Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study

Table 2 Adjusted changes in pulse pressure (mmHg) with an IQR (15 μg/g) increase in tibia lead levels

SNP	N	Ancestral vs. Variant	Interaction term
		β (95% CI)*	β (95% CI)*	P
*Bsm1*	816	Ancestral 0.1 (-1.8, 1.9)	2.5 (0.4, 4.7)	0.02
	1626	Variant 2.6 (1.2, 4.0)
*Taq1*	827	Ancestral 0.4 (-1.4, 2.2)	2.0 (-0.1, 4.1)	0.06
	1760	Variant 2.4 (1.1, 3.8)
*Apa1*	795	Ancestral 1.5 (-0.4, 3.4)	0.3 (-1.9, 2.4)	0.81
	1787	Variant 1.8 (0.4, 3.1)
*Fok1*	974	Ancestral 2.1 (0.5, 3.7)	-0.02 (-2.0, 2.0)	0.99
	1548	Variant 2.1 (0.6, 3.6)

SNP: Single Nucleotide Polymorphism; N: Number of observations; IQR: Inter-quartile range; P: p-value of the interaction term; Ancestral: major frequency allele homozygotes; Variant: minor frequency allele homozygotes and heterozygotes.
*To compute effect estimates from longitudinal models, the time term was fixed at zero.

ISSN: 1476-069X