Lead toxicity is of particular public health concern given its near ubiquitous distribution in nature and established neurotoxicant properties. Similar in its ubiquity and ability to inhibit neurodevelopment, ...
Authors: Kelsey M. Gleason, Linda Valeri, A. H. Shankar, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Ema G. Rodrigues, David C. Christiani, Robert O. Wright, David C. Bellinger and Maitreyi Mazumdar
Most particulate matter (PM) and health studies in children with asthma use exposures averaged over the course of a day and do not take into account spatial/temporal variability that presumably occurs as child...
Authors: Nathan Rabinovitch, Colby D. Adams, Matthew Strand, Kirsten Koehler and John Volckens
Children with asthma experience increased susceptibility to airborne pollutants. Exposure to traffic and industrial activity have been positively associated with exacerbation of symptoms as well as emergency r...
Authors: Krystal J. Godri Pollitt, Caitlin L. Maikawa, Amanda J. Wheeler, Scott Weichenthal, Nina A. Dobbin, Ling Liu and Mark S. Goldberg
Children’s exposure to manganese (Mn) is a public health concern and consistent policy guidelines for safe levels of Mn exposure is lacking. The complexity of establishing exposure thresholds for Mn partially ...
Authors: Donna J. Coetzee, Patricia M. McGovern, Raghavendra Rao, Lisa J. Harnack, Michael K. Georgieff and Irina Stepanov
Phthalates, used in a variety of consumer products, are a group of chemicals that are ubiquitous in the environment, and their metabolites are detectable in most humans. Some phthalates have anti-androgenic pr...
Authors: Zana Percy, Yingying Xu, Heidi Sucharew, Jane C. Khoury, Antonia M. Calafat, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen and Kimberly Yolton
Ultrafine particles (<100 nm) are ubiquitous present in the air and may contribute to adverse cardiovascular effects. Exposure to air pollutants can alter miRNA expression, which can affect downstream signalin...
Authors: Annette Vriens, Tim S. Nawrot, Nelly D. Saenen, Eline B. Provost, Michal Kicinski, Wouter Lefebvre, Charlotte Vanpoucke, Jan Van Deun, Olivier De Wever, Karen Vrijens, Patrick De Boever and Michelle Plusquin
Temperament is a psychological construct that reflects both personality and an infant’s reaction to social stimuli. It can be assessed early in life and is stable over time Temperament predicts many later life...
Authors: Annemarie Stroustrup, Hsiao-Hsien Hsu, Katherine Svensson, Lourdes Schnaas, Alejandra Cantoral, Maritsa Solano González, Mariana Torres-Calapiz, Chitra Amarasiriwardena, David C. Bellinger, Brent A. Coull, Martha M. Téllez-Rojo, Robert O. Wright and Rosalind J. Wright
Traffic exhaust, refineries and industrial facilities are major sources of air toxics identified by the U.S. Environmental Protection Agency (U.S. EPA) for their potential risk to human health. In utero and ea...
Authors: Elaine Symanski, P. Grace Tee Lewis, Ting-Yu Chen, Wenyaw Chan, Dejian Lai and Xiaomei Ma
In a community in northern Chile, explosive procedures are used by two local industrial mines (gold, copper). We hypothesized that the prevalence of asthma and rhinoconjunctivitis in the community may be assoc...
Authors: Ronald Herrera, Katja Radon, Ondine S. von Ehrenstein, Stella Cifuentes, Daniel Moraga Muñoz and Ursula Berger
Lead is a pervasive neurotoxicant that has been associated with poorer cognitive, behavioral, and motor outcomes in children. The effects of lead on sensory function have not been well characterized. The aim o...
Authors: Monica K. Silver, Xiaoqing Li, Yuhe Liu, Ming Li, Xiaoqin Mai, Niko Kaciroti, Paul Kileny, Twila Tardif, John D. Meeker and Betsy Lozoff
To investigate air pollution effects during pregnancy or in the first weeks of life, models are needed that capture both the spatial and temporal variability of air pollution exposures.
Authors: Elena Proietti, Edgar Delgado-Eckert, Danielle Vienneau, Georgette Stern, Ming-Yi Tsai, Philipp Latzin, Urs Frey and Martin Röösli
Household air pollution (HAP) - predominantly from cooking fuel is a major public health hazard and one of the leading causes of respiratory illness and deaths among children under-five years in India. This st...
Authors: Sabrina Naz, Andrew Page and Kingsley Emwinyore Agho
Bisphenol A (BPA) is a ubiquitous, endocrine-disrupting environmental contaminant that increases risk of some adverse developmental effects. Thus, it is important to characterize BPA levels, metabolic fate and...
Authors: Roy R. Gerona, Janet Pan, Ami R. Zota, Jackie M. Schwartz, Matthew Friesen, Julia A. Taylor, Patricia A. Hunt and Tracey J. Woodruff
Polybrominated diphenyl ethers are known endocrine disrupting environmental contaminants used as flame retardants. Their levels have increased in humans over the last ten years, raising concerns about their co...
Authors: Yasmine K. Serme-Gbedo, Nadia Abdelouahab, Jean-Charles Pasquier, Alan A. Cohen and Larissa Takser
The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associ...
Authors: Ema G. Rodrigues, David C. Bellinger, Linda Valeri, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Mostofa Golam, Molly L. Kile, David C. Christiani, Robert O. Wright and Maitreyi Mazumdar
Cortisol has functions on homeostasis, growth, neurodevelopment, immune function and the stress response. Secretion follows a diurnal rhythm that mediates these processes. Our objective was to examine the asso...
Authors: Marcela Tamayo y Ortiz, Martha María Téllez-Rojo, Rosalind J. Wright, Brent A. Coull and Robert O. Wright
Use of mobile (MP) and cordless phones (CP) is common among young children, but whether the resulting radiofrequency exposure affects development of cognitive skills is not known. Small changes have been found...
Authors: Mary Redmayne, Catherine L. Smith, Geza Benke, Rodney J. Croft, Anna Dalecki, Christina Dimitriadis, Jordy Kaufman, Skye Macleod, Malcolm R. Sim, Rory Wolfe and Michael J. Abramson
Injuries involving career-technical-vocational education (CTE) are reported to the New Jersey Safe Schools Program online reporting system, the only U.S. State law-based surveillance data for young workers (ag...
Authors: Alexsandra A. Apostolico and Derek G. Shendell
Several studies demonstrated a short-term association between ambient temperature and blood pressure. However, few studies have assessed the long-term effect of ambient temperature on children’s blood pressure...
Authors: Qin Li, Yuming Guo, Dong-Mei Wei, Yi Song, Jie-Yun Song, Jun Ma and Hai-Jun Wang
Studies emphasize the importance of particulate matter (PM) in the formation of reactive oxygen species and inflammation. We hypothesized that PM exposure during different time windows in pregnancy influences ...
Authors: Lotte Grevendonk, Bram G. Janssen, Charlotte Vanpoucke, Wouter Lefebvre, Mirjam Hoxha, Valentina Bollati and Tim S. Nawrot
This study assesses the accuracy and comprehensiveness of online public health education materials from the three Australian cities with active lead mines and or smelters: Broken Hill, Mount Isa and Port Pirie.
Blood lead levels have decreased in Mexico since leaded fuel was banned in 1997, but other sources remain, including the use of lead-glazed ceramics for food storage and preparation. Zinc deficiency is present...
Authors: Alejandra Cantoral, Martha M. Téllez-Rojo, Teresa Shamah Levy, Mauricio Hernández-Ávila, Lourdes Schnaas, Howard Hu, Karen E. Peterson and Adrienne S. Ettinger
Perfluoroalkyl acids are synthetic compounds widely used in industrial and commercial applications. Laboratory studies suggest that these persistent and bioaccumulative chemicals produce oxidant stress and dam...
Authors: Anglina Kataria, Howard Trachtman, Laura Malaga-Dieguez and Leonardo Trasande
Pyrethroid pesticides cause abnormalities in the dopamine system and produce an ADHD phenotype in animal models, with effects accentuated in males versus females. However, data regarding behavioral effects of ...
Authors: Melissa Wagner-Schuman, Jason R. Richardson, Peggy Auinger, Joseph M. Braun, Bruce P. Lanphear, Jeffery N. Epstein, Kimberly Yolton and Tanya E. Froehlich
By-products of water disinfectants have been suggested to cause asthma, especially in atopic children. However, studies on indoor swimming pool attendance and asthma in children have presented conflicting resu...
Authors: Martin Andersson, Linnea Hedman, Gunnar Nordberg, Bertil Forsberg, Kåre Eriksson and Eva Rönmark
Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic exp...
Authors: Maitreyi Mazumdar, Md Omar Sharif Ibne Hasan, Rezina Hamid, Linda Valeri, Ligi Paul, Jacob Selhub, Ema G Rodrigues, Fareesa Silva, Selim Mia, Md Golam Mostofa, Quazi Quamruzzaman, Mahmuder Rahman and David C Christiani
Childhood asthma morbidity has been associated with ambient ozone in case-crossover studies. Varying effects of ozone by child age and sex, however, have been less explored.
Authors: Perry Elizabeth Sheffield, Jiang Zhou, Jessie Loving Carr Shmool and Jane Ellen Clougherty
Epidemiological and animal-based studies have suggested that prenatal and postnatal fluoride exposure has adverse effects on neurodevelopment. The aim of this study was to examine the relationship between expo...
While there is evidence that maternal exposure to benzene is associated with spina bifida in offspring, to our knowledge there have been no assessments to evaluate the role of multiple hazardous air pollutants...
Authors: Michael D Swartz, Yi Cai, Wenyaw Chan, Elaine Symanski, Laura E Mitchell, Heather E Danysh, Peter H Langlois and Philip J Lupo
Prenatal and early life neurodevelopment is exquisitely sensitive to insult from environmental exposures. Identifying the effects of environmental toxicants on neurodevelopmental disorders is particularly impo...
Authors: Sharon K Sagiv, Amy E Kalkbrenner and David C Bellinger
In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum con...
Authors: Birgit Bjerre Høyer, Cecilia Høst Ramlau-Hansen, Carsten Obel, Henning Sloth Pedersen, Agnieszka Hernik, Victor Ogniev, Bo AG Jönsson, Christian H Lindh, Lars Rylander, Anna Rignell-Hydbom, Jens Peter Bonde and Gunnar Toft
In Nigeria, approximately 69% of households use solid fuels as their primary source of domestic energy for cooking. These fuels produce high levels of indoor air pollution. This study aimed to determine whethe...
Authors: Osita Kingsley Ezeh, Kingsley Emwinyore Agho, Michael John Dibley, John Joseph Hall and Andrew Nicolas Page
Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limi...
Authors: Marijke de Cock, Michiel R de Boer, Marja Lamoree, Juliette Legler and Margot van de Bor
Births during 1968-1985 at Camp Lejeune were exposed to drinking water contaminated with trichloroethylene (TCE), tetrachloroethylene (PCE), and benzene.
Authors: Perri Zeitz Ruckart, Frank J Bove and Morris Maslia
Some studies have noted an association between maternal occupational exposures to chlorinated solvents and birth defects in offspring, but data are lacking on the potential impact of industrial air emissions o...
Authors: Jean D Brender, Mayura U Shinde, F Benjamin Zhan, Xi Gong and Peter H Langlois
Children younger than 72 months are most at risk of environmental exposure to lead from ingestion through normal mouthing behavior. Young children are more vulnerable to lead poisoning than adults because lead...
Authors: Chinaro Kennedy, Robert Lordo, Marissa Scalia Sucosky, Rona Boehm and Mary Jean Brown
Previous research has shown exposure to air pollution increases the risk of adverse birth outcomes, although the effects of residential proximity to significant industrial point sources are less defined. The o...
Authors: Travis R Porter, Shia T Kent, Wei Su, Heidi M Beck and Julia M Gohlke
Given the relationship between iron metabolism and lead toxicokinetics, we hypothesized that polymorphisms in iron metabolism genes might modify maternal-fetal lead transfer. The objective of this study was to...
Authors: Mateusz P Karwowski, Allan C Just, David C Bellinger, Rebecca Jim, Earl L Hatley, Adrienne S Ettinger, Howard Hu and Robert O Wright
The prevalence of diagnosed autism has increased rapidly over the last several decades among U.S. children. Environmental factors are thought to be driving this increase and a list of the top ten suspected env...
Gas stoves emit pollutants that are respiratory irritants. U.S. children under age 6 who live in homes where gas stoves are used for cooking or heating have an increased risk of asthma, wheeze and reduced lung...
Authors: Molly L Kile, Eric S Coker, Ellen Smit, Daniel Sudakin, John Molitor and Anna K Harding
Manganese is an essential element for human health and development. Previous studies have shown neurotoxic effects in children exposed to higher levels of manganese. Autism Spectrum Disorder (ASD) is a neurode...
Authors: Mohammad H Rahbar, Maureen Samms-Vaughan, Aisha S Dickerson, Katherine A Loveland, Manouchehr Ardjomand-Hessabi, Jan Bressler, Sydonnie Shakespeare-Pellington, Megan L Grove, Deborah A Pearson and Eric Boerwinkle
Low blood lead levels previously thought to pose no health risks may have an adverse impact on the cognitive development of children. This concern has given rise to new regulatory restrictions upon lead metal ...
Authors: Paola Urrestarazu, Germán Villavicencio, Margaret Opazo, José Arbildua, Craig Boreiko, Katrien Delbeke and Patricio H Rodriguez
Biologically plausible mechanisms link traffic-related air pollution to metabolic disorders and potentially to obesity. Here we sought to determine whether traffic density and traffic-related air pollution wer...
Authors: Michael Jerrett, Rob McConnell, Jennifer Wolch, Roger Chang, Claudia Lam, Genevieve Dunton, Frank Gilliland, Fred Lurmann, Talat Islam and Kiros Berhane
The first step in evaluating potential geographic clusters of disease calls for an evaluation of the disease risk comparing the risk in a defined location to the risk in neighboring locations. Environmental ex...
Authors: James A Thompson, Wesley T Bissett and Anne M Sweeney
Humans are exposed to tributyltin (TBT), previously used as an antifouling paint in ships, mainly through fish consumption. As TBT is a known obesogen, we studied the association of placenta TBT and other orga...
Authors: Panu Rantakokko, Katharina M Main, Christine Wohlfart-Veje, Hannu Kiviranta, Riikka Airaksinen, Terttu Vartiainen, Niels E Skakkebæk, Jorma Toppari and Helena E Virtanen
Xenobiotic chemicals with estrogenic activity (EA), such as bisphenol A (BPA), have been reported to have potential adverse health effects in mammals, including humans, especially in fetal and infant stages. C...
Authors: George D Bittner, Chun Z Yang and Matthew A Stoner
Personal exposure studies of air pollution generally use self-reported diaries to capture individuals’ time-activity data. Enhancements in the accuracy, size, memory and battery life of personal Global Positio...
Authors: Elizabeth Nethery, Gary Mallach, Daniel Rainham, Mark S Goldberg and Amanda J Wheeler
In recent studies in Bangladesh and elsewhere, exposure to arsenic (As) via drinking water is negatively associated with performance-related aspects of child intelligence (e.g., Perceptual Reasoning, Working M...
Authors: Gail A Wasserman, Xinhua Liu, Nancy J LoIacono, Jennie Kline, Pam Factor-Litvak, Alexander van Geen, Jacob L Mey, Diane Levy, Richard Abramson, Amy Schwartz and Joseph H Graziano
The environmental contribution to autism spectrum disorders (ASD) is largely unknown, but household pesticides are receiving increased attention. We examined associations between ASD and maternally-reported us...
Authors: Alexander P Keil, Julie L Daniels and Irva Hertz-Picciotto
