Skip to main content

Table 4 Infertility odds ratios according to female serum concentrations of PFAS

From: Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine

  N   PFOA   PFOS PFHxS   PFNA
Greenland   n OR (95% CI) n OR (95% CI) n OR (95% CI) n OR (95% CI)
 Low 150 18 1 (Reference) 14 1 (Reference) 20 1 (Reference) 12 1 (Reference)
 Medium 149 22 1.30 (0.66, 2.54) 23 1.73 (0.85, 3.49) 18 0.90 (0.45, 1.76) 23 1.95 (0.95, 3.99)
 High 149 22 1.57 (0.76, 3.25) 25 1.82 (0.90, 3.67) 24 1.22 (0.64, 2.36) 27 2.15 (1.05, 4.42)
Continuous log-scale 448 62 1.20 (0.61, 2.37) 62 1.74 (0.97, 3.13) 62 0.99 (0.59, 1.65) 62 1.97 (1.22, 3.19)
Poland          
 Low 68 10 1 (Reference) 7 1 (Reference) 10 1 (Reference) 13 1 (Reference)
 Medium 68 12 1.25 (0.50, 3.13) 13 1.93 (0.72, 5.18) 13 1.52 (0.60, 3.84) 11 0.92 (0.38, 2.22)
 High 67 11 1.41 (0.55, 3.61) 13 1.92 (0.72, 5.14) 10 1.07 (0.41, 2.80) 9 0.65 (0.26, 1.66)
Continuous log-scale 203 33 1.11 (0.44, 2.80) 33 2.06 (0.69, 6.12) 33 1.05 (0.50, 2.20) 33 0.74 (0.32, 1.72)
Ukraine          
 Low 96 19 1 (Reference) 18 1 (Reference) 17 1 (Reference) 16 1 (Reference)
 Medium 96 16 0.66 (0.30, 1.45) 20 1.51 (0.70, 3.26) 26 1.37 (0.66, 2.85) 22 1.39 (0.65, 2.97)
 High 95 23 1.21 (0.57, 2.58) 20 1.22 (0.56, 2.65) 15 0.61 (0.27, 1.38) 20 1.17 (0.54, 2.53)
 Continuous log-scale 287 58 0.79 (0.40, 1.54) 58 0.77 (0.41, 1.43) 58 0.76 (0.47, 1.24) 58 1.26 (0.66, 2.40)
Pooled sample          
Continuous log-scale 938 153 1.11 (0.74, 1.66) 153 1.39 (0.93, 2.07) 153 0.99 (0.73, 1.33) 153 1.53 (1.08, 2.15)
  1. CI confidence intervals, N number of women, OR odds ratio, PFAS perfluoroalkyl substances.
  2. The OR analyses are adjusted for parity, gestational week of blood sampling, smoking status, maternal age and BMI.
  3. In addition the pooled analysis is adjusted for country.
  4. FRs are presented in country-specific tertiles and according to a continuous logarithm-transformed scale.