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Table 3 Logistic regression stratified by menopause status for relationship between polymorphisms and the risk of female breast cancer in Inuit

From: Polymorphisms in Phase I and Phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case–control study in Inuit women

Variables (Ca/Co) N Premenopause p n Postmenopause p
OR* 95% CI (Ca/Co) N OR* 95% CI
CYP1A1 (Ile/Ile vs Ile/Val + Val/Val) 2/17 vs 14/25 5.18 1.01 26.5 0.048 2/15 vs 12/56 1.47 0.28 7.65 0.65
CYP1B1 (leu/Leu vs Leu/Val + Val/Val) 16/28 vs 1/13 0.12 0.013 1.00 0.050 10/52 vs 4/19 1.56 0.40 6.09 0.52
COMT (Val/Val vs Val/Met + Met/Met) 3/8 vs 14/34 1.19 0.27 5.28 0.82 4/11 vs 10/60 0.53 0.13 2.20 0.38
CYP17 (A1/A1 vs A1/A2 + A2/A2) 7/11 vs 9/31 0.42 0.12 1.43 0.16 5/12 vs 9/57 0.47 0.12 1.85 0.28
CYP19 (C > T) (CC vs CT + TT) 13/31 vs 4/11 0.79 0.21 3.04 0.74 10/48 vs 4/24 0.94 0.24 3.60 0.93
CYP19 (TTTA)n (F/F vs F/S + S/S)# 14/33 vs 3/7 0.95 0.21 4.27 0.94 13/43 vs 1/18 0.21 0.025 1.79 0.15
  1. Ca: case, Co: control.
  2. *Adjusted for age but not cotinine because of small sample size.
  3. #F: 7–10 TTTA repeats; S: 11–13 TTTA repeats.
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Environmental Health

ISSN: 1476-069X