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Table 2 Association between Bisphenols and sex hormones (Total Testosterone, Estradiol, Sex hormone-binding globulin) among the US males in NHANES 2011-2016

From: Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

Bisphenols

Total Testosterone(ng/dL)

β(95%CI)

Estradiol (pg/ml)

β(95%CI)

Sex hormone-binding globulin (SHBG) (nmol/L)

β(95%CI)

 

Model 1

Model 2

Model 1

Model 2

Model 1

Model 2

BPA (Continuous)

-0.156 (-1.248, 0.936) 0.779

0.611 (-0.805, 2.026) 0.398

-0.009 (-0.078, 0.061) 0.807

-0.039 (-0.143, 0.064) 0.456

0.135 (-0.024, 0.294) 0.096

0.364 (0.158, 0.571) 0.001

BPA (Quartiles)

 Q1

0

0

0

0

0

0

 Q2

-6.109 (-26.68, 14.46) 0.561

-6.314 (-25.840, 13.213) 0.526

-1.430 (-2.835, -0.025) 0.046

-1.534 (-2.948, -0.120) 0.034

-3.933 (-7.329, -0.537) 0.024

0.746 (-2.209, 3.699) 0.621

 Q3

-28.229 (-48.657, -7.801) 0.007

-23.175 (-43.634, -2.715) 0.027

-1.129 (-2.529, 0.272) 0.114

-1.667 (-3.154, -0.180) 0.028

-5.136 (-8.482, -1.791) 0.003

-1.784 (-4.856, 1.289) 0.255

 Q4

-15.770 (-36.341, 4.801) 0.1335

-6.709 (-29.146, 15.729) 0.558

0.023 (-1.390, 1.436) 0.975

-0.876 (-2.499, 0.747) 0.290

0.228 (-3.148, 3.604) 0.895

4.072 (0.746, 7.397) 0.017

P for trend

0.168

0.924

0.369

0.938

0.252

0.005

 BPS (Continuous)

-0.165 (-1.511, 1.181) 0.810

0.079 (-1.162, 1.321) 0.900

-0.011 (-0.085, 0.064) 0.774

-0.018 (-0.091, 0.056) 0.635

0.276 (0.068, 0.484) 0.009

0.250 (0.071, 0.429) 0.006

BPS (Quartiles)

 Q1

0

0

0

0

0

0

 Q2

-27.161 (-54.670, 0.377) 0.053

-17.705 (-43.628, 8.218) 0.181

0.706 (-0.829, 2.241) 0.366

0.306 (-1.236, 1.849) 0.697

-4.067 (-7.821, -0.313) 0.034

-2.195 (-5.465, 1.074) 0.188

 Q3

11.620 (-16.537, 39.776) 0.419

20.794 (-6.427, 48.016) 0.135

2.067 (0.496, 3.636) 0.011

1.738 (0.118, 3.357) 0.036

-1.482 (-5.312, 2.349) 0.448

1.333 (-2.088, 4.754) 0.445

 Q4

-11.482 (-39.870, 16.906) 0.428

-8.295 (-36.676, 20.085) 0.567

0.503 (-1.079, 2.086) 0.533

0.140 (-1.548, 1.827) 0.871

-4.017 (-7.868, -0.165) 0.041

-1.678 (-5.254, 1.897) 0.358

P for trend

0.963

0.775

0.856

0.592

0.222

0.549

 BPF (Continuous)

0.078 (-0.494, 0.649) 0.790

0.575 (0.047, 1.103) 0.033

0.017 (-0.015, 0.049) 0.295

0.010 (-0.022, 0.042) 0.542

0.008 (-0.066, 0.083) 0.825

0.025 (-0.039, 0.089) 0.444

BPF (Quartiles)

 Q1+2

0

0

0

0

0

0

 Q3

-8.203 (-30.453, 14.047) 0.470

-13.633 (-34.227, 6.963) 0.195

-0.278 (-1.518, 0.961) 0.660

-0.372 (-1.599, 0.855) 0.553

-0.941 (-3.914, 2.032) 0.535

-2.453 (-4.997, 0.090) 0.059

 Q4

11.352 (-10.122, 32.825) 0.300

18.062 (-2.399, 38.522) 0.084

1.446 (0.255, 2.637) 0.017

1.172 (-0.043, 2.384) 0.059

-1.266 (-4.153, 1.622) 0.390

-1.659 (-4.188, 0.870) 0.199

P for trend

0.451

0.223

0.634

0.468

0.527

0.058

  1. Model 1: crude model
  2. Model 2: adjusted for age, race, BMI, poverty income ratio (PIR), smoking status, urinary creatinine, and time of sample collection, six-month time period.
  3. 95%CI 95% Confidence interval