Figure 4From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessmentMechanism of the NMDR relationship phenomenon induced by one of the “metabolic effect” hypotheses. At low concentrations, EDC is catabolized into active metabolites that induce the observed effect. At high concentrations, the metabolic system is saturated, and the parent substance induces an opposite effect, resulting in an NMDR relationship. Note: Mtb = metabolite; xe = xenobiotic (e.g., EDC).Back to article page