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Table 3 Adjusted Association Between Log-Transformed Phenol Urinary Concentrations and Sampling Conditions among French Pregnant Women From Eden Cohort, 2002 – 2006 a

From: Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals

   2,4-DCP 2,5-DCP Sum of Parabens BP3 BPA TCS
Sampling conditions n β P β P β P β P β P β P
Hour of sampling 191   0.40 f   0.44 f   0.04 f   0.13 f   0.14 f   0.36 f
  > 7.00 AM 36 0   0   0   0   0   0  
  ≥ 7.00 to 7.59 AM 75 0.17 0.51 0.07 0.86 0.02 0.96 − 0.15 0.74 − 0.39 0.05 0.46 0.35
  ≥ 8.00 to 9.59 AM 59 − 0.14 0.60 − 0.10 0.80 − 0.14 0.79 0.10 0.82 − 0.41 0.04 − 0.29 0.61
  After 10.00 AM 21 0.47 0.33 0.82 0.20 1.09 0.12 1.4 0.05 − 0.58 0.04 0.49 0.57
  P trend    0.73   0.46   0.42   0.11   0.03   0.95
  Continuous b   − 0.03 0.65 0.04 0.72 0.07 0.38 0.14 0.31 − 0.07 0.12 − 0.06 0.62
Creatinine (g/l)c 191 0.33 0.05 0.36 0.14 0.59 0.04 0.82 > 0.01 0.86 > 0.01 0.20 0.53
Gestational age (weeks) 191   0.90 f   0.96 f   0.52 f   0.13 f   > 0.01 f   0.45 f
  24-25 25 0   0   0   0   0   0  
  25-27 87 − 0.04 0.90 − 0.11 0.79 − 0.41 0.28 − 0.32 0.40 − 0.06 0.75 − 0.10 0.87
  27-30 79 − 0.12 0.70 − 0.12 0.78 − 0.39 0.33 0.35 0.44 0.37 0.07 − 0.51 0.38
  P trend    0.65   0.81   0.48   0.19   > 0.01   0.26
  Continuous d   − 0.08 0.29 − 0.08 0.49 − 0.09 0.41 0.15 0.27 0.14 0.01 − 0.17 0.24
Day of sampling 191   0.51 f   0.49 f   0.86 f   0.79 f   0.91 f   0.76 f
  Monday 28 0   0   0   0   0   0  
  Tuesday 54 0.52 0.15 0.82 0.10 0.32 0.48 0.17 0.74 − 0.15 0.42 0.41 0.47
  Wednesday 54 0.23 0.46 0.38 0.35 − 0.03 0.95 0.45 0.41 − 0.03 0.87 0.66 0.24
  Thursday 31 0.40 0.27 0.58 0.26 0.32 0.57 0.27 0.69 − 0.14 0.49 0.38 0.52
  Friday 24 0.05 0.90 0.21 0.69 0.19 0.68 − 0.12 0.82 − 0.09 0.64 0.08 0.90
Season of sampling 191   0.65 f   0.28 f   0.64 f   0.45 f   0.35 f   0.93 f
  Jan-March 59 0   0   0   0   0   0  
  April-June 49 − 0.15 0.55 − 0.46 0.23 − 0.48 0.20 − 0.63 0.15 − 0.10 0.46 − 0.25 0.59
  July-Sept 38 − 0.35 0.24 − 0.74 0.11 − 0.12 0.79 0.14 0.77 0.11 0.56 − 0.03 0.96
  Oct-Dec 45 − 0.05 0.86 − 0.03 0.93 − 0.22 0.60 − 0.31 0.48 0.25 0.19 − 0.27 0.62
Duration of urine storage at room temperature (hours) 191   0.22 f   0.04 f   0.29 f   0.54 f   0.42 f   0.33 f
  > 3 57 0   0   0   0   0   0  
  3-4 51 − 0.33 0.24 − 0.71 0.09 0.67 0.13 − 0.17 0.67 0.03 0.87 − 0.16 0.74
  4-5 32 0.14 0.72 0.23 0.70 0.15 0.78 − 0.62 0.21 0.23 0.28 − 1.1 0.12
  > 5 51 − 0.10 0.81 − 0.31 0.58 − 0.09 0.88 − 0.07 0.91 0.27 0.19 − 0.20 0.75
  P trend    0.91   0.71   0.70   0.94   0.16   0.78
  Continuous e   − 0.07 0.18 − 0.12 0.07 − 0.01 0.84 0.02 0.83 0.05 0.06 − 0.02 0.86
  1. a Linear regression models were corrected for over-representation of cases and adjusted for maternal age, bmi, parity, centre, education, occupation at the time of urine collection and urine sampling conditions.
  2. b Regression parameters are given for an increase by 1 in the sampling hour.
  3. c Regression parameters are given for an increase by 1 g/l in urinary creatinine concentration.
  4. d Regression parameters are given for an increase by 1 week.
  5. e Regression parameters are given for an increase by 1 hour.
  6. f P of heterogeneity test