Table 1 Samples and integration of analytical methods for chemical oriented instrumental measurement
From: Pooling samples for “top-down” molecular exposomics research: the methodology
Sample types | Urinary matrix | Blood matrix | |||||||
|---|---|---|---|---|---|---|---|---|---|
Species | Free form | Conjugated form | Protein conjugated form | Free POPs | |||||
Pollutant | Metal or metalloid | Mercapturic acid | Glucuronic acid | Sulfate | Acetyl | Metal or metalloid | HSA-Cys34 | Lipophilic POPs | Perfluorinated compounds |
Techniques | ICP-MS | UPLC-HRMS(CNL MS/MS) | ICP-MS | UPLC-HRMS(SRM MS/MS) | GC-SIM-MS | LC-MS/MS | |||
Analysis approach | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |