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Children’s Environmental Health

Health effects of early-life exposures to environmental hazards

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  1. Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors in child...

    Authors: William B. Patterson, Jessica Glasson, Noopur Naik, Roshonda B. Jones, Paige K. Berger, Jasmine F. Plows, Hilary A. Minor, Frederick Lurmann, Michael I. Goran and Tanya L. Alderete

    Citation: Environmental Health 2021 20:67

    Content type: Research

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  2. Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of...

    Authors: Chalana M. Sol, Charissa van Zwol - Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande and Susana Santos

    Citation: Environmental Health 2021 20:60

    Content type: Research

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  3. Rice is an important dietary source for methylmercury; however, rice does not contain the same beneficial nutrients as fish. Our main objective was to assess associations of prenatal methylmercury exposure thr...

    Authors: Sarah E. Rothenberg, Susan A. Korrick, Jihong Liu, Yanfen Nong, Hua Nong, Chuan Hong, Eva P. Trinh, Xu Jiang, Fred J. Biasini and Fengxiu Ouyang

    Citation: Environmental Health 2021 20:50

    Content type: Research

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  4. The first 1000 days of life -including pregnancy and the first 2 years after birth- represent a critical window for health interventions.

    Authors: Alessandra Bettiol, Elena Gelain, Erika Milanesio, Federica Asta and Franca Rusconi

    Citation: Environmental Health 2021 20:46

    Content type: Review

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  5. Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize et...

    Authors: Hyunok Choi, Miroslav Dostal, Anna Pastorkova, Pavel Rossner Jr and Radim J. Sram

    Citation: Environmental Health 2021 20:40

    Content type: Research

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  6. Hypothalamic-pituitary-adrenal (HPA)-axis dysfunction has been associated with a variety of mental health and cardio-metabolic disorders. While causal models of HPA-axis dysregulation have been largely focused...

    Authors: C. M. Toledo-Corral, T. L. Alderete, M. M. Herting, R. Habre, A. K. Peterson, F. Lurmann, M. I. Goran, M. J. Weigensberg and F. D. Gilliland

    Citation: Environmental Health 2021 20:39

    Content type: Research

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  7. An unusual feature of SARS-Cov-2 infection and the COVID-19 pandemic is that children are less severely affected than adults. This is especially paradoxical given the epidemiological links between poor air qua...

    Authors: Peter D. Sly, Brittany A. Trottier, Catherine M. Bulka, Stephania A. Cormier, Julius Fobil, Rebecca C. Fry, Kyoung-Woong Kim, Steven Kleeberger, Pushpam Kumar, Philip J. Landrigan, Karin C. Lodrop Carlsen, Antonio Pascale, Fernando Polack, Mathuros Ruchirawat, Heather J. Zar and William A. Suk

    Citation: Environmental Health 2021 20:34

    Content type: Commentary

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  8. Traffic-related air pollution (TRAP) has been associated with increased risk of airway inflammation in children with asthma. While epigenetic changes could potentially modulate TRAP-induced inflammatory respon...

    Authors: N. Ji, M. Fang, A. Baptista, C. Cepeda, M. Greenberg, I. Colon Mincey, P. Ohman-Strickland, F. Haynes, N. Fiedler, H. M. Kipen and R. J. Laumbach

    Citation: Environmental Health 2021 20:12

    Content type: Research

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  9. Child blood pressure (BP) is predictive of future cardiovascular risk. Prenatal exposure to metals has been associated with higher BP in childhood, but most studies have evaluated elements individually and mea...

    Authors: Caitlin G. Howe, Katerina Margetaki, Marina Vafeiadi, Theano Roumeliotaki, Marianna Karachaliou, Manolis Kogevinas, Rob McConnell, Sandrah P. Eckel, David V. Conti, Maria Kippler, Shohreh F. Farzan and Leda Chatzi

    Citation: Environmental Health 2021 20:1

    Content type: Research

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  10. The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methyl...

    Authors: Congrong Wang, Michelle Plusquin, Akram Ghantous, Zdenko Herceg, Rossella Alfano, Bianca Cox and Tim S. Nawrot

    Citation: Environmental Health 2020 19:129

    Content type: Research

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  11. Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the ...

    Authors: Hong Liang, Ziliang Wang, Maohua Miao, Youping Tian, Yan Zhou, Sheng Wen, Yao Chen, Xiaowei Sun and Wei Yuan

    Citation: Environmental Health 2020 19:127

    Content type: Research

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  12. Endocrine disrupting chemicals (EDCs) such as metals have been reported to alter circulating reproductive hormone concentrations and pubertal development in animals. However, the relationship has rarely been i...

    Authors: Pahriya Ashrap, John D. Meeker, Brisa N. Sánchez, Niladri Basu, Marcela Tamayo-Ortiz, Maritsa Solano-González, Adriana Mercado-García, Martha M. Téllez-Rojo, Karen E. Peterson and Deborah J. Watkins

    Citation: Environmental Health 2020 19:124

    Content type: Research

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  13. We thank Sani Rachman Soleman et al. for three specific points of criticism concerning our investigation of the ecological association between low birth weight (LBW) and radioactive contamination in Japan afte...

    Authors: Hagen Scherb and Keiji Hayashi

    Citation: Environmental Health 2020 19:123

    Content type: Letter to the Editor Response

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    The original article was published in Environmental Health 2020 19:121

  14. Childhood exposure to air pollution contributes to cardiovascular disease in adulthood. Immune and oxidative stress disturbances might mediate the effects of air pollution on the cardiovascular system, but the...

    Authors: Mary Prunicki, Nicholas Cauwenberghs, Jennifer Arthur Ataam, Hesam Movassagh, Juyong Brian Kim, Tatiana Kuznetsova, Joseph C. Wu, Holden Maecker, Francois Haddad and Kari Nadeau

    Citation: Environmental Health 2020 19:108

    Content type: Research

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  15. Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biom...

    Authors: Weiwei Liu, Yongjuan Xin, Qianwen Li, Yanna Shang, Zhiguang Ping, Junxia Min, Catherine M. Cahill, Jack T. Rogers and Fudi Wang

    Citation: Environmental Health 2020 19:104

    Content type: Review

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  16. Various risk factors influence obesity differently, and environmental endocrine disruption may increase the occurrence of obesity. However, most of the previous studies have considered only a unitary exposure ...

    Authors: Bangsheng Wu, Yi Jiang, Xiaoqing Jin and Li He

    Citation: Environmental Health 2020 19:94

    Content type: Research

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  17. Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, par...

    Authors: Yann Malaisé, Corinne Lencina, Christel Cartier, Maïwenn Olier, Sandrine Ménard and Laurence Guzylack-Piriou

    Citation: Environmental Health 2020 19:93

    Content type: Research

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  18. A previous study showed that dibutyl phthalate (DBP) exposure disrupted the growth of testicular Sertoli cells (SCs). In the present study, we aimed to investigate the potential mechanism by which DBP promotes...

    Authors: Tan Ma, Jiwei Hou, Yuan Zhou, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han and Dongmei Li

    Citation: Environmental Health 2020 19:87

    Content type: Research

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  19. Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart...

    Authors: Hagen Scherb and Keiji Hayashi

    Citation: Environmental Health 2020 19:82

    Content type: Research

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    The Letter to the Editor to this article has been published in Environmental Health 2020 19:120

    The Letter to the Editor to this article has been published in Environmental Health 2020 19:121

  20. The number of pediatric patients diagnosed with influenza types A and B is increasing annually, especially in temperate regions such as Shanghai (China). The onset of pandemic influenza viruses might be attrib...

    Authors: Yanbo Li, Xiaofang Ye, Ji Zhou, Feng Zhai and Jie Chen

    Citation: Environmental Health 2020 19:71

    Content type: Research

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  21. Concerns about the effects of bisphenol A (BPA) on human brain and behavior are not novel; however, Grohs and colleagues have contributed groundbreaking data on this topic in a recent issue of Environmental Healt...

    Authors: Vicente Mustieles and Mariana F. Fernández

    Citation: Environmental Health 2020 19:66

    Content type: Commentary

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  22. Pesticide exposure during susceptible windows and at certain doses are linked to numerous birth defects. Early experimental evidence suggests an association between active ingredients in pesticides and holopro...

    Authors: Yonit A. Addissie, Paul Kruszka, Angela Troia, Zoë C. Wong, Joshua L. Everson, Beth A. Kozel, Robert J. Lipinski, Kristen M. C. Malecki and Maximilian Muenke

    Citation: Environmental Health 2020 19:65

    Content type: Research

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  23. Organophosphate esters (OPEs) are synthetic chemicals used as flame retardants and plasticizers in a variety of goods. Despite ubiquitous human exposures and laboratory evidence that prenatal OPE exposures may...

    Authors: Jordan R. Kuiper, Heather M. Stapleton, Marsha Wills-Karp, Xiaobin Wang, Irina Burd and Jessie P. Buckley

    Citation: Environmental Health 2020 19:55

    Content type: Research

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  24. Children are exposed to p,p’-dichlorodiphenyltrichloroethane (p,p’-DDT) and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) through placental and lactational transfer. Some studies have suggested that early-life...

    Authors: Laurence Plouffe, Delphine Bosson-Rieutort, Lina Madaniyazi, Miyuki Iwai-Shimada, Kunihiko Nakai, Nozomi Tatsuta, Shoji F. Nakayama and Marc-André Verner

    Citation: Environmental Health 2020 19:49

    Content type: Research

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    The Correction to this article has been published in Environmental Health 2020 19:56

  25. Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and m...

    Authors: Barrett M. Welch, Adam Branscum, G. John Geldhof, Sharia M. Ahmed, Perry Hystad, Ellen Smit, Sakila Afroz, Meghan Megowan, Mostofa Golam, Omar Sharif, Mahmuder Rahman, Quazi Quamruzzaman, David C. Christiani and Molly L. Kile

    Citation: Environmental Health 2020 19:41

    Content type: Research

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  26. Previous studies have shown a correlation between fluoride concentrations in urine and community water fluoride concentrations. However, there are no studies of the relationship between community water fluorid...

    Authors: Dawud Abduweli Uyghurturk, Dana E. Goin, Esperanza Angeles Martinez-Mier, Tracey J. Woodruff and Pamela K. DenBesten

    Citation: Environmental Health 2020 19:38

    Content type: Research

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  27. In light of the vulnerability of the developing brain, mixture risk assessment (MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented, since infants and children are co-exposed to ...

    Authors: Francesca Pistollato, Emilio Mendoza de Gyves, Donatella Carpi, Stephanie K. Bopp, Carolina Nunes, Andrew Worth and Anna Bal-Price

    Citation: Environmental Health 2020 19:23

    Content type: Research

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  28. Prenatal exposure to environmental contaminants can have deleterious effects on child development. While psychomotor, cognitive and behavioural outcomes have been investigated in relation to chronic exposure, ...

    Authors: C. Polevoy, T. E. Arbuckle, Y. Oulhote, B. P. Lanphear, K. A. Cockell, G. Muckle and D. Saint-Amour

    Citation: Environmental Health 2020 19:14

    Content type: Research

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  29. As climate research continues to highlight the global shifts in temperature and precipitation, more research is needed to understand how climate anomalies impact human health outcomes. In this paper, we analyz...

    Authors: Cristina Bradatan, Jeffrey A. Dennis, Nadia Flores-Yeffal and Sharmistha Swain

    Citation: Environmental Health 2020 19:10

    Content type: Research

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  30. Lima is one of the more polluted cities in Latin America. High levels of PM2.5 have been shown to increase health center outpatient visits of respiratory diseases.

    Authors: Jennifer Estefanía Davila Cordova, Vilma Tapia Aguirre, Vanessa Vasquez Apestegui, Luis Ordoñez Ibarguen, Bryan N. Vu, Kyle Steenland and Gustavo F. Gonzales

    Citation: Environmental Health 2020 19:7

    Content type: Research

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    The Correction to this article has been published in Environmental Health 2020 19:11

  31. The associations between indoor environmental quality (IEQ) in homes and symptom reporting of children have been extensively studied, but only few large-scale studies have been done in schools. We examined ass...

    Authors: Kateryna Savelieva, Tero Marttila, Jussi Lampi, Sari Ung-Lanki, Marko Elovainio and Juha Pekkanen

    Citation: Environmental Health 2019 18:115

    Content type: Research

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  32. Recent lead (Pb) exposure reduction strategies enabled to lower children’s blood lead levels (B-Pb) worldwide. This study reports the estimated intelligence gain and social cost savings attributable to recent ...

    Authors: Sylvie Remy, Ramona Hambach, Marc Van Sprundel, Caroline Teughels, Tim S. Nawrot, Jurgen Buekers, Christa Cornelis, Liesbeth Bruckers and Greet Schoeters

    Citation: Environmental Health 2019 18:113

    Content type: Research

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  33. After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public ...

    Authors: Philippe Grandjean

    Citation: Environmental Health 2019 18:110

    Content type: Review

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  34. Increasing evidence suggests that prenatal exposure to arsenic, even at common environmental levels, adversely affects child health. These adverse effects include impaired fetal growth, which can carry serious...

    Authors: Emily F. Winterbottom, Yuguang Ban, Xiaodian Sun, Anthony J. Capobianco, Carmen J. Marsit, Xi Chen, Lily Wang, Margaret R. Karagas and David J. Robbins

    Citation: Environmental Health 2019 18:100

    Content type: Research

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  35. Humans are exposed to mixtures of chemicals across their lifetimes, a concept sometimes called the “exposome.” Mixtures likely have temporal “critical windows” of susceptibility like single agents and measurin...

    Authors: Yuri Levin-Schwartz, Chris Gennings, Lourdes Schnaas, María del Carmen Hernández Chávez, David C. Bellinger, Martha Maria Téllez-Rojo, Andrea A. Baccarelli and Robert O. Wright

    Citation: Environmental Health 2019 18:92

    Content type: Research

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  36. Uncertainty remains regarding the association between blood lead levels (BLL) and serum uric acid (SUA) with relatively low BLL exposure because of limited data in the adolescent population. We examined the as...

    Authors: Guiping Hu, Guang Jia, Shichuan Tang, Pai Zheng and Lihua Hu

    Citation: Environmental Health 2019 18:86

    Content type: Research

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  37. Bisphenol A (BPA) is commonly used in the manufacture of plastics and epoxy resins. In North America, over 90% of the population has detectable levels of urinary BPA. Human epidemiological studies have reporte...

    Authors: Melody N. Grohs, Jess E. Reynolds, Jiaying Liu, Jonathan W. Martin, Tyler Pollock, Catherine Lebel and Deborah Dewey

    Citation: Environmental Health 2019 18:85

    Content type: Research

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  38. Pneumonia, the leading reason underlying childhood deaths, may be triggered or exacerbated by air pollution. To date, only a few studies have examined the association of air pollution with emergency department...

    Authors: Chi-Yung Cheng, Shih-Yu Cheng, Chien-Chih Chen, Hsiu-Yung Pan, Kuan-Han Wu and Fu-Jen Cheng

    Citation: Environmental Health 2019 18:77

    Content type: Research

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  39. Metal exposure is a public health hazard due to neurocognitive effects starting in early life. Poor socio-economic status, adverse home and family environment can enhance the neurodevelopmental toxicity due to...

    Authors: Roberto G. Lucchini, Stefano Guazzetti, Stefano Renzetti, Michele Conversano, Giuseppa Cagna, Chiara Fedrighi, Augusto Giorgino, Marco Peli, Donatella Placidi, Silvia Zoni, Giovanni Forte, Costanza Majorani, Anna Pino, Oreste Senofonte, Francesco Petrucci and Alessandro Alimonti

    Citation: Environmental Health 2019 18:67

    Content type: Research

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  40. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent pollutants and have endocrine disruptive and neurotoxic effects. The association between maternal PFAS concentrations and neuropsychological...

    Authors: Jinbo Niu, Hong Liang, Youping Tian, Wei Yuan, Hong Xiao, Hui Hu, Xiaowei Sun, Xiuxia Song, Sheng Wen, Li Yang, Yanfeng Ren and Maohua Miao

    Citation: Environmental Health 2019 18:53

    Content type: Research

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  41. Growing evidence indicates that in utero arsenic exposures in humans may increase the risk of adverse health effects and development of diseases later in life. This study aimed to evaluate potential health ris...

    Authors: Panida Navasumrit, Krittinee Chaisatra, Jeerawan Promvijit, Varabhorn Parnlob, Somchamai Waraprasit, Chalida Chompoobut, Ta Thi Binh, Doan Ngoc Hai, Nguyen Duy Bao, Nguyen Khac Hai, Kyoung-Woong Kim, Leona D. Samson, Joseph H. Graziano, Chulabhorn Mahidol and Mathuros Ruchirawat

    Citation: Environmental Health 2019 18:51

    Content type: Research

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    The Correction to this article has been published in Environmental Health 2019 18:68

  42. Air pollution has been shown to promote cardiovascular disease in adults. Possible mechanisms include air pollution induced changes in arterial wall function and structure. Atherosclerotic vascular disease is ...

    Authors: Anna-Maria Ntarladima, Ilonca Vaartjes, Diederick E. Grobbee, Martin Dijst, Oliver Schmitz, Cuno Uiterwaal, Geertje Dalmeijer, Cornelis van der Ent, Gerard Hoek and Derek Karssenberg

    Citation: Environmental Health 2019 18:50

    Content type: Research

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  43. Fetal growth restriction (FGR) is not only a major determinant of perinatal morbidity and mortality but also leads to adverse health effects in later life. Over the past decade, numerous studies have indicated...

    Authors: Zhijuan Cao, Lulu Meng, Yan Zhao, Chao Liu, Yingying Yang, Xiujuan Su, Qingyan Fu, Dongfang Wang and Jing Hua

    Citation: Environmental Health 2019 18:49

    Content type: Research

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  44. Previous animal and ecological studies have provided evidence for an earlier sexual maturation in females in relation to fluoride exposure; however, no epidemiological studies have examined the association bet...

    Authors: Yun Liu, Martha Téllez-Rojo, Howard Hu, Brisa N. Sánchez, E. Angeles Martinez-Mier, Niladri Basu, Adriana Mercado-García, Maritsa Solano-González and Karen E. Peterson

    Citation: Environmental Health 2019 18:26

    Content type: Research

    Published on: