Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals

Mortamais, Marion; Chevrier, Cécile; Philippat, Claire; Petit, Claire; Calafat, Antonia M; Ye, Xiaoyun; Silva, Manori J; Brambilla, Christian; Eijkemans, Marinus JC; Charles, Marie-Aline; Cordier, Sylvaine; Slama, Rémy

doi:10.1186/1476-069X-11-29

Environmental Health

Table 3 Adjusted Association Between Log-Transformed Phenol Urinary Concentrations and Sampling Conditions among French Pregnant Women From Eden Cohort, 2002 – 2006 ^a

From: Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals

		2,4-DCP		2,5-DCP		Sum of Parabens		BP3		BPA		TCS
Sampling conditions	n	β	P	β	P	β	P	β	P	β	P	β	P
Hour of sampling	191		0.40 ^f		0.44 ^f		0.04 ^f		0.13 ^f		0.14 ^f		0.36 ^f
> 7.00 AM	36	0		0		0		0		0		0
≥ 7.00 to 7.59 AM	75	0.17	0.51	0.07	0.86	0.02	0.96	− 0.15	0.74	− 0.39	0.05	0.46	0.35
≥ 8.00 to 9.59 AM	59	− 0.14	0.60	− 0.10	0.80	− 0.14	0.79	0.10	0.82	− 0.41	0.04	− 0.29	0.61
After 10.00 AM	21	0.47	0.33	0.82	0.20	1.09	0.12	1.4	0.05	− 0.58	0.04	0.49	0.57
P trend			0.73		0.46		0.42		0.11		0.03		0.95
Continuous ^b		− 0.03	0.65	0.04	0.72	0.07	0.38	0.14	0.31	− 0.07	0.12	− 0.06	0.62
Creatinine (g/l)^c	191	0.33	0.05	0.36	0.14	0.59	0.04	0.82	> 0.01	0.86	> 0.01	0.20	0.53
Gestational age (weeks)	191		0.90 ^f		0.96 ^f		0.52 ^f		0.13 ^f		> 0.01 ^f		0.45 ^f
24-25	25	0		0		0		0		0		0
25-27	87	− 0.04	0.90	− 0.11	0.79	− 0.41	0.28	− 0.32	0.40	− 0.06	0.75	− 0.10	0.87
27-30	79	− 0.12	0.70	− 0.12	0.78	− 0.39	0.33	0.35	0.44	0.37	0.07	− 0.51	0.38
P trend			0.65		0.81		0.48		0.19		> 0.01		0.26
Continuous ^d		− 0.08	0.29	− 0.08	0.49	− 0.09	0.41	0.15	0.27	0.14	0.01	− 0.17	0.24
Day of sampling	191		0.51 ^f		0.49 ^f		0.86 ^f		0.79 ^f		0.91 ^f		0.76 ^f
Monday	28	0		0		0		0		0		0
Tuesday	54	0.52	0.15	0.82	0.10	0.32	0.48	0.17	0.74	− 0.15	0.42	0.41	0.47
Wednesday	54	0.23	0.46	0.38	0.35	− 0.03	0.95	0.45	0.41	− 0.03	0.87	0.66	0.24
Thursday	31	0.40	0.27	0.58	0.26	0.32	0.57	0.27	0.69	− 0.14	0.49	0.38	0.52
Friday	24	0.05	0.90	0.21	0.69	0.19	0.68	− 0.12	0.82	− 0.09	0.64	0.08	0.90
Season of sampling	191		0.65 ^f		0.28 ^f		0.64 ^f		0.45 ^f		0.35 ^f		0.93 ^f
Jan-March	59	0		0		0		0		0		0
April-June	49	− 0.15	0.55	− 0.46	0.23	− 0.48	0.20	− 0.63	0.15	− 0.10	0.46	− 0.25	0.59
July-Sept	38	− 0.35	0.24	− 0.74	0.11	− 0.12	0.79	0.14	0.77	0.11	0.56	− 0.03	0.96
Oct-Dec	45	− 0.05	0.86	− 0.03	0.93	− 0.22	0.60	− 0.31	0.48	0.25	0.19	− 0.27	0.62
Duration of urine storage at room temperature (hours)	191		0.22 ^f		0.04 ^f		0.29 ^f		0.54 ^f		0.42 ^f		0.33 ^f
> 3	57	0		0		0		0		0		0
3-4	51	− 0.33	0.24	− 0.71	0.09	0.67	0.13	− 0.17	0.67	0.03	0.87	− 0.16	0.74
4-5	32	0.14	0.72	0.23	0.70	0.15	0.78	− 0.62	0.21	0.23	0.28	− 1.1	0.12
> 5	51	− 0.10	0.81	− 0.31	0.58	− 0.09	0.88	− 0.07	0.91	0.27	0.19	− 0.20	0.75
P trend			0.91		0.71		0.70		0.94		0.16		0.78
Continuous ^e		− 0.07	0.18	− 0.12	0.07	− 0.01	0.84	0.02	0.83	0.05	0.06	− 0.02	0.86

^a Linear regression models were corrected for over-representation of cases and adjusted for maternal age, bmi, parity, centre, education, occupation at the time of urine collection and urine sampling conditions.
^b Regression parameters are given for an increase by 1 in the sampling hour.
^c Regression parameters are given for an increase by 1 g/l in urinary creatinine concentration.
^d Regression parameters are given for an increase by 1 week.
^e Regression parameters are given for an increase by 1 hour.
^f P of heterogeneity test

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ISSN: 1476-069X

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