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Figure 4 | Environmental Health

Figure 4

From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Figure 4

Mechanism of the NMDR relationship phenomenon induced by one of the “metabolic effect” hypotheses. At low concentrations, EDC is catabolized into active metabolites that induce the observed effect. At high concentrations, the metabolic system is saturated, and the parent substance induces an opposite effect, resulting in an NMDR relationship. Note: Mtb = metabolite; xe = xenobiotic (e.g., EDC).

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