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Table 5 Odds of bladder cancer associated with GSTO-1 and MTHFR SNPs and arsenic from drinking water†

From: Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case–control study

SNP

Major allele homozygote

Minor allele carrier

 
 

Cases n (%)

Controls n (%)

Age and smoking adjusted OR (95% CI)

Cases n (%)

Controls n (%)

Age and smoking adjusted OR (95% CI)

p-interaction

GSTO-1

       

rs4925

       

Q1

29 (29.9)

31 (25.2)

1.00

29 (25.2)

37 (25.9)

1.00

 

Q2

22 (22.7)

34 (27.6)

0.71 (0.33 – 1.54)

28 (24.3)

34 (23.8)

1.00 (0.49 – 2.05)

 

Q3

23 (23.7)

34 (27.6)

0.71 (0.33 – 1.52)

26 (22.6)

30 (21.0)

1.12 (0.53 – 2.34)

 

Q4

23 (23.7)

24 (19.5)

1.23 (0.55 – 2.76)

32 (27.8)

42 (29.4)

0.90 (0.45 – 1.80)

 

Continuous

97 (44.1)

123 (55.9)

1.10 (1.02 – 1.18)

115 (44.6)

143 (55.4)

1.00 (0.96 – 1.03)

0.03

rs2282326

       

Q1

27 (32.1)

22 (21.2)

1.00

32 (24.4)

46 (27.7)

1.00

 

Q2

21 (25.0)

30 (28.8)

0.63 (0.28 – 1.44)

32 (24.4)

39 (23.5)

1.08 (0.55 – 2.11)

 

Q3

18 (21.4)

29 (27.9)

0.49 (0.21 – 1.13)

30 (22.9)

38 (22.9)

1.17 (0.59 – 2.32)

 

Q4

18 (21.4)

23 (22.1)

0.76 (0.32 – 1.84)

37 (28.2)

43 (25.9)

1.13 (0.59 – 2.17)

 

Continuous

84 (44.7)

104 (55.3)

1.06 (0.99 – 1.14)

131 (44.1)

166 (55.9)

1.01 (0.97 – 1.04)

0.21

MTHFR

       

rs1801131

       

Q1

27 (28.4)

34 (26.8)

1.00

34 (27.6)

34 (23.4)

1.00

 

Q2

23 (24.2)

42 (33.1)

0.68 (0.32 – 1.42)

30 (24.4)

27 (18.6)

1.07 (0.51 – 2.24)

 

Q3

23 (24.2)

25 (19.7)

1.04 (0.48 – 2.27)

26 (21.1)

43 (29.7)

0.64 (0.32 – 1.30)

 

Q4

22 (23.2)

26 (20.5)

1.00 (0.46 – 2.20)

33 (26.8)

41 (28.3)

0.86 (0.43 – 1.72)

 

Continuous

95 (42.8)

127 (57.2)

1.01 (0.96 – 1.05)

123 (45.9)

145 (54.1)

1.03 (0.99-1.08)

0.43

rs1801133

       

Q1

26 (28.3)

29 (24.0)

1.00

35 (27.6)

39 (25.7)

1.00

 

Q2

25 (27.2)

28 (23.1)

1.03 (0.47 – 2.22)

29 (22.8)

41 (27.0)

0.70 (0.35 – 1.41)

 

Q3

19 (20.7)

36 (29.8)

0.65 (0.30 – 1.42)

30 (23.6)

32 (21.1)

0.89 (0.44 – 1.81)

 

Q4

22 (23.9)

28 (23.1)

0.92 (0.42 – 2.02)

33 (26.0)

40 (26.3)

0.85 (0.43 – 1.69)

 

Continuous

92 (43.2)

121 (56.8)

1.07 (1.00 – 1.14)

127 (45.5)

152 (54.5)

0.99 (0.96 – 1.03)

0.05

rs6541003

       

Q1

17 (24.6)

22 (24.7)

1.00

44 (29.5)

45 (24.7)

1.00

 

Q2

16 (23.2)

29 (32.6)

0.72 (0.29 – 1.79)

37 (24.8)

40 (22.0)

0.89 (0.47 – 1.67)

 

Q3

18 (26.1)

19 (21.3)

1.06 (0.42 – 2.69)

31 (20.8)

49 (26.9)

0.68 (0.36 – 1.28)

 

Q4

18 (26.1)

19 (21.3)

1.20 (0.47 – 3.04)

37 (24.8)

48 (26.4)

0.80 (0.43 – 1.49)

 

Continuous

69 (43.7)

89 (56.3)

1.01 (0.96 – 1.05)

149 (45.0)

182 (55.0)

1.03 (0.98 – 1.08)

0.52

rs9651118

       

Q1

37 (26.8)

45 (25.0)

1.00

24 (29.6)

23 (24.7)

1.00

 

Q2

37 (26.8)

46 (25.6)

0.90 (0.48 – 1.70)

17 (21.0)

23 (24.7)

0.73 (0.30 – 1.77)

 

Q3

32 (23.2)

42 (23.3)

0.88 (0.46 – 1.69)

17 (21.0)

26 (28.0)

0.66 (0.28 – 1.57)

 

Q4

32 (23.2)

47 (26.1)

0.84 (0.44 – 1.60)

23 (28.4)

21 (22.6)

1.01 (0.43 – 2.38)

 

Continuous

138 (43.4)

180 (56.6)

1.01 (0.97 – 1.06)

81 (46.6)

93 (53.5)

1.02 (0.97 – 1.08)

0.73

rs4846048

       

Q1

25 (24.5)

31 (23.7)

1.00

36 (31.3)

37 (26.2)

1.00

 

Q2

23 (22.5)

37 (28.2)

0.74 (0.34 – 1.59)

29 (25.2)

32 (22.7)

0.91 (0.45 – 1.84)

 

Q3

25 (24.5)

29 (22.1)

0.88 (0.41 – 1.93)

24 (20.9)

39 (27.7)

0.73 (0.36 – 1.49)

 

Q4

29 (28.4)

34 (26.0)

0.97 (0.46 – 2.05)

26 (22.6)

33 (23.4)

0.89 (0.44 – 1.83)

 

Continuous

102 (43.8)

131 (56.2)

1.01 (0.97 – 1.06)

115 (44.9)

141 (55.1)

1.03 (0.97 – 1.09)

0.65

rs1476413

       

Q1

30 (25.0)

32 (23.0)

1.00

31 (31.6)

35 (26.5)

1.00

 

Q2

29 (24.2)

46 (33.1)

0.66 (0.33 – 1.34)

24 (24.5)

23 (17.4)

1.14 (0.52 – 2.52)

 

Q3

32 (26.7)

27 (19.4)

1.20 (0.58 – 2.51)

17 (17.3)

41 (31.1)

0.48 (0.22 – 1.04)

 

Q4

29 (24.2)

34 (24.5)

0.87 (0.42 – 1.80)

26 (26.5)

33 (25.0)

0.96 (0.46 – 2.01)

 

Continuous

120 (46.3)

139 (53.7)

1.02 (0.98 – 1.06)

98 (42.6)

132 (57.4)

1.02 (0.96 – 1.09)

0.93

  1. † Quartile distribution of average arsenic exposure for among all genotyped participants.
  2. Q1 = 1st quartile (< 0.55 μg/L).
  3. Q2 = 2nd quartile (0.55-1.45 μg/L).
  4. Q3 = 3rd quartile (1.45-3.72 μg/L).
  5. Q4 = 4th quartile (>3.72 μg/L).
  6. ‡ Odds Ratio per one unit increase in the continuous measure of lifetime arsenic exposure by genotype adjusted for age and smoking history (ever/never).
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Environmental Health

ISSN: 1476-069X