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Table 2 HRs (95% CIs) for breast cancer incidence (n = 5,676) by quintile of estimated exposure for individual mammary gland carcinogenic compounds and summary MGC variable

From: Hazardous air pollutants and breast cancer risk in California teachers: a cohort study

 

Quintile of concentration

 

Compound

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P trend

Acrylamide

1 (Referent)

—a

1.02 (0.94, 1.10)

1.09 (1.02, 1.17)

1.08 (1.01, 1.16)

0.008

Acrylonitrile

1 (Referent)

1.03 (0.95, 1.12)

1.02 (0.94, 1.11)

1.05 (0.97, 1.14)

1.06 (0.97, 1.15)

0.17

Benzene

1 (Referent)

1.09 (1.00, 1.18)

1.03 (0.95, 1.12)

1.03 (0.95, 1.12)

1.06 (0.98, 1.16)

0.38

Benzidine

1 (Referent)

—a

0.98 (0.86, 1.12)

0.97 (0.91, 1.04)

1.06 (0.99, 1.14)

0.24

1,3-Butadiene

1 (Referent)

0.98 (0.91, 1.07)

1.06 (0.98, 1.15)

0.99 (0.91, 1.08)

1.02 (0.94, 1.11)

0.56

Carbon tetrachloride

1 (Referent)

0.98 (0.90, 1.07)

1.04 (0.96, 1.13)

1.03 (0.95, 1.12)

1.08 (1.00, 1.18)

0.03

Chloroprene

1 (Referent)

—a

—a

1.05 (0.96, 1.15)

1.07 (1.00, 1.14)

0.04

1,4-Dioxane

1 (Referent)

1.04 (0.96, 1.13)

1.05 (0.96, 1.14)

1.07 (0.99, 1.16)

1.02 (0.94, 1.11)

0.23

Ethyl carbamate

1 (Referent)

—a

—a

0.97 (0.90, 1.05)

1.07 (1.00, 1.14)

0.22

Ethylene dibromide

1 (Referent)

1.05 (0.97, 1.14)

1.07 (0.99, 1.16)

1.03 (0.95, 1.12)

1.01 (0.93, 1.10)

0.88

Ethylene dichloride

1 (Referent)

1.04 (0.95, 1.12)

0.94 (0.86, 1.02)

1.04 (0.96, 1.13)

1.05 (0.97, 1.14)

0.25

Ethylene oxide

1 (Referent)

0.93 (0.85, 1.00)

0.92 (0.85, 1.00)

0.97 (0.89, 1.05)

1.00 (0.92, 1.08)

0.70

Ethylidene dichloride

1 (Referent)

1.01 (0.93, 1.10)

1.09 (1.00, 1.18)

1.08 (0.99, 1.17)

1.02 (0.94, 1.11)

0.19

Hydrazine

1 (Referent)

—a

0.92 (0.86, 0.99)

0.98 (0.91, 1.06)

1.04 (0.97, 1.12)

0.36

Methylene chloride

1 (Referent)

0.97 (0.89, 1.05)

1.06 (0.98, 1.15)

1.01 (0.93, 1.10)

1.04 (0.96, 1.13)

0.21

4,4'-Methylene bis(2-chloroaniline)

1 (Referent)

—a

—a

1.02 (0.92, 1.13)

1.07 (1.01, 1.15)

0.03

Nitrobenzene

1 (Referent)

—a

—a

1.04 (0.97, 1.12)

1.03 (0.96, 1.10)

0.29

Propylene dichloride

1 (Referent)

1.00 (0.92, 1.08)

0.92 (0.85, 1.01)

1.01 (0.93, 1.09)

1.04 (0.96, 1.13)

0.20

Propylene oxide

1 (Referent)

1.05 (0.97, 1.15)

1.11 (1.02, 1.20)*

1.05 (0.97, 1.14)

1.01 (0.93, 1.10)

0.18

Styrene

1 (Referent)

1.04 (0.96, 1.13)

1.02 (0.94, 1.11)

1.05 (0.96, 1.14)

1.04 (0.96, 1.13)

0.41

2,4-Toluene diisocyanate

1 (Referent)

1.05 (0.96, 1.14)

1.04 (0.96, 1.13)

1.03 (0.95, 1.12)

1.07 (0.98, 1.16)

0.17

o-Toluidine

1 (Referent)

—a

—a

1.10 (1.01, 1.21)

1.03 (0.97, 1.10)

0.10

Vinyl chloride

1 (Referent)

1.03 (0.94, 1.12)

1.12 (1.03, 1.21)*

1.07 (0.99, 1.17)

1.06 (0.98, 1.16)

0.06

Vinylidene chloride

1 (Referent)

0.97 (0.90, 1.06)

0.98 (0.90, 1.07)

1.04 (0.96, 1.13)

1.03 (0.94, 1.11)

0.27

Summary variable

1 (Referent)

0.98 (0.90, 1.07)

0.97 (0.89, 1.05)

1.02 (0.94, 1.10)

1.05 (0.96, 1.14)

0.11

  1. Models stratified by age and adjusted for race. Quintiles based on distribution of all study participants.
  2. aQuintiles combines when a larger portion of the study participants had same concentration value.
  3. *Remains statistically significant (p < 0.05) after adjustment for multiple comparisons.
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Environmental Health

ISSN: 1476-069X