 (2.0) | 77.5 (21.9) | 73.3 (23.6) | |
MF/other | 131 (1.7) | 63.1 (28.3) | 76.4 (22.8) | |
P. aeruginosa culture | 0.0016 | |||
Negative | 3,984 (51.1) | 76.3 (22.3) | 79.5 (21.7) | |
Positive | 3816 (48.9) | 60.4 (23.5) | 62.4 (23.3) | |
Deprivation quintile (Townsend) | 0.002 | |||
Q1 (least deprived) | 1,612 (20.7) | 67.8 (23.6) | 73.3 (23.6) | |
Q2 | 1,615 (20.7) | 65.8 (26.1) | 71.1 (24.7) | |
Q3 | 1,666 (21.4) | 68.7 (22.9) | 70.8 (24.1) | |
Q4 | 1,547 (19.8) | 69.2 (24.3) | 70.3 (23.5) | |
Q5 (most deprived) | 1,360 (17.4) | 68.3 (24.6) | 69.3 (24.1) | |
Rural and Urban | 0.001 | |||
Rural | 1,500 (19.2) | 66.2 (24.6) | 72.4 (24.1) | |
Urban | 6,300 (80.8) | 68.3 (24.2) | 70.7 (24.0) | |