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Table 1 Summary of criteria of analysis with assigned point values used in the evaluation of statistical plausibility of an NMDR relationship

From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Number of doses below ZEP (excluding the control) Score A
1 1
2 2
3 3
4 4
≥5 5
Experimental determination of ZEP Score B
Yes 1
No 0
Number of doses statistically different from control Score C
1 2
2 4
3 8
≥4 16
Reproducibility of the dose-response relationship Score D
Yes 3
No 0
Magnitude of response (percentage control value) Score E a
Inverted-U curve U curve  
≥100%, ≤125% ≤97%, ≥92% 0,5
>125%, ≤150% <92%, ≥84% 1
>150%, ≤200% <84%, ≥68% 2
>200%, ≤400% <68%, ≥5% 3
>400% <5% 4
  1. aThe point value is multiplied by the number of experimental doses falling within the corresponding percentage range.
  2. Criteria reported (Table 1) were extracted from Calabrese and Baldwin [12]. The ZEP (zero equivalent point) corresponds to the point where the response crosses the control value in a hormetic effect.