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Table 2 Benchmark results for postnatal PFC exposure (in terms of serum concentrations in ng/mL measured at 5 years) with vaccine antibody concentrations at 7 years as the outcomes

From: Immunotoxicity of perfluorinated alkylates: calculation of benchmark doses based on serum concentrations in children

    BMR = 5% BMR = 10% Fit (−2log(L))
Outcome Exposure Model* BMD BMDL BMD BMDL Full scale Low dose
Tetanus PFOS Linear 2.70 1.31 5.55 2.69 1719.81 313.78
   Log 0.13 0.07 0.29 0.14 1719.30 313.75
   Piecewise 1.45 0.56 2.98 1.16 1719.54 313.54
  PFOA Linear 0.38 0.25 0.77 0.51 1712.43 391.53
   Log 0.07 0.04 0.14 0.09 1712.88 391.63
   Piecewise 0.52 0.16 1.07 0.34 1712.33 391.64
Diphtheria PFOS Linear 2.30 1.25 4.72 2.57 1656.86 314.00
   Log 0.11 0.06 0.24 0.13 1655.96 313.38
   Piecewise 0.98 0.49 2.01 1.01 1655.77 313.10
  PFOA Linear 0.59 0.33 1.21 0.68 1656.15 362.37
   Log 0.10 0.06 0.22 0.12 1656.14 362.39
   Piecewise 0.48 0.17 0.99 0.34 1656.12 362.30
  1. *K-power model was identical to the linear model.