Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study

Table 4 Respiratory microbiology, fungal disease and mean ppFEV₁ among children and adults with CF within and beyond 4 km of PCS in the UK in 2016. p-value < 0.05 are shown in bold

	Distance band			Distance band
	Crude			Adjusted*
	≤ 4 km	> 4 km	*p-value*	≤ 4 km	> 4 km	*p-value*
Total Number of pwCF (n)	866	6,934	-	-	-	-
Number of pwCF who had culture (n)**	842	6,730	-	-	-	-
*A. fumigatus*
*n (point prevalence %)*	129 (15.3)	1,041 (15.5)	0.911
mean ppFEV₁
Children	77.2	79.0	0.662	78.3	80.4	0.631
Adults	55.9	62.1	0.001	58.2	62.0	0.005
ABPA
*n (point prevalence %)*	76 (8.8)	551 (7.9)	0.397
mean ppFEV₁
Children	81.2	75.3	0.229	86.6	82.6	0.179
Adults	60.2	59.1	0.717	60.3	60.1	0.696
*Candida spp.*
*n (point prevalence %)*	180 (21.4)	1,195 (17.8)	0.010
mean ppFEV₁
Children	79.6	79.3	0.929	84.0	82.9	0.921
Adults	53.6	57.8	0.048	56.9	59.9	0.029
*P. aeruginosa*
*n (point prevalence %)*	439 (52.1)	3,377 (50.2)	0.284
mean ppFEV₁
Children	80.5	82.3	0.436	80.9	84.1	0.399
Adults	56.8	58.1	0.280	58.5	59.6	0.240
*S. aureus*
*n (point prevalence %)*	76 (8.3)	558 (9.0)	0.469
mean ppFEV₁
Children	71.2	76.1	0.541	63.7	70.8	0.472
Adults	58.0	56.9	0.690	59.1	59.0	0.663

Aspergillus fumigatus = A. fumigatus, Pseudomonas aeruginosa = P. aeruginosa, Staphylococcus aureus = S. aureus
^*Adjusted for age, sex, BMI (children model adjusted for BMI percentile and adult model adjusted for absolute BMI), genotype and deprivation
^*^*(Sputum/ Cough Swab/ Bronchoscopy); ppFEV₁ percent predicted with FEV1, pwCF people with cystic fibrosis, ABPA Allergic Bronchopulmonary Aspergillosis, PCS permitted composting site; Children = 6—15 years; adult = 16—86 years

ISSN: 1476-069X