Numbers of risk alleles in Phase II genes among the adolescents and the 'elderly'. The dashed line represents the cut-off point between the relatively low (≤ 4) and high (> 4) sum of risk alleles (see methods). Compared to the adolescents there are less "elderly" persons with five to eleven risk alleles in phase II genes (p < 0.001). Moreover, the mean number of risk alleles is significantly lower in the 'elderly' population compared to the adolescent population (P < 0.001). As can be seen from the figure, among the "elderly" the group with 4 at risk alleles counts the most subjects, more then hundred (107), whereas among the adolescents the group with 5 at risk alleles counts the most subjects, almost 90 (88).