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Table 3 Studies evaluating maternal age as a determinant of maternal or neonatal PFAS concentrations by PFAS, study design, and findings

From: Determinants of maternal and neonatal PFAS concentrations: a review

PFAS (study design)a

N

Positive findings

N

Negative findings

N

Null findings

Legacy PFAS

 PFOA (C/L)

1

[42]

4

[61, 62, 73, 78]

6

[65, 68, 76, 81, 82, 88]

 PFOA (C-S)

5

[64, 86, 87, 91, 94]

1

[92]

9

[66, 67, 72, 74, 77, 83, 89, 90, 93]

 PFOS (C/L)

3

[42, 68, 82]

1

[78]

7

[61, 62, 65, 73, 76, 81, 88]

 PFOS (C-S)

6

[83, 86, 87, 89, 93, 94]

–

–

9

[64, 66, 67, 72, 74, 77, 91, 92, 94]

 PFNA (C/L)

3

[65, 78, 81]

–

–

5

[42, 68, 73, 76, 82]

 PFNA (C-S)

7

[66, 86, 87, 89, 91, 93, 94]

–

–

5

[64, 72, 74, 77, 83]

 PFHxS (C/L)

3

[42, 81, 88]

3

[61, 62, 78]

5

[65, 68, 73, 76, 82]

 PFHxS (C-S)

6

[83, 86, 89, 91, 93, 94]

–

–

5

[66, 74, 77, 87, 90]

Other PFAS

 Et-PFOSA-AcOH (C/L)

–

–

–

–

1

[78]

 Me-PFOSA-AcOH (C/L)

–

–

1

[78]

1

[42]

 NMeFOSAA (C-S)

–

–

–

–

1

[74]

 PFBS (C-S)

1

[86]

–

–

–

–

 PFDeA (C/L)

1

[65]

–

–

3

[68, 73, 82]

 PFDeA (C-S)

2

[86, 87]

–

–

4

[74, 77, 90, 93]

 PFDoA (C/L)

2

[73, 88]

–

–

1

[82]

 PFDoA (C-S)

1

[87]

–

–

1

[86]

 PFHpA (C/L)

–

–

–

–

2

[73, 88]

 PFHpA (C-S)

–

–

–

–

1

[86]

 PFHpS (C/L)

–

–

–

–

1

[65]

 PFHpS (C-S)

1

[93]

–

–

–

–

 PFOSA (C-S)

–

–

–

–

1

[86]

 PFPeA (C-S)

–

–

–

–

2

[74, 90]

 PFTrDA (C/L)

1

[82]

–

–

–

–

 PFTrDA (C-S)

1

[87]

–

–

–

–

 PFUnDA (C/L)

3

[65, 73, 82]

–

–

2

[68, 88]

 PFUnDA (C-S)

3

[86, 89, 93]

–

–

4

[64, 74, 87, 90]

 6:2 Cl-PFESA (C/L)

1

[88]

–

–

–

–

 ΣPFAS (C-S)

1

[87]

–

–

1

[90]

  1. a C/L Cohort/longitudinal studies, C-S Cross-sectional studies, PFOA Perfluorooctanoic acid; PFOS: Perfluorooctane sulfonic acid, PFNA Perfluorononanoic acid, PFHxS perfluorohexane sulfonate, Et-PFOSA-AcOH 2-(N-Ethyl-perfluorooctane sulfonamido) acetic acid, Me-PFOSA-AcOH 2-(N-Methyl-perfluorooctane sulfonamido) acetic acid, NMeFOSAA N-methyl perfluorooctanesulfonamidoacetic acid, PFBS Perfluorobutane sulfonate, PFDeA Perfluorodecanoic acid, PFDoA Perfluorododecanoic acid, PFHpA Perfluoroheptanoic acid; PFHpS Perfluoroheptanesulfonic acid; PFOSA Perfluorooctanesulfonamide; PFPeA: perfluorovaleric acid, PFTrDA Perfluorotridecanoic acid (PFTrDA), PFUnDA Perfluoroundecanoic acid, 6:2 Cl-PFESA 6:2 chlorinated polyfluorinated ether sulfonate