Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study

Table 3 Linear and Poisson regression analysis of the relationship between ppFEV₁ and #IVdays to residential postcode distance from PCS among children and adults with CF in the UK in 2016. p-value < 0.05 are shown in bold

Residential postcode distance	ppFEV₁					#IVdays
Residential postcode distance	Mean ppFEV₁	Coeff	95% CI	*p-value*	AIC	mean #IVdays	Coeff	Exp (B)	95% CI	*p-value*	AIC
Children (6 -15 years) (n = 2,370)						Children (0 -15 years) (n = 3,931)
Unadjusted				0.391	19,297.9					0.087	103,952.3
≤ 4 km	85.0	-0.75	-2.46, 0.96			9.8	0.02	1.02	0.99, 1.05
> 4 km	86.1	1.00	-			9.5		1.00	-
Adjusted^a				0.358	18,887.6					0.623	84,834.0
≤ 4 km	86.0^b	-0.74	-2.31, 0.83			10.3	0.01	1.01^b	0.99, 1.04
> 4 km	86.8^b	1.00	-			10.3		1.00^b
Adults (16—86 years) (n = 5,430)						Adults (16—86 years) (n = 5,430)
Unadjusted				0.044	47,438.5					< 0.001	231,519.0
≤ 4 km	62.2	-1.44	-2.84, -0.04			22.4	0.04	1.04	1.03, 1.06
> 4 km	64.3	1.00	-			21.0		1.00	-
Adjusted^a				0.088	46,040.1					< 0.001	187,492.7
≤ 4 km	64.4^b	-1.07	-2.29, 0.16			19.4	0.02	1.02^b	1.01, 1.04
> 4 km	66.3^b	1.00	-			18.4		1.00^b

ppFEV₁ percent predicted FEV₁, #IVdays Number of days on IV antibiotics for PEx, pwCF people with cystic fibrosis, PCS permitted composting site
^aAdjusted for age, sex, BMI (children model adjusted for BMI percentile and adult model adjusted for absolute BMI), genotype, P. aeruginosa and deprivation
^bcalculated using ANCOVA (Analysis of Covariance) adjusting for age, sex, BMI (children model adjusted for BMI percentile and adult model adjusted for absolute BMI), genotype, P. aeruginosa and deprivation

ISSN: 1476-069X