Table 2 Definitions for ‘adverse effect’ and their origins
From: A path forward in the debate over health impacts of endocrine disrupting chemicals
Origin | Definition | Reference |
|---|---|---|
US EPA | “a biochemical change, functional impairment, or pathologic lesion that affects the performance of the whole organism, or reduces an organism’s ability to respond to an additional environmental challenge” | [30] |
IPCS/OECD | “a change in morphology, physiology, growth, development or lifespan of an organism which results in impairment of functional capacity or impairment of capacity to compensate for additional stress or increase in susceptibility to the harmful effects of other environmental influences” | [28] |
US FDA | none | |
EFSA | none | |
Nohynek et al. | “toxicity, i.e. pathology or functional impairment” | [14] |