Table 1 Summary of criteria of analysis with assigned point values used in the evaluation of statistical plausibility of an NMDR relationship

1

1

2

2

3

3

4

4

≥5

5

Experimental determination of ZEP

Score B

Yes

1

No

0

Number of doses statistically different from control

Score C

1

2

2

4

3

8

≥4

16

Reproducibility of the dose-response relationship

Score D

Yes

3

No

0

Magnitude of response (percentage control value)

Score E ^a

Inverted-U curve

U curve

≥100%, ≤125%

≤97%, ≥92%

0,5

>125%, ≤150%

<92%, ≥84%

1

>150%, ≤200%

<84%, ≥68%

2

>200%, ≤400%

<68%, ≥5%

3

>400%

<5%

4