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Table 5 Associations Between Specific Windows of Prenatal Ambient Air Pollution Exposure and Neurodevelopmental Outcomes at 2 Years

From: Prenatal exposure to ambient air pollution is associated with neurodevelopmental outcomes at 2 years of age

Outcome

Beta

95% CI

Gross Motor Score

 NO2 1 m (early pregnancy)

-0.35

(-0.69, -0.002)

Composite Cognitive Score

 NO2 9 m (late pregnancy)

-1.76

(-3.50, -0.03)

Composite Language Score

 PM2.5 6 m (mid pregnancy)

-0.84

(-1.58, -0.09)

 PM2.5 7 m (late pregnancy)

-1.25

(-2.09, -0.40)

 PM2.5 8 m (late pregnancy)

-0.73

(-1.37, -0.08)

 PM10 5 m (mid pregnancy)

-0.41

(-0.78, -0.03)

 PM10 6 m (mid pregnancy)

-0.47

(-0.86, -0.08)

 PM10 7 m (mid pregnancy)

-0.53

(-1.01, -0.05)

 NO2 8 m (late pregnancy)

-1.15

(-2.23, -0.06)

Scaled Language Score

 PM2.5 6 m (mid pregnancy)

-0.28

(-0.53, -0.03)

 PM2.5 7 m (late pregnancy)

-0.42

(-0.71, -0.13)

 PM2.5 8 m (late pregnancy)

-0.25

(-0.47, -0.02)

 PM10 5 m (mid pregnancy)

-0.13

(-0.26, -0.01)

 PM10 6 m (mid pregnancy)

-0.15

(-0.29, -0.02)

 PM10 7 m (late pregnancy)

-0.17

(-0.34, -0.01)

 NO2 1 m (early pregnancy

-0.97

(-1.91, -0.03)

 NO2 8 m (late pregnancy)

-0.38

(-0.75, -0.01)

Expressive Communication Score

 PM2.5 7 m (late pregnancy)

-0.16

(-0.30, -0.01)

 PM10 4 m (mid pregnancy)

-0.09

(-0.17, -0.01)

 PM10 5 m (mid pregnancy)

-0.08

(-0.15, -0.01)

 PM10 6 m (mid pregnancy)

-0.08

(-0.15, -0.004)

Receptive Communication Score

 PM2.5 7 m (late pregnancy)

-0.11

(-0.20, -0.01)

 PM2.5 8 m (late pregnancy)

-0.15

(-0.27, -0.03)

 PM2.5 9 m (late pregnancy)

-0.20

(-0.34, -0.05)

 PM10 7 m (late pregnancy)

-0.10

(-0.20, -0.01)

 PM10 8 m (late pregnancy)

-0.13

(-0.25, -0.01)

 PM10 9 m (late pregnancy)

-0.15

(-0.31, -0.003)

 NO2 8 m (late pregnancy)

-0.22

(-0.43, -0.01)

 NO2 9 m (late pregnancy)

-0.36

(-0.67, -0.06)

  1. Table shows the significant associations between monthly ambient air pollution exposure during pregnancy and cognitive outcomes at 2 years of age where non-statistically significant findings are not shown. Effect estimates and 95% confidence intervals (CI) were obtained from distributed lag models (DLMs) that adjusted for socioeconomic status (SES), breast feedings per day, gestational age, pre-pregnancy BMI, infant birthweight, and infant sex. Effect estimates are scaled to an IQR increase in exposure (IQR PM2.5 = 3 µg/m3, IQR PM10 = 8 µg/m3, IQR NO2 = 9 ppb)