Children’s Environmental Health

Health effects of early-life exposures to environmental hazards

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  1. Research

    Genetic and epigenetic susceptibility of airway inflammation to PM2.5 in school children: new insights from quantile regression

    The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that has proved to be useful in investigations of genetic and epigenetic airway susceptibility to ambient air p...

    Yue Zhang, Muhammad T. Salam, Kiros Berhane, Sandrah P. Eckel, Edward B. Rappaport, William S. Linn, Rima Habre, Theresa M. Bastain and Frank D. Gilliland

    Environmental Health 2017 16:88

    Published on: 18 August 2017

  2. Research

    Maternal occupational exposure and oral clefts in offspring

    Previous studies suggest that periconceptional maternal occupational exposure to solvents and pesticides increase the risk of oral clefts in the offspring. Less is known about the effect of occupational exposu...

    Nynke Spinder, Jorieke E. H. Bergman, H. Marike Boezen, Roel C. H. Vermeulen, Hans Kromhout and Hermien E. K. de Walle

    Environmental Health 2017 16:83

    Published on: 4 August 2017

  3. Research

    Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

    Neurodevelopment is a complex process involving both genetic and environmental factors. Prenatal exposure to lead (Pb) has been associated with lower performance on neurodevelopmental tests. Adverse neurodevel...

    Zhaoxi Wang, Birgit Claus Henn, Chaolong Wang, Yongyue Wei, Li Su, Ryan Sun, Han Chen, Peter J. Wagner, Quan Lu, Xihong Lin, Robert Wright, David Bellinger, Molly Kile, Maitreyi Mazumdar, Martha Maria Tellez-Rojo, Lourdes Schnaas…

    Environmental Health 2017 16:81

    Published on: 28 July 2017

  4. Research

    Impact of phthalate and BPA exposure during in utero windows of susceptibility on reproductive hormones and sexual maturation in peripubertal males

    Phthalates and BPA are endocrine disrupting chemicals (EDCs) widely used in consumer products. Evidence suggests that phthalate and BPA exposure alters steroid hormone levels in adults, while in utero exposure...

    Deborah J. Watkins, Brisa N. Sánchez, Martha Maria Téllez-Rojo, Joyce M. Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E. Peterson and John D. Meeker

    Environmental Health 2017 16:69

    Published on: 21 June 2017

  5. Research

    The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

    Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist du...

    Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas and David J. Robbins

    Environmental Health 2017 16:59

    Published on: 14 June 2017

  6. Research

    Mobile phone use, school electromagnetic field levels and related symptoms: a cross-sectional survey among 2150 high school students in Izmir

    Health outcomes of electromagnetic fields (EMF) from mobile phones and their base stations are of concern. Conducting multidisciplinary research, targeting children and exploring dose-response are recommended....

    Raika Durusoy, Hür Hassoy, Ahmet Özkurt and Ali Osman Karababa

    Environmental Health 2017 16:51

    Published on: 2 June 2017

  7. Research

    Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life

    In utero arsenic exposure may alter fetal developmental programming by altering DNA methylation, which may result in a higher risk of disease in later life. We evaluated the association between in utero arseni...

    Akhilesh Kaushal, Hongmei Zhang, Wilfried J. J. Karmaus, Todd M. Everson, Carmen J. Marsit, Margaret R. Karagas, Shih-Fen Tsai, Hui-Ju Wen and Shu-Li Wang

    Environmental Health 2017 16:50

    Published on: 30 May 2017

  8. Research

    Prenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort study

    Animal models show that prenatal bisphenol A (BPA) exposure leads to sexually dimorphic disruption of the neuroendocrine system in offspring, including the hypothalamic-pituitary-adrenal (HPA) neuroendocrine s...

    Gerald F Giesbrecht, Maede Ejaredar, Jiaying Liu, Jenna Thomas, Nicole Letourneau, Tavis Campbell, Jonathan W Martin and Deborah Dewey

    Environmental Health 2017 16:47

    Published on: 19 May 2017

  9. Research

    Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study

    Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child development. Pesticide exposure determinants need to be studied in order to identify sources and pathways of pestic...

    Sabrina Llop, Mario Murcia, Carmen Iñiguez, Marta Roca, Llúcia González, Vicent Yusà, Marisa Rebagliato and Ferran Ballester

    Environmental Health 2017 16:46

    Published on: 17 May 2017

  10. Research

    Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach

    Ground-level ozone is a potent airway irritant and a determinant of respiratory morbidity. Susceptibility to the health effects of ambient ozone may be influenced by both intrinsic and extrinsic factors, such ...

    Cassandra R. O’ Lenick, Howard H. Chang, Michael R. Kramer, Andrea Winquist, James A. Mulholland, Mariel D. Friberg and Stefanie Ebelt Sarnat

    Environmental Health 2017 16:36

    Published on: 5 April 2017

    The Erratum to this article has been published in Environmental Health 2017 16:63

  11. Research

    Cross-sectional study of social behaviors in preschool children and exposure to flame retardants

    Children are exposed to flame retardants from the built environment. Brominated diphenyl ethers (BDE) and organophosphate-based flame retardants (OPFRs) are associated with poorer neurocognitive functioning in...

    Shannon T. Lipscomb, Megan M. McClelland, Megan MacDonald, Andres Cardenas, Kim A. Anderson and Molly L. Kile

    Environmental Health 2017 16:23

    Published on: 9 March 2017

  12. Research

    Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

    Despite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the associa...

    Eun-Hye Kim, Byoung-Hak Jeon, Jihyun Kim, Young-Min Kim, Youngshin Han, Kangmo Ahn and Hae-Kwan Cheong

    Environmental Health 2017 16:24

    Published on: 9 March 2017

  13. Research

    Early-life exposure to air pollution and greater use of academic support services in childhood: a population-based cohort study of urban children

    There is a growing literature showing associations between prenatal and early-life exposure to air pollution and children’s neurodevelopment. However, it is unclear if decrements in neurodevelopment observed i...

    Jeanette A. Stingone, Katharine H. McVeigh and Luz Claudio

    Environmental Health 2017 16:2

    Published on: 18 January 2017

  14. Research

    Internal living environment and respiratory disease in children: findings from the Growing Up in New Zealand longitudinal child cohort study

    The incidence of early childhood acute respiratory infections (ARIs) has been associated with aspects of the indoor environment. In recent years, public awareness about some of these environmental issues has i...

    Sandar Tin Tin, Alistair Woodward, Rajneeta Saraf, Sarah Berry, Polly Atatoa Carr, Susan M. B. Morton and Cameron C. Grant

    Environmental Health 2016 15:120

    Published on: 8 December 2016

  15. Research

    Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years

    Lead toxicity is of particular public health concern given its near ubiquitous distribution in nature and established neurotoxicant properties. Similar in its ubiquity and ability to inhibit neurodevelopment, ...

    Kelsey M. Gleason, Linda Valeri, A. H. Shankar, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Ema G. Rodrigues, David C. Christiani, Robert O. Wright, David C. Bellinger and Maitreyi Mazumdar

    Environmental Health 2016 15:103

    Published on: 4 November 2016

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