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Table 2 HRs (95% CIs) for breast cancer incidence (n = 5,676) by quintile of estimated exposure for individual mammary gland carcinogenic compounds and summary MGC variable

From: Hazardous air pollutants and breast cancer risk in California teachers: a cohort study

  Quintile of concentration  
Compound Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 P trend
Acrylamide 1 (Referent) a 1.02 (0.94, 1.10) 1.09 (1.02, 1.17) 1.08 (1.01, 1.16) 0.008
Acrylonitrile 1 (Referent) 1.03 (0.95, 1.12) 1.02 (0.94, 1.11) 1.05 (0.97, 1.14) 1.06 (0.97, 1.15) 0.17
Benzene 1 (Referent) 1.09 (1.00, 1.18) 1.03 (0.95, 1.12) 1.03 (0.95, 1.12) 1.06 (0.98, 1.16) 0.38
Benzidine 1 (Referent) a 0.98 (0.86, 1.12) 0.97 (0.91, 1.04) 1.06 (0.99, 1.14) 0.24
1,3-Butadiene 1 (Referent) 0.98 (0.91, 1.07) 1.06 (0.98, 1.15) 0.99 (0.91, 1.08) 1.02 (0.94, 1.11) 0.56
Carbon tetrachloride 1 (Referent) 0.98 (0.90, 1.07) 1.04 (0.96, 1.13) 1.03 (0.95, 1.12) 1.08 (1.00, 1.18) 0.03
Chloroprene 1 (Referent) a a 1.05 (0.96, 1.15) 1.07 (1.00, 1.14) 0.04
1,4-Dioxane 1 (Referent) 1.04 (0.96, 1.13) 1.05 (0.96, 1.14) 1.07 (0.99, 1.16) 1.02 (0.94, 1.11) 0.23
Ethyl carbamate 1 (Referent) a a 0.97 (0.90, 1.05) 1.07 (1.00, 1.14) 0.22
Ethylene dibromide 1 (Referent) 1.05 (0.97, 1.14) 1.07 (0.99, 1.16) 1.03 (0.95, 1.12) 1.01 (0.93, 1.10) 0.88
Ethylene dichloride 1 (Referent) 1.04 (0.95, 1.12) 0.94 (0.86, 1.02) 1.04 (0.96, 1.13) 1.05 (0.97, 1.14) 0.25
Ethylene oxide 1 (Referent) 0.93 (0.85, 1.00) 0.92 (0.85, 1.00) 0.97 (0.89, 1.05) 1.00 (0.92, 1.08) 0.70
Ethylidene dichloride 1 (Referent) 1.01 (0.93, 1.10) 1.09 (1.00, 1.18) 1.08 (0.99, 1.17) 1.02 (0.94, 1.11) 0.19
Hydrazine 1 (Referent) a 0.92 (0.86, 0.99) 0.98 (0.91, 1.06) 1.04 (0.97, 1.12) 0.36
Methylene chloride 1 (Referent) 0.97 (0.89, 1.05) 1.06 (0.98, 1.15) 1.01 (0.93, 1.10) 1.04 (0.96, 1.13) 0.21
4,4'-Methylene bis(2-chloroaniline) 1 (Referent) a a 1.02 (0.92, 1.13) 1.07 (1.01, 1.15) 0.03
Nitrobenzene 1 (Referent) a a 1.04 (0.97, 1.12) 1.03 (0.96, 1.10) 0.29
Propylene dichloride 1 (Referent) 1.00 (0.92, 1.08) 0.92 (0.85, 1.01) 1.01 (0.93, 1.09) 1.04 (0.96, 1.13) 0.20
Propylene oxide 1 (Referent) 1.05 (0.97, 1.15) 1.11 (1.02, 1.20)* 1.05 (0.97, 1.14) 1.01 (0.93, 1.10) 0.18
Styrene 1 (Referent) 1.04 (0.96, 1.13) 1.02 (0.94, 1.11) 1.05 (0.96, 1.14) 1.04 (0.96, 1.13) 0.41
2,4-Toluene diisocyanate 1 (Referent) 1.05 (0.96, 1.14) 1.04 (0.96, 1.13) 1.03 (0.95, 1.12) 1.07 (0.98, 1.16) 0.17
o-Toluidine 1 (Referent) a a 1.10 (1.01, 1.21) 1.03 (0.97, 1.10) 0.10
Vinyl chloride 1 (Referent) 1.03 (0.94, 1.12) 1.12 (1.03, 1.21)* 1.07 (0.99, 1.17) 1.06 (0.98, 1.16) 0.06
Vinylidene chloride 1 (Referent) 0.97 (0.90, 1.06) 0.98 (0.90, 1.07) 1.04 (0.96, 1.13) 1.03 (0.94, 1.11) 0.27
Summary variable 1 (Referent) 0.98 (0.90, 1.07) 0.97 (0.89, 1.05) 1.02 (0.94, 1.10) 1.05 (0.96, 1.14) 0.11
  1. Models stratified by age and adjusted for race. Quintiles based on distribution of all study participants.
  2. aQuintiles combines when a larger portion of the study participants had same concentration value.
  3. *Remains statistically significant (p < 0.05) after adjustment for multiple comparisons.