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Table 3 Logistic regression stratified by menopause status for relationship between polymorphisms and the risk of female breast cancer in Inuit
| Variables | (Ca/Co) N | Premenopause | p | n | Postmenopause | p | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR* | 95% CI | (Ca/Co) N | OR* | 95% CI | ||||||
| CYP1A1 (Ile/Ile vs Ile/Val + Val/Val) | 2/17 vs 14/25 | 5.18 | 1.01 | 26.5 | 0.048 | 2/15 vs 12/56 | 1.47 | 0.28 | 7.65 | 0.65 |
| CYP1B1 (leu/Leu vs Leu/Val + Val/Val) | 16/28 vs 1/13 | 0.12 | 0.013 | 1.00 | 0.050 | 10/52 vs 4/19 | 1.56 | 0.40 | 6.09 | 0.52 |
| COMT (Val/Val vs Val/Met + Met/Met) | 3/8 vs 14/34 | 1.19 | 0.27 | 5.28 | 0.82 | 4/11 vs 10/60 | 0.53 | 0.13 | 2.20 | 0.38 |
| CYP17 (A1/A1 vs A1/A2 + A2/A2) | 7/11 vs 9/31 | 0.42 | 0.12 | 1.43 | 0.16 | 5/12 vs 9/57 | 0.47 | 0.12 | 1.85 | 0.28 |
| CYP19 (C > T) (CC vs CT + TT) | 13/31 vs 4/11 | 0.79 | 0.21 | 3.04 | 0.74 | 10/48 vs 4/24 | 0.94 | 0.24 | 3.60 | 0.93 |
| CYP19 (TTTA)n (F/F vs F/S + S/S)# | 14/33 vs 3/7 | 0.95 | 0.21 | 4.27 | 0.94 | 13/43 vs 1/18 | 0.21 | 0.025 | 1.79 | 0.15 |
