Approach | Intended Use | Method |
---|---|---|
Default adjustment factor (AF) | Adjust for total intra-species variability. | AFH = 10. |
Default subfactor approach | Adjust for intra-species variability in metabolism (TK) and tissue response (TD). | AFH ≤ 10 (usually 3X each for AFH-TK and AFH-TD). |
Chemical-specific adjustment factor (CSAF) or data-derived extrapolation factor (DDEF) | Adjust for chemical-specific intra-species differences in metabolism (TK) and tissue response (TD). | AFH-TK and AFH-TD based on case-by-case TK/TD data. |